| Full name: R-spondin 2 | Alias Symbol: MGC35555 | ||
| Type: protein-coding gene | Cytoband: 8q23.1 | ||
| Entrez ID: 340419 | HGNC ID: HGNC:28583 | Ensembl Gene: ENSG00000147655 | OMIM ID: 610575 |
| Drug and gene relationship at DGIdb | |||
Expression of RSPO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | RSPO2 | 340419 | 117253 | -2.6815 | 0.0000 | |
| GSE53624 | RSPO2 | 340419 | 117253 | -2.8271 | 0.0000 | |
| GSE63941 | RSPO2 | 340419 | 1554012_at | -3.4469 | 0.0000 | |
| SRP064894 | RSPO2 | 340419 | RNAseq | -1.3615 | 0.0128 | |
| SRP133303 | RSPO2 | 340419 | RNAseq | -2.5728 | 0.0000 | |
| SRP159526 | RSPO2 | 340419 | RNAseq | -1.6818 | 0.0364 | |
| SRP219564 | RSPO2 | 340419 | RNAseq | -1.1470 | 0.3091 | |
| TCGA | RSPO2 | 340419 | RNAseq | -1.9202 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by RSPO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RSPO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RSPO2 | 340419 | 16 | 0 | 14 | |
| GSE20123 | RSPO2 | 340419 | 17 | 0 | 13 | |
| GSE43470 | RSPO2 | 340419 | 22 | 0 | 21 | |
| GSE46452 | RSPO2 | 340419 | 25 | 0 | 34 | |
| GSE47630 | RSPO2 | 340419 | 24 | 0 | 16 | |
| GSE54993 | RSPO2 | 340419 | 0 | 20 | 50 | |
| GSE54994 | RSPO2 | 340419 | 37 | 1 | 15 | |
| GSE60625 | RSPO2 | 340419 | 0 | 4 | 7 | |
| GSE74703 | RSPO2 | 340419 | 19 | 0 | 17 | |
| GSE74704 | RSPO2 | 340419 | 11 | 0 | 9 | |
| TCGA | RSPO2 | 340419 | 59 | 1 | 36 |
Total number of gains: 230; Total number of losses: 26; Total Number of normals: 232.
Somatic mutations of RSPO2:
Generating mutation plots.
Highly correlated genes for RSPO2:
Showing top 20/259 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RSPO2 | TMEM100 | 0.835213 | 3 | 0 | 3 |
| RSPO2 | ASPA | 0.827865 | 3 | 0 | 3 |
| RSPO2 | FENDRR | 0.80528 | 3 | 0 | 3 |
| RSPO2 | TCF21 | 0.803209 | 3 | 0 | 3 |
| RSPO2 | SHISA3 | 0.803192 | 3 | 0 | 3 |
| RSPO2 | RCAN2 | 0.79908 | 3 | 0 | 3 |
| RSPO2 | NME5 | 0.792434 | 3 | 0 | 3 |
| RSPO2 | LINC01082 | 0.791275 | 3 | 0 | 3 |
| RSPO2 | ABCA8 | 0.789836 | 3 | 0 | 3 |
| RSPO2 | ZNF536 | 0.789827 | 3 | 0 | 3 |
| RSPO2 | JAM2 | 0.787904 | 3 | 0 | 3 |
| RSPO2 | PRUNE2 | 0.782961 | 3 | 0 | 3 |
| RSPO2 | ADH1B | 0.782518 | 3 | 0 | 3 |
| RSPO2 | PLCXD3 | 0.780365 | 3 | 0 | 3 |
| RSPO2 | NEGR1 | 0.780089 | 3 | 0 | 3 |
| RSPO2 | ARHGAP20 | 0.778706 | 3 | 0 | 3 |
| RSPO2 | BNC2 | 0.777007 | 3 | 0 | 3 |
| RSPO2 | FYCO1 | 0.774152 | 3 | 0 | 3 |
| RSPO2 | F10 | 0.773674 | 3 | 0 | 3 |
| RSPO2 | LRRK2 | 0.769815 | 3 | 0 | 3 |
For details and further investigation, click here
