| Full name: TBC1 domain family member 4 | Alias Symbol: KIAA0603|AS160|DKFZp779C0666 | ||
| Type: protein-coding gene | Cytoband: 13q22.2 | ||
| Entrez ID: 9882 | HGNC ID: HGNC:19165 | Ensembl Gene: ENSG00000136111 | OMIM ID: 612465 |
| Drug and gene relationship at DGIdb | |||
TBC1D4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04919 | Thyroid hormone signaling pathway |
Expression of TBC1D4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBC1D4 | 9882 | 203386_at | 0.0878 | 0.8363 | |
| GSE20347 | TBC1D4 | 9882 | 203386_at | -0.1601 | 0.6037 | |
| GSE23400 | TBC1D4 | 9882 | 203387_s_at | 0.2185 | 0.0091 | |
| GSE26886 | TBC1D4 | 9882 | 203386_at | -0.2534 | 0.5387 | |
| GSE29001 | TBC1D4 | 9882 | 203386_at | 0.1162 | 0.7253 | |
| GSE38129 | TBC1D4 | 9882 | 203386_at | -0.2013 | 0.3568 | |
| GSE45670 | TBC1D4 | 9882 | 203386_at | -0.3496 | 0.1714 | |
| GSE53622 | TBC1D4 | 9882 | 29110 | 0.2161 | 0.0881 | |
| GSE53624 | TBC1D4 | 9882 | 29110 | -0.0242 | 0.8561 | |
| GSE63941 | TBC1D4 | 9882 | 203386_at | 0.0555 | 0.9569 | |
| GSE77861 | TBC1D4 | 9882 | 203386_at | -0.3637 | 0.2592 | |
| GSE97050 | TBC1D4 | 9882 | A_23_P88095 | 0.2513 | 0.3130 | |
| SRP007169 | TBC1D4 | 9882 | RNAseq | 1.0215 | 0.0536 | |
| SRP008496 | TBC1D4 | 9882 | RNAseq | 0.5380 | 0.1266 | |
| SRP064894 | TBC1D4 | 9882 | RNAseq | -0.0500 | 0.8567 | |
| SRP133303 | TBC1D4 | 9882 | RNAseq | -0.2252 | 0.2747 | |
| SRP159526 | TBC1D4 | 9882 | RNAseq | -0.4530 | 0.2316 | |
| SRP193095 | TBC1D4 | 9882 | RNAseq | -0.1412 | 0.3549 | |
| SRP219564 | TBC1D4 | 9882 | RNAseq | 0.1065 | 0.7663 | |
| TCGA | TBC1D4 | 9882 | RNAseq | -0.2911 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TBC1D4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBC1D4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBC1D4 | 9882 | 3 | 11 | 16 | |
| GSE20123 | TBC1D4 | 9882 | 3 | 10 | 17 | |
| GSE43470 | TBC1D4 | 9882 | 4 | 10 | 29 | |
| GSE46452 | TBC1D4 | 9882 | 0 | 32 | 27 | |
| GSE47630 | TBC1D4 | 9882 | 3 | 27 | 10 | |
| GSE54993 | TBC1D4 | 9882 | 11 | 3 | 56 | |
| GSE54994 | TBC1D4 | 9882 | 4 | 13 | 36 | |
| GSE60625 | TBC1D4 | 9882 | 0 | 3 | 8 | |
| GSE74703 | TBC1D4 | 9882 | 3 | 8 | 25 | |
| GSE74704 | TBC1D4 | 9882 | 1 | 9 | 10 | |
| TCGA | TBC1D4 | 9882 | 12 | 34 | 50 |
Total number of gains: 44; Total number of losses: 160; Total Number of normals: 284.
Somatic mutations of TBC1D4:
Generating mutation plots.
Highly correlated genes for TBC1D4:
Showing top 20/142 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBC1D4 | MBD1 | 0.809738 | 3 | 0 | 3 |
| TBC1D4 | THG1L | 0.757491 | 3 | 0 | 3 |
| TBC1D4 | CMC1 | 0.742352 | 3 | 0 | 3 |
| TBC1D4 | TMCO6 | 0.729245 | 3 | 0 | 3 |
| TBC1D4 | TRPC4AP | 0.72864 | 3 | 0 | 3 |
| TBC1D4 | LAMP1 | 0.708343 | 3 | 0 | 3 |
| TBC1D4 | SYK | 0.704588 | 3 | 0 | 3 |
| TBC1D4 | VRK3 | 0.693563 | 3 | 0 | 3 |
| TBC1D4 | ZNF627 | 0.692705 | 3 | 0 | 3 |
| TBC1D4 | SLC15A4 | 0.690778 | 3 | 0 | 3 |
| TBC1D4 | PIAS3 | 0.690732 | 3 | 0 | 3 |
| TBC1D4 | ZNF654 | 0.689885 | 3 | 0 | 3 |
| TBC1D4 | ABHD16A | 0.689199 | 3 | 0 | 3 |
| TBC1D4 | CEP41 | 0.681765 | 3 | 0 | 3 |
| TBC1D4 | KLHL36 | 0.673062 | 3 | 0 | 3 |
| TBC1D4 | MBNL3 | 0.671112 | 3 | 0 | 3 |
| TBC1D4 | ZNF184 | 0.668776 | 3 | 0 | 3 |
| TBC1D4 | NDUFAF2 | 0.668649 | 3 | 0 | 3 |
| TBC1D4 | CLP1 | 0.664699 | 4 | 0 | 3 |
| TBC1D4 | UBE4A | 0.663217 | 3 | 0 | 3 |
For details and further investigation, click here
