| Full name: MCC regulator of WNT signaling pathway | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q22.2 | ||
| Entrez ID: 4163 | HGNC ID: HGNC:6935 | Ensembl Gene: ENSG00000171444 | OMIM ID: 159350 |
| Drug and gene relationship at DGIdb | |||
Expression of MCC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCC | 4163 | 226225_at | -0.6571 | 0.6999 | |
| GSE20347 | MCC | 4163 | 206132_at | -0.3474 | 0.0155 | |
| GSE23400 | MCC | 4163 | 206132_at | -0.0796 | 0.1948 | |
| GSE26886 | MCC | 4163 | 226225_at | 0.4376 | 0.2049 | |
| GSE29001 | MCC | 4163 | 206132_at | -0.4125 | 0.0380 | |
| GSE38129 | MCC | 4163 | 206132_at | -0.1361 | 0.4422 | |
| GSE45670 | MCC | 4163 | 226225_at | 0.3513 | 0.0551 | |
| GSE53622 | MCC | 4163 | 44994 | 0.1386 | 0.1694 | |
| GSE53624 | MCC | 4163 | 22225 | 0.0487 | 0.6252 | |
| GSE63941 | MCC | 4163 | 226225_at | -1.1971 | 0.2555 | |
| GSE77861 | MCC | 4163 | 206132_at | -0.0145 | 0.9637 | |
| GSE97050 | MCC | 4163 | A_33_P3288246 | 0.1357 | 0.6428 | |
| SRP007169 | MCC | 4163 | RNAseq | 0.4362 | 0.2401 | |
| SRP008496 | MCC | 4163 | RNAseq | 0.4688 | 0.0133 | |
| SRP064894 | MCC | 4163 | RNAseq | -0.0629 | 0.8181 | |
| SRP133303 | MCC | 4163 | RNAseq | 0.6314 | 0.0420 | |
| SRP159526 | MCC | 4163 | RNAseq | -0.4667 | 0.3306 | |
| SRP193095 | MCC | 4163 | RNAseq | 0.2545 | 0.2047 | |
| SRP219564 | MCC | 4163 | RNAseq | 0.1378 | 0.8171 | |
| TCGA | MCC | 4163 | RNAseq | 0.2317 | 0.0017 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MCC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCC | 4163 | 1 | 13 | 16 | |
| GSE20123 | MCC | 4163 | 1 | 13 | 16 | |
| GSE43470 | MCC | 4163 | 3 | 9 | 31 | |
| GSE46452 | MCC | 4163 | 0 | 28 | 31 | |
| GSE47630 | MCC | 4163 | 0 | 21 | 19 | |
| GSE54993 | MCC | 4163 | 9 | 1 | 60 | |
| GSE54994 | MCC | 4163 | 1 | 17 | 35 | |
| GSE60625 | MCC | 4163 | 0 | 0 | 11 | |
| GSE74703 | MCC | 4163 | 2 | 7 | 27 | |
| GSE74704 | MCC | 4163 | 1 | 7 | 12 | |
| TCGA | MCC | 4163 | 2 | 42 | 52 |
Total number of gains: 20; Total number of losses: 158; Total Number of normals: 310.
Somatic mutations of MCC:
Generating mutation plots.
Highly correlated genes for MCC:
Showing top 20/279 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCC | USP40 | 0.765303 | 3 | 0 | 3 |
| MCC | HHLA1 | 0.743554 | 3 | 0 | 3 |
| MCC | TBCK | 0.720629 | 3 | 0 | 3 |
| MCC | ALDH1A3 | 0.710865 | 3 | 0 | 3 |
| MCC | CAV3 | 0.705544 | 3 | 0 | 3 |
| MCC | ADAM11 | 0.699474 | 3 | 0 | 3 |
| MCC | ARF6 | 0.689335 | 4 | 0 | 3 |
| MCC | F2RL1 | 0.68151 | 4 | 0 | 3 |
| MCC | LTA | 0.672945 | 3 | 0 | 3 |
| MCC | CYB5R1 | 0.669488 | 4 | 0 | 3 |
| MCC | SCAPER | 0.65997 | 3 | 0 | 3 |
| MCC | GFM1 | 0.656098 | 3 | 0 | 3 |
| MCC | ZBTB33 | 0.649797 | 3 | 0 | 3 |
| MCC | ZCCHC10 | 0.649526 | 3 | 0 | 3 |
| MCC | GPR137 | 0.646911 | 3 | 0 | 3 |
| MCC | MGAT4B | 0.646168 | 3 | 0 | 3 |
| MCC | RPS6KB1 | 0.641834 | 3 | 0 | 3 |
| MCC | BMP2 | 0.638819 | 4 | 0 | 3 |
| MCC | UGCG | 0.636899 | 4 | 0 | 3 |
| MCC | HOMER2 | 0.635112 | 6 | 0 | 5 |
For details and further investigation, click here
