| Full name: transcription factor AP-4 | Alias Symbol: AP-4|bHLHc41 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 7023 | HGNC ID: HGNC:11745 | Ensembl Gene: ENSG00000090447 | OMIM ID: 600743 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TFAP4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of TFAP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TFAP4 | 7023 | 205688_at | 0.2114 | 0.2195 | |
| GSE20347 | TFAP4 | 7023 | 205688_at | 0.1883 | 0.0105 | |
| GSE23400 | TFAP4 | 7023 | 205688_at | 0.1144 | 0.0089 | |
| GSE26886 | TFAP4 | 7023 | 205688_at | 0.4780 | 0.0005 | |
| GSE29001 | TFAP4 | 7023 | 205688_at | -0.0755 | 0.7190 | |
| GSE38129 | TFAP4 | 7023 | 205688_at | 0.0725 | 0.5383 | |
| GSE45670 | TFAP4 | 7023 | 205688_at | 0.1936 | 0.0362 | |
| GSE53622 | TFAP4 | 7023 | 121161 | 0.8380 | 0.0000 | |
| GSE53624 | TFAP4 | 7023 | 121161 | 1.1930 | 0.0000 | |
| GSE63941 | TFAP4 | 7023 | 205688_at | 0.6144 | 0.0051 | |
| GSE77861 | TFAP4 | 7023 | 205688_at | 0.1733 | 0.1943 | |
| GSE97050 | TFAP4 | 7023 | A_23_P141092 | 0.7031 | 0.1189 | |
| SRP007169 | TFAP4 | 7023 | RNAseq | 1.9792 | 0.0035 | |
| SRP064894 | TFAP4 | 7023 | RNAseq | 0.7367 | 0.0028 | |
| SRP133303 | TFAP4 | 7023 | RNAseq | 0.6928 | 0.0004 | |
| SRP159526 | TFAP4 | 7023 | RNAseq | 1.1569 | 0.0000 | |
| SRP193095 | TFAP4 | 7023 | RNAseq | 0.6853 | 0.0000 | |
| SRP219564 | TFAP4 | 7023 | RNAseq | 1.4789 | 0.0139 | |
| TCGA | TFAP4 | 7023 | RNAseq | 0.5290 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by TFAP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TFAP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TFAP4 | 7023 | 5 | 5 | 20 | |
| GSE20123 | TFAP4 | 7023 | 5 | 4 | 21 | |
| GSE43470 | TFAP4 | 7023 | 5 | 6 | 32 | |
| GSE46452 | TFAP4 | 7023 | 38 | 1 | 20 | |
| GSE47630 | TFAP4 | 7023 | 13 | 6 | 21 | |
| GSE54993 | TFAP4 | 7023 | 3 | 5 | 62 | |
| GSE54994 | TFAP4 | 7023 | 5 | 9 | 39 | |
| GSE60625 | TFAP4 | 7023 | 4 | 0 | 7 | |
| GSE74703 | TFAP4 | 7023 | 5 | 4 | 27 | |
| GSE74704 | TFAP4 | 7023 | 3 | 2 | 15 | |
| TCGA | TFAP4 | 7023 | 19 | 13 | 64 |
Total number of gains: 105; Total number of losses: 55; Total Number of normals: 328.
Somatic mutations of TFAP4:
Generating mutation plots.
Highly correlated genes for TFAP4:
Showing top 20/1266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TFAP4 | ZNF358 | 0.781156 | 3 | 0 | 3 |
| TFAP4 | FRMD8 | 0.761843 | 3 | 0 | 3 |
| TFAP4 | ZNF707 | 0.757463 | 3 | 0 | 3 |
| TFAP4 | UCK2 | 0.756855 | 3 | 0 | 3 |
| TFAP4 | SARDH | 0.744774 | 3 | 0 | 3 |
| TFAP4 | PTCD1 | 0.736426 | 3 | 0 | 3 |
| TFAP4 | DKC1 | 0.732779 | 3 | 0 | 3 |
| TFAP4 | C11orf68 | 0.728843 | 3 | 0 | 3 |
| TFAP4 | HHLA3 | 0.724642 | 3 | 0 | 3 |
| TFAP4 | PMS2 | 0.722783 | 3 | 0 | 3 |
| TFAP4 | FAM167B | 0.718436 | 3 | 0 | 3 |
| TFAP4 | FAM89B | 0.71428 | 4 | 0 | 4 |
| TFAP4 | PTPMT1 | 0.712688 | 3 | 0 | 3 |
| TFAP4 | SAMD4B | 0.711297 | 4 | 0 | 4 |
| TFAP4 | SCNM1 | 0.709958 | 3 | 0 | 3 |
| TFAP4 | DICER1 | 0.708311 | 4 | 0 | 3 |
| TFAP4 | LIN9 | 0.704891 | 5 | 0 | 5 |
| TFAP4 | ADAM15 | 0.704615 | 4 | 0 | 4 |
| TFAP4 | CSF2RA | 0.702119 | 3 | 0 | 3 |
| TFAP4 | MMS22L | 0.701848 | 3 | 0 | 3 |
For details and further investigation, click here
