| Full name: NSE4 homolog A, SMC5-SMC6 complex component | Alias Symbol: FLJ20003|bA500G22.3|NSE4A | ||
| Type: protein-coding gene | Cytoband: 10q26.13 | ||
| Entrez ID: 54780 | HGNC ID: HGNC:25935 | Ensembl Gene: ENSG00000107672 | OMIM ID: 612987 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NSMCE4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NSMCE4A | 54780 | 211376_s_at | -0.5587 | 0.2103 | |
| GSE20347 | NSMCE4A | 54780 | 219067_s_at | 0.1735 | 0.2176 | |
| GSE23400 | NSMCE4A | 54780 | 219067_s_at | 0.0845 | 0.3412 | |
| GSE26886 | NSMCE4A | 54780 | 219067_s_at | 1.0022 | 0.0004 | |
| GSE29001 | NSMCE4A | 54780 | 219067_s_at | 0.0221 | 0.9512 | |
| GSE38129 | NSMCE4A | 54780 | 219067_s_at | 0.0953 | 0.4536 | |
| GSE45670 | NSMCE4A | 54780 | 219067_s_at | -0.2695 | 0.0532 | |
| GSE53622 | NSMCE4A | 54780 | 162989 | -0.0978 | 0.2367 | |
| GSE53624 | NSMCE4A | 54780 | 162989 | -0.1132 | 0.1562 | |
| GSE63941 | NSMCE4A | 54780 | 211376_s_at | 1.1816 | 0.0016 | |
| GSE77861 | NSMCE4A | 54780 | 211376_s_at | -0.0400 | 0.9331 | |
| GSE97050 | NSMCE4A | 54780 | A_24_P189458 | 0.1065 | 0.7525 | |
| SRP007169 | NSMCE4A | 54780 | RNAseq | -0.3600 | 0.3557 | |
| SRP008496 | NSMCE4A | 54780 | RNAseq | 0.0196 | 0.9468 | |
| SRP064894 | NSMCE4A | 54780 | RNAseq | -0.4080 | 0.0053 | |
| SRP133303 | NSMCE4A | 54780 | RNAseq | -0.1718 | 0.2809 | |
| SRP159526 | NSMCE4A | 54780 | RNAseq | 0.0164 | 0.9583 | |
| SRP193095 | NSMCE4A | 54780 | RNAseq | -0.1911 | 0.1283 | |
| SRP219564 | NSMCE4A | 54780 | RNAseq | -0.1345 | 0.5898 | |
| TCGA | NSMCE4A | 54780 | RNAseq | -0.1240 | 0.0195 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NSMCE4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NSMCE4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NSMCE4A | 54780 | 2 | 7 | 21 | |
| GSE20123 | NSMCE4A | 54780 | 2 | 7 | 21 | |
| GSE43470 | NSMCE4A | 54780 | 0 | 9 | 34 | |
| GSE46452 | NSMCE4A | 54780 | 0 | 11 | 48 | |
| GSE47630 | NSMCE4A | 54780 | 2 | 14 | 24 | |
| GSE54993 | NSMCE4A | 54780 | 8 | 1 | 61 | |
| GSE54994 | NSMCE4A | 54780 | 1 | 9 | 43 | |
| GSE60625 | NSMCE4A | 54780 | 0 | 0 | 11 | |
| GSE74703 | NSMCE4A | 54780 | 0 | 6 | 30 | |
| GSE74704 | NSMCE4A | 54780 | 1 | 2 | 17 | |
| TCGA | NSMCE4A | 54780 | 4 | 28 | 64 |
Total number of gains: 20; Total number of losses: 94; Total Number of normals: 374.
Somatic mutations of NSMCE4A:
Generating mutation plots.
Highly correlated genes for NSMCE4A:
Showing top 20/557 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NSMCE4A | KAT5 | 0.806056 | 3 | 0 | 3 |
| NSMCE4A | WHAMM | 0.798115 | 3 | 0 | 3 |
| NSMCE4A | CRLS1 | 0.797054 | 3 | 0 | 3 |
| NSMCE4A | RTN4IP1 | 0.790255 | 3 | 0 | 3 |
| NSMCE4A | SYNE2 | 0.785962 | 3 | 0 | 3 |
| NSMCE4A | CDC26 | 0.782839 | 3 | 0 | 3 |
| NSMCE4A | PRDX2 | 0.781062 | 3 | 0 | 3 |
| NSMCE4A | RBM7 | 0.76729 | 4 | 0 | 4 |
| NSMCE4A | BLOC1S1 | 0.766909 | 3 | 0 | 3 |
| NSMCE4A | TRAP1 | 0.762609 | 3 | 0 | 3 |
| NSMCE4A | MAP3K13 | 0.753985 | 3 | 0 | 3 |
| NSMCE4A | TRUB1 | 0.752893 | 3 | 0 | 3 |
| NSMCE4A | MIF4GD | 0.751412 | 4 | 0 | 4 |
| NSMCE4A | NXF1 | 0.746164 | 3 | 0 | 3 |
| NSMCE4A | TMEM185A | 0.74171 | 3 | 0 | 3 |
| NSMCE4A | SSRP1 | 0.739917 | 4 | 0 | 3 |
| NSMCE4A | INTS12 | 0.730652 | 5 | 0 | 5 |
| NSMCE4A | TBCK | 0.728984 | 3 | 0 | 3 |
| NSMCE4A | LITAF | 0.72698 | 3 | 0 | 3 |
| NSMCE4A | HIBADH | 0.725587 | 3 | 0 | 3 |
For details and further investigation, click here
