| Full name: ADAM metallopeptidase domain 12 | Alias Symbol: MCMPMltna|MLTN | ||
| Type: protein-coding gene | Cytoband: 10q26.2 | ||
| Entrez ID: 8038 | HGNC ID: HGNC:190 | Ensembl Gene: ENSG00000148848 | OMIM ID: 602714 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM12 | 8038 | 226777_at | 3.1082 | 0.0317 | |
| GSE20347 | ADAM12 | 8038 | 204943_at | -0.1039 | 0.2379 | |
| GSE23400 | ADAM12 | 8038 | 204943_at | -0.2432 | 0.0000 | |
| GSE26886 | ADAM12 | 8038 | 204943_at | 0.0551 | 0.7772 | |
| GSE29001 | ADAM12 | 8038 | 213790_at | 2.1333 | 0.0011 | |
| GSE38129 | ADAM12 | 8038 | 204943_at | -0.1404 | 0.0452 | |
| GSE45670 | ADAM12 | 8038 | 204943_at | 0.1025 | 0.3286 | |
| GSE53622 | ADAM12 | 8038 | 52942 | 2.5401 | 0.0000 | |
| GSE53624 | ADAM12 | 8038 | 52942 | 1.0805 | 0.0000 | |
| GSE63941 | ADAM12 | 8038 | 202952_s_at | -2.4320 | 0.0058 | |
| GSE77861 | ADAM12 | 8038 | 204943_at | -0.1712 | 0.0319 | |
| GSE97050 | ADAM12 | 8038 | A_33_P3256848 | 1.8828 | 0.1012 | |
| SRP007169 | ADAM12 | 8038 | RNAseq | 5.2177 | 0.0000 | |
| SRP008496 | ADAM12 | 8038 | RNAseq | 5.3302 | 0.0000 | |
| SRP064894 | ADAM12 | 8038 | RNAseq | 4.6733 | 0.0000 | |
| SRP133303 | ADAM12 | 8038 | RNAseq | 4.0180 | 0.0000 | |
| SRP159526 | ADAM12 | 8038 | RNAseq | 3.2137 | 0.0000 | |
| SRP193095 | ADAM12 | 8038 | RNAseq | 3.1965 | 0.0000 | |
| SRP219564 | ADAM12 | 8038 | RNAseq | 4.1917 | 0.0000 | |
| TCGA | ADAM12 | 8038 | RNAseq | 1.8587 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 1.
Survival by ADAM12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM12 | 8038 | 2 | 6 | 22 | |
| GSE20123 | ADAM12 | 8038 | 2 | 6 | 22 | |
| GSE43470 | ADAM12 | 8038 | 0 | 10 | 33 | |
| GSE46452 | ADAM12 | 8038 | 0 | 11 | 48 | |
| GSE47630 | ADAM12 | 8038 | 4 | 13 | 23 | |
| GSE54993 | ADAM12 | 8038 | 8 | 1 | 61 | |
| GSE54994 | ADAM12 | 8038 | 1 | 9 | 43 | |
| GSE60625 | ADAM12 | 8038 | 0 | 0 | 11 | |
| GSE74703 | ADAM12 | 8038 | 0 | 6 | 30 | |
| GSE74704 | ADAM12 | 8038 | 2 | 2 | 16 | |
| TCGA | ADAM12 | 8038 | 7 | 27 | 62 |
Total number of gains: 26; Total number of losses: 91; Total Number of normals: 371.
Somatic mutations of ADAM12:
Generating mutation plots.
Highly correlated genes for ADAM12:
Showing top 20/155 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM12 | KIF26B | 0.75896 | 6 | 0 | 6 |
| ADAM12 | RCN3 | 0.756683 | 6 | 0 | 6 |
| ADAM12 | CCL24 | 0.728031 | 3 | 0 | 3 |
| ADAM12 | RUNX1 | 0.719534 | 3 | 0 | 3 |
| ADAM12 | PMCH | 0.692042 | 4 | 0 | 4 |
| ADAM12 | WNT2 | 0.689853 | 4 | 0 | 4 |
| ADAM12 | C1QTNF6 | 0.670895 | 5 | 0 | 3 |
| ADAM12 | C4orf46 | 0.668711 | 4 | 0 | 4 |
| ADAM12 | KRT17 | 0.658988 | 3 | 0 | 3 |
| ADAM12 | LAMP5 | 0.654405 | 4 | 0 | 3 |
| ADAM12 | CHI3L1 | 0.648477 | 5 | 0 | 4 |
| ADAM12 | SDS | 0.647722 | 5 | 0 | 4 |
| ADAM12 | SPOCD1 | 0.645535 | 4 | 0 | 4 |
| ADAM12 | NAV1 | 0.64477 | 4 | 0 | 4 |
| ADAM12 | MME | 0.642967 | 5 | 0 | 4 |
| ADAM12 | DPPA2 | 0.641757 | 3 | 0 | 3 |
| ADAM12 | IL4I1 | 0.63777 | 4 | 0 | 3 |
| ADAM12 | TCL1B | 0.637715 | 3 | 0 | 3 |
| ADAM12 | HAGHL | 0.634594 | 6 | 0 | 4 |
| ADAM12 | HSCB | 0.633398 | 3 | 0 | 3 |
For details and further investigation, click here
