| Full name: Rap guanine nucleotide exchange factor 4 | Alias Symbol: cAMP-GEFII|CGEF2 | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 11069 | HGNC ID: HGNC:16626 | Ensembl Gene: ENSG00000091428 | OMIM ID: 606058 |
| Drug and gene relationship at DGIdb | |||
RAPGEF4 involved pathways:
Expression of RAPGEF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAPGEF4 | 11069 | 205651_x_at | 1.0276 | 0.1162 | |
| GSE20347 | RAPGEF4 | 11069 | 205651_x_at | 0.0250 | 0.8537 | |
| GSE23400 | RAPGEF4 | 11069 | 205651_x_at | 0.0726 | 0.0006 | |
| GSE26886 | RAPGEF4 | 11069 | 205651_x_at | 0.6453 | 0.0126 | |
| GSE29001 | RAPGEF4 | 11069 | 205651_x_at | 0.2490 | 0.5535 | |
| GSE38129 | RAPGEF4 | 11069 | 205651_x_at | 0.1231 | 0.5459 | |
| GSE45670 | RAPGEF4 | 11069 | 205651_x_at | -0.3101 | 0.3673 | |
| GSE53622 | RAPGEF4 | 11069 | 68055 | 0.2112 | 0.0637 | |
| GSE53624 | RAPGEF4 | 11069 | 68055 | 0.4205 | 0.0003 | |
| GSE63941 | RAPGEF4 | 11069 | 205651_x_at | 0.3827 | 0.5677 | |
| GSE77861 | RAPGEF4 | 11069 | 205651_x_at | 0.2468 | 0.2735 | |
| GSE97050 | RAPGEF4 | 11069 | A_23_P17192 | 0.0366 | 0.9088 | |
| SRP007169 | RAPGEF4 | 11069 | RNAseq | 2.4856 | 0.0023 | |
| SRP064894 | RAPGEF4 | 11069 | RNAseq | 0.2506 | 0.3809 | |
| SRP133303 | RAPGEF4 | 11069 | RNAseq | 0.0670 | 0.7663 | |
| SRP159526 | RAPGEF4 | 11069 | RNAseq | -0.3406 | 0.2926 | |
| SRP193095 | RAPGEF4 | 11069 | RNAseq | 0.4830 | 0.0049 | |
| SRP219564 | RAPGEF4 | 11069 | RNAseq | -0.4603 | 0.1893 | |
| TCGA | RAPGEF4 | 11069 | RNAseq | -0.5335 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RAPGEF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAPGEF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAPGEF4 | 11069 | 10 | 0 | 20 | |
| GSE20123 | RAPGEF4 | 11069 | 10 | 0 | 20 | |
| GSE43470 | RAPGEF4 | 11069 | 8 | 1 | 34 | |
| GSE46452 | RAPGEF4 | 11069 | 1 | 4 | 54 | |
| GSE47630 | RAPGEF4 | 11069 | 5 | 3 | 32 | |
| GSE54993 | RAPGEF4 | 11069 | 0 | 5 | 65 | |
| GSE54994 | RAPGEF4 | 11069 | 12 | 3 | 38 | |
| GSE60625 | RAPGEF4 | 11069 | 0 | 3 | 8 | |
| GSE74703 | RAPGEF4 | 11069 | 6 | 1 | 29 | |
| GSE74704 | RAPGEF4 | 11069 | 6 | 0 | 14 | |
| TCGA | RAPGEF4 | 11069 | 29 | 5 | 62 |
Total number of gains: 87; Total number of losses: 25; Total Number of normals: 376.
Somatic mutations of RAPGEF4:
Generating mutation plots.
Highly correlated genes for RAPGEF4:
Showing top 20/596 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAPGEF4 | RLIM | 0.767197 | 3 | 0 | 3 |
| RAPGEF4 | PCYT1A | 0.757359 | 3 | 0 | 3 |
| RAPGEF4 | OSGEP | 0.748712 | 3 | 0 | 3 |
| RAPGEF4 | IGSF8 | 0.747408 | 3 | 0 | 3 |
| RAPGEF4 | USP40 | 0.733904 | 3 | 0 | 3 |
| RAPGEF4 | C9orf64 | 0.723272 | 3 | 0 | 3 |
| RAPGEF4 | IL6R | 0.721474 | 4 | 0 | 3 |
| RAPGEF4 | ITGB4 | 0.72011 | 3 | 0 | 3 |
| RAPGEF4 | MRPS28 | 0.715847 | 3 | 0 | 3 |
| RAPGEF4 | YWHAG | 0.71373 | 3 | 0 | 3 |
| RAPGEF4 | LRRC39 | 0.712239 | 3 | 0 | 3 |
| RAPGEF4 | ALKBH6 | 0.706871 | 3 | 0 | 3 |
| RAPGEF4 | SF3A2 | 0.703807 | 3 | 0 | 3 |
| RAPGEF4 | SAAL1 | 0.702179 | 3 | 0 | 3 |
| RAPGEF4 | ERVW-1 | 0.70114 | 3 | 0 | 3 |
| RAPGEF4 | TYW5 | 0.698828 | 3 | 0 | 3 |
| RAPGEF4 | TGFB1 | 0.697789 | 3 | 0 | 3 |
| RAPGEF4 | LARP1 | 0.697104 | 3 | 0 | 3 |
| RAPGEF4 | TBP | 0.696541 | 4 | 0 | 3 |
| RAPGEF4 | CAMKK1 | 0.696102 | 4 | 0 | 4 |
For details and further investigation, click here
