| Full name: IQ motif containing GTPase activating protein 1 | Alias Symbol: p195|KIAA0051|SAR1|HUMORFA01 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 8826 | HGNC ID: HGNC:6110 | Ensembl Gene: ENSG00000140575 | OMIM ID: 603379 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
IQGAP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04520 | Adherens junction | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05205 | Proteoglycans in cancer |
Expression of IQGAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IQGAP1 | 8826 | 200791_s_at | -0.6624 | 0.2275 | |
| GSE20347 | IQGAP1 | 8826 | 200791_s_at | -0.5392 | 0.0394 | |
| GSE23400 | IQGAP1 | 8826 | 200791_s_at | -0.2312 | 0.0043 | |
| GSE26886 | IQGAP1 | 8826 | 200791_s_at | -0.2752 | 0.2116 | |
| GSE29001 | IQGAP1 | 8826 | 200791_s_at | -0.4855 | 0.0855 | |
| GSE38129 | IQGAP1 | 8826 | 200791_s_at | -0.3983 | 0.0190 | |
| GSE45670 | IQGAP1 | 8826 | 200791_s_at | -0.2836 | 0.0316 | |
| GSE53622 | IQGAP1 | 8826 | 12478 | -0.3922 | 0.0000 | |
| GSE53624 | IQGAP1 | 8826 | 12478 | -0.4087 | 0.0000 | |
| GSE63941 | IQGAP1 | 8826 | 200791_s_at | 0.1063 | 0.7852 | |
| GSE77861 | IQGAP1 | 8826 | 200791_s_at | -0.2421 | 0.3145 | |
| GSE97050 | IQGAP1 | 8826 | A_33_P3417745 | -0.1402 | 0.7038 | |
| SRP007169 | IQGAP1 | 8826 | RNAseq | -0.1181 | 0.6909 | |
| SRP008496 | IQGAP1 | 8826 | RNAseq | -0.1204 | 0.4741 | |
| SRP064894 | IQGAP1 | 8826 | RNAseq | -0.4393 | 0.0449 | |
| SRP133303 | IQGAP1 | 8826 | RNAseq | -0.1183 | 0.5271 | |
| SRP159526 | IQGAP1 | 8826 | RNAseq | -0.5878 | 0.0684 | |
| SRP193095 | IQGAP1 | 8826 | RNAseq | -0.3428 | 0.0060 | |
| SRP219564 | IQGAP1 | 8826 | RNAseq | -0.2066 | 0.6027 | |
| TCGA | IQGAP1 | 8826 | RNAseq | 0.0582 | 0.1949 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IQGAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IQGAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IQGAP1 | 8826 | 8 | 3 | 19 | |
| GSE20123 | IQGAP1 | 8826 | 8 | 3 | 19 | |
| GSE43470 | IQGAP1 | 8826 | 5 | 5 | 33 | |
| GSE46452 | IQGAP1 | 8826 | 3 | 7 | 49 | |
| GSE47630 | IQGAP1 | 8826 | 8 | 11 | 21 | |
| GSE54993 | IQGAP1 | 8826 | 4 | 6 | 60 | |
| GSE54994 | IQGAP1 | 8826 | 7 | 6 | 40 | |
| GSE60625 | IQGAP1 | 8826 | 4 | 0 | 7 | |
| GSE74703 | IQGAP1 | 8826 | 4 | 4 | 28 | |
| GSE74704 | IQGAP1 | 8826 | 4 | 2 | 14 | |
| TCGA | IQGAP1 | 8826 | 18 | 12 | 66 |
Total number of gains: 73; Total number of losses: 59; Total Number of normals: 356.
Somatic mutations of IQGAP1:
Generating mutation plots.
Highly correlated genes for IQGAP1:
Showing top 20/577 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IQGAP1 | NUDCD3 | 0.806499 | 3 | 0 | 3 |
| IQGAP1 | TMEM106B | 0.763292 | 3 | 0 | 3 |
| IQGAP1 | HOXA3 | 0.754078 | 3 | 0 | 3 |
| IQGAP1 | TBCK | 0.753917 | 3 | 0 | 3 |
| IQGAP1 | PPP3CC | 0.747544 | 4 | 0 | 4 |
| IQGAP1 | SNAP23 | 0.734314 | 4 | 0 | 4 |
| IQGAP1 | TBC1D20 | 0.727769 | 3 | 0 | 3 |
| IQGAP1 | THYN1 | 0.724013 | 3 | 0 | 3 |
| IQGAP1 | RBAK | 0.72252 | 3 | 0 | 3 |
| IQGAP1 | COMMD10 | 0.717318 | 3 | 0 | 3 |
| IQGAP1 | SNX14 | 0.711231 | 3 | 0 | 3 |
| IQGAP1 | CCNY | 0.709047 | 3 | 0 | 3 |
| IQGAP1 | DRAM2 | 0.706799 | 3 | 0 | 3 |
| IQGAP1 | ALAS1 | 0.704296 | 4 | 0 | 3 |
| IQGAP1 | EIF3I | 0.698467 | 3 | 0 | 3 |
| IQGAP1 | TMEM161B | 0.696283 | 3 | 0 | 3 |
| IQGAP1 | APC | 0.695224 | 4 | 0 | 3 |
| IQGAP1 | PLCD3 | 0.694481 | 4 | 0 | 3 |
| IQGAP1 | KCTD9 | 0.692099 | 6 | 0 | 6 |
| IQGAP1 | KCMF1 | 0.691572 | 3 | 0 | 3 |
For details and further investigation, click here
