| Full name: TBC1 domain containing kinase | Alias Symbol: MGC16169|HSPC302 | ||
| Type: protein-coding gene | Cytoband: 4q24 | ||
| Entrez ID: 93627 | HGNC ID: HGNC:28261 | Ensembl Gene: ENSG00000145348 | OMIM ID: 616899 |
| Drug and gene relationship at DGIdb | |||
Expression of TBCK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBCK | 93627 | 226126_at | -0.2653 | 0.5155 | |
| GSE26886 | TBCK | 93627 | 226126_at | 0.4446 | 0.0512 | |
| GSE45670 | TBCK | 93627 | 226126_at | -0.1106 | 0.6193 | |
| GSE53622 | TBCK | 93627 | 99431 | -0.1637 | 0.0265 | |
| GSE53624 | TBCK | 93627 | 99431 | -0.3317 | 0.0000 | |
| GSE63941 | TBCK | 93627 | 226126_at | -0.4015 | 0.4722 | |
| GSE77861 | TBCK | 93627 | 226126_at | -0.6463 | 0.1277 | |
| GSE97050 | TBCK | 93627 | A_23_P133075 | 0.0379 | 0.9301 | |
| SRP007169 | TBCK | 93627 | RNAseq | -0.6420 | 0.0557 | |
| SRP008496 | TBCK | 93627 | RNAseq | -0.6298 | 0.0050 | |
| SRP064894 | TBCK | 93627 | RNAseq | -0.3371 | 0.0696 | |
| SRP133303 | TBCK | 93627 | RNAseq | 0.1052 | 0.5612 | |
| SRP159526 | TBCK | 93627 | RNAseq | -0.4175 | 0.0570 | |
| SRP193095 | TBCK | 93627 | RNAseq | -0.2914 | 0.0093 | |
| SRP219564 | TBCK | 93627 | RNAseq | -0.1009 | 0.6033 | |
| TCGA | TBCK | 93627 | RNAseq | -0.0364 | 0.5283 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TBCK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBCK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBCK | 93627 | 0 | 12 | 18 | |
| GSE20123 | TBCK | 93627 | 0 | 12 | 18 | |
| GSE43470 | TBCK | 93627 | 0 | 13 | 30 | |
| GSE46452 | TBCK | 93627 | 1 | 36 | 22 | |
| GSE47630 | TBCK | 93627 | 0 | 20 | 20 | |
| GSE54993 | TBCK | 93627 | 9 | 0 | 61 | |
| GSE54994 | TBCK | 93627 | 1 | 10 | 42 | |
| GSE60625 | TBCK | 93627 | 0 | 3 | 8 | |
| GSE74703 | TBCK | 93627 | 0 | 11 | 25 | |
| GSE74704 | TBCK | 93627 | 0 | 6 | 14 | |
| TCGA | TBCK | 93627 | 8 | 38 | 50 |
Total number of gains: 19; Total number of losses: 161; Total Number of normals: 308.
Somatic mutations of TBCK:
Generating mutation plots.
Highly correlated genes for TBCK:
Showing top 20/169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBCK | PGM1 | 0.807571 | 3 | 0 | 3 |
| TBCK | ZNF319 | 0.773094 | 3 | 0 | 3 |
| TBCK | RPS24 | 0.768544 | 3 | 0 | 3 |
| TBCK | IQGAP1 | 0.753917 | 3 | 0 | 3 |
| TBCK | GLCE | 0.748327 | 3 | 0 | 3 |
| TBCK | SLC35E3 | 0.741274 | 3 | 0 | 3 |
| TBCK | RBM33 | 0.739063 | 3 | 0 | 3 |
| TBCK | REEP3 | 0.737439 | 3 | 0 | 3 |
| TBCK | SCAF11 | 0.733751 | 3 | 0 | 3 |
| TBCK | WDR47 | 0.732445 | 3 | 0 | 3 |
| TBCK | GATAD1 | 0.730824 | 3 | 0 | 3 |
| TBCK | NSMCE4A | 0.728984 | 3 | 0 | 3 |
| TBCK | MCC | 0.720629 | 3 | 0 | 3 |
| TBCK | GPHN | 0.718049 | 3 | 0 | 3 |
| TBCK | HSPB11 | 0.711825 | 3 | 0 | 3 |
| TBCK | UBE4B | 0.709255 | 3 | 0 | 3 |
| TBCK | AKAP10 | 0.707456 | 3 | 0 | 3 |
| TBCK | SNX15 | 0.706727 | 3 | 0 | 3 |
| TBCK | RPS23 | 0.705451 | 3 | 0 | 3 |
| TBCK | ZSWIM5 | 0.704797 | 3 | 0 | 3 |
For details and further investigation, click here
