| Full name: TATA-box binding protein | Alias Symbol: TFIID | ||
| Type: protein-coding gene | Cytoband: 6q27 | ||
| Entrez ID: 6908 | HGNC ID: HGNC:11588 | Ensembl Gene: ENSG00000112592 | OMIM ID: 600075 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TBP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05166 | HTLV-I infection |
Expression of TBP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBP | 6908 | 203135_at | 0.2310 | 0.3845 | |
| GSE20347 | TBP | 6908 | 203135_at | 0.2996 | 0.0218 | |
| GSE23400 | TBP | 6908 | 203135_at | 0.3072 | 0.0000 | |
| GSE26886 | TBP | 6908 | 203135_at | -0.1025 | 0.7028 | |
| GSE29001 | TBP | 6908 | 203135_at | 0.1692 | 0.5103 | |
| GSE38129 | TBP | 6908 | 203135_at | 0.3585 | 0.0013 | |
| GSE45670 | TBP | 6908 | 203135_at | 0.2595 | 0.0329 | |
| GSE53622 | TBP | 6908 | 27853 | 0.3597 | 0.0000 | |
| GSE53624 | TBP | 6908 | 27853 | 0.3460 | 0.0000 | |
| GSE63941 | TBP | 6908 | 203135_at | 0.5554 | 0.1049 | |
| GSE77861 | TBP | 6908 | 203135_at | 0.4907 | 0.0066 | |
| GSE97050 | TBP | 6908 | A_23_P19313 | 0.1505 | 0.4952 | |
| SRP007169 | TBP | 6908 | RNAseq | 0.6470 | 0.1638 | |
| SRP008496 | TBP | 6908 | RNAseq | 0.0975 | 0.7746 | |
| SRP064894 | TBP | 6908 | RNAseq | 0.1324 | 0.2837 | |
| SRP133303 | TBP | 6908 | RNAseq | 0.3190 | 0.0476 | |
| SRP159526 | TBP | 6908 | RNAseq | -0.0919 | 0.6423 | |
| SRP193095 | TBP | 6908 | RNAseq | 0.1299 | 0.1319 | |
| SRP219564 | TBP | 6908 | RNAseq | 0.0576 | 0.7913 | |
| TCGA | TBP | 6908 | RNAseq | 0.0788 | 0.1955 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TBP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBP | 6908 | 4 | 6 | 20 | |
| GSE20123 | TBP | 6908 | 4 | 6 | 20 | |
| GSE43470 | TBP | 6908 | 2 | 0 | 41 | |
| GSE46452 | TBP | 6908 | 3 | 10 | 46 | |
| GSE47630 | TBP | 6908 | 7 | 7 | 26 | |
| GSE54993 | TBP | 6908 | 4 | 3 | 63 | |
| GSE54994 | TBP | 6908 | 9 | 9 | 35 | |
| GSE60625 | TBP | 6908 | 1 | 1 | 9 | |
| GSE74703 | TBP | 6908 | 2 | 0 | 34 | |
| GSE74704 | TBP | 6908 | 2 | 3 | 15 | |
| TCGA | TBP | 6908 | 14 | 20 | 62 |
Total number of gains: 52; Total number of losses: 65; Total Number of normals: 371.
Somatic mutations of TBP:
Generating mutation plots.
Highly correlated genes for TBP:
Showing top 20/1003 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBP | LCAT | 0.843586 | 3 | 0 | 3 |
| TBP | ANAPC4 | 0.789334 | 3 | 0 | 3 |
| TBP | KRTCAP2 | 0.786992 | 3 | 0 | 3 |
| TBP | STRADA | 0.784871 | 3 | 0 | 3 |
| TBP | NUFIP2 | 0.773754 | 3 | 0 | 3 |
| TBP | ST6GAL1 | 0.754309 | 3 | 0 | 3 |
| TBP | SDHAF2 | 0.747392 | 3 | 0 | 3 |
| TBP | GNA13 | 0.744377 | 3 | 0 | 3 |
| TBP | TMEM18 | 0.739005 | 3 | 0 | 3 |
| TBP | PPP6R2 | 0.736496 | 3 | 0 | 3 |
| TBP | WDR75 | 0.735177 | 4 | 0 | 3 |
| TBP | DPP9 | 0.731945 | 3 | 0 | 3 |
| TBP | GPR107 | 0.722413 | 3 | 0 | 3 |
| TBP | MSTO1 | 0.717589 | 4 | 0 | 4 |
| TBP | CCDC127 | 0.711661 | 4 | 0 | 3 |
| TBP | C2orf69 | 0.708185 | 4 | 0 | 3 |
| TBP | AKAP17A | 0.708067 | 3 | 0 | 3 |
| TBP | ZSCAN21 | 0.704399 | 3 | 0 | 3 |
| TBP | PTER | 0.699079 | 3 | 0 | 3 |
| TBP | RAPGEF4 | 0.696541 | 4 | 0 | 3 |
For details and further investigation, click here
