| Full name: taste 1 receptor member 1 | Alias Symbol: T1R1|TR1 | ||
| Type: protein-coding gene | Cytoband: 1p36.31 | ||
| Entrez ID: 80835 | HGNC ID: HGNC:14448 | Ensembl Gene: ENSG00000173662 | OMIM ID: 606225 |
| Drug and gene relationship at DGIdb | |||
TAS1R1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04742 | Taste transduction |
Expression of TAS1R1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TAS1R1 | 80835 | 1564883_a_at | -0.1006 | 0.7139 | |
| GSE26886 | TAS1R1 | 80835 | 1555417_a_at | -0.0951 | 0.3311 | |
| GSE45670 | TAS1R1 | 80835 | 1564883_a_at | 0.1154 | 0.1308 | |
| GSE53622 | TAS1R1 | 80835 | 17142 | 0.1946 | 0.0867 | |
| GSE53624 | TAS1R1 | 80835 | 17142 | 0.2470 | 0.0011 | |
| GSE63941 | TAS1R1 | 80835 | 1564883_a_at | -0.5423 | 0.0023 | |
| GSE77861 | TAS1R1 | 80835 | 1564883_a_at | -0.2001 | 0.0683 | |
| TCGA | TAS1R1 | 80835 | RNAseq | -0.1719 | 0.7469 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TAS1R1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TAS1R1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TAS1R1 | 80835 | 3 | 6 | 21 | |
| GSE20123 | TAS1R1 | 80835 | 3 | 5 | 22 | |
| GSE43470 | TAS1R1 | 80835 | 6 | 5 | 32 | |
| GSE46452 | TAS1R1 | 80835 | 7 | 1 | 51 | |
| GSE47630 | TAS1R1 | 80835 | 8 | 4 | 28 | |
| GSE54993 | TAS1R1 | 80835 | 3 | 2 | 65 | |
| GSE54994 | TAS1R1 | 80835 | 14 | 3 | 36 | |
| GSE60625 | TAS1R1 | 80835 | 0 | 0 | 11 | |
| GSE74703 | TAS1R1 | 80835 | 5 | 3 | 28 | |
| GSE74704 | TAS1R1 | 80835 | 3 | 0 | 17 | |
| TCGA | TAS1R1 | 80835 | 12 | 22 | 62 |
Total number of gains: 64; Total number of losses: 51; Total Number of normals: 373.
Somatic mutations of TAS1R1:
Generating mutation plots.
Highly correlated genes for TAS1R1:
Showing top 20/50 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TAS1R1 | SLC30A4 | 0.673745 | 3 | 0 | 3 |
| TAS1R1 | ZDHHC15 | 0.665303 | 3 | 0 | 3 |
| TAS1R1 | VASN | 0.659846 | 3 | 0 | 3 |
| TAS1R1 | CYLD | 0.652946 | 3 | 0 | 3 |
| TAS1R1 | KCNJ6 | 0.636689 | 3 | 0 | 3 |
| TAS1R1 | CARS-AS1 | 0.632012 | 3 | 0 | 3 |
| TAS1R1 | MYO1A | 0.630984 | 3 | 0 | 3 |
| TAS1R1 | ADAM12 | 0.628143 | 3 | 0 | 3 |
| TAS1R1 | CCNH | 0.625961 | 3 | 0 | 3 |
| TAS1R1 | RRAGA | 0.619902 | 3 | 0 | 3 |
| TAS1R1 | S100G | 0.619687 | 3 | 0 | 3 |
| TAS1R1 | KNCN | 0.614636 | 4 | 0 | 4 |
| TAS1R1 | CACNG8 | 0.614055 | 3 | 0 | 3 |
| TAS1R1 | NMUR2 | 0.613935 | 3 | 0 | 3 |
| TAS1R1 | METRNL | 0.609465 | 4 | 0 | 3 |
| TAS1R1 | OPTN | 0.609133 | 3 | 0 | 3 |
| TAS1R1 | SLC5A5 | 0.607534 | 3 | 0 | 3 |
| TAS1R1 | MCHR2 | 0.603466 | 3 | 0 | 3 |
| TAS1R1 | CNBD2 | 0.599706 | 3 | 0 | 3 |
| TAS1R1 | ELL2 | 0.599041 | 4 | 0 | 3 |
For details and further investigation, click here
