| Full name: HERV-H LTR-associating 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p31.1 | ||
| Entrez ID: 11147 | HGNC ID: HGNC:4906 | Ensembl Gene: ENSG00000197568 | OMIM ID: 604372 |
| Drug and gene relationship at DGIdb | |||
Expression of HHLA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HHLA3 | 11147 | 234665_x_at | 0.0259 | 0.9673 | |
| GSE20347 | HHLA3 | 11147 | 220387_s_at | -0.2027 | 0.3522 | |
| GSE23400 | HHLA3 | 11147 | 220387_s_at | -0.0075 | 0.9080 | |
| GSE26886 | HHLA3 | 11147 | 234665_x_at | -0.0066 | 0.9649 | |
| GSE29001 | HHLA3 | 11147 | 220387_s_at | -0.1287 | 0.5871 | |
| GSE38129 | HHLA3 | 11147 | 220387_s_at | -0.1841 | 0.3839 | |
| GSE45670 | HHLA3 | 11147 | 234665_x_at | -0.0217 | 0.8996 | |
| GSE53622 | HHLA3 | 11147 | 101487 | -0.0248 | 0.7585 | |
| GSE53624 | HHLA3 | 11147 | 104163 | 0.0023 | 0.9802 | |
| GSE63941 | HHLA3 | 11147 | 234665_x_at | 1.9314 | 0.0007 | |
| GSE77861 | HHLA3 | 11147 | 234665_x_at | -0.0971 | 0.5916 | |
| GSE97050 | HHLA3 | 11147 | A_24_P182281 | 0.1528 | 0.4598 | |
| SRP007169 | HHLA3 | 11147 | RNAseq | -0.7967 | 0.1302 | |
| SRP064894 | HHLA3 | 11147 | RNAseq | 0.4132 | 0.2306 | |
| SRP133303 | HHLA3 | 11147 | RNAseq | -0.1249 | 0.6073 | |
| SRP159526 | HHLA3 | 11147 | RNAseq | -0.4232 | 0.3154 | |
| SRP193095 | HHLA3 | 11147 | RNAseq | -0.2838 | 0.0514 | |
| SRP219564 | HHLA3 | 11147 | RNAseq | 0.0327 | 0.9436 | |
| TCGA | HHLA3 | 11147 | RNAseq | 0.1467 | 0.2236 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HHLA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HHLA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HHLA3 | 11147 | 2 | 6 | 22 | |
| GSE20123 | HHLA3 | 11147 | 2 | 5 | 23 | |
| GSE43470 | HHLA3 | 11147 | 4 | 4 | 35 | |
| GSE46452 | HHLA3 | 11147 | 0 | 1 | 58 | |
| GSE47630 | HHLA3 | 11147 | 7 | 6 | 27 | |
| GSE54993 | HHLA3 | 11147 | 0 | 0 | 70 | |
| GSE54994 | HHLA3 | 11147 | 6 | 4 | 43 | |
| GSE60625 | HHLA3 | 11147 | 0 | 0 | 11 | |
| GSE74703 | HHLA3 | 11147 | 3 | 3 | 30 | |
| GSE74704 | HHLA3 | 11147 | 1 | 2 | 17 | |
| TCGA | HHLA3 | 11147 | 8 | 22 | 66 |
Total number of gains: 33; Total number of losses: 53; Total Number of normals: 402.
Somatic mutations of HHLA3:
Generating mutation plots.
Highly correlated genes for HHLA3:
Showing top 20/166 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HHLA3 | TGFB2 | 0.786701 | 3 | 0 | 3 |
| HHLA3 | SPTAN1 | 0.780262 | 4 | 0 | 4 |
| HHLA3 | CD22 | 0.736252 | 3 | 0 | 3 |
| HHLA3 | TFAP4 | 0.724642 | 3 | 0 | 3 |
| HHLA3 | NGF | 0.715295 | 3 | 0 | 3 |
| HHLA3 | PRTN3 | 0.710565 | 3 | 0 | 3 |
| HHLA3 | RNF43 | 0.694797 | 3 | 0 | 3 |
| HHLA3 | TINAGL1 | 0.688996 | 4 | 0 | 4 |
| HHLA3 | SAMD4B | 0.684117 | 3 | 0 | 3 |
| HHLA3 | ZNF747 | 0.678875 | 3 | 0 | 3 |
| HHLA3 | PROX1 | 0.678445 | 3 | 0 | 3 |
| HHLA3 | ELOVL7 | 0.677316 | 3 | 0 | 3 |
| HHLA3 | USP5 | 0.675716 | 3 | 0 | 3 |
| HHLA3 | KALRN | 0.674611 | 3 | 0 | 3 |
| HHLA3 | CEP85 | 0.671414 | 3 | 0 | 3 |
| HHLA3 | LZTS1 | 0.670598 | 3 | 0 | 3 |
| HHLA3 | DPY30 | 0.663729 | 4 | 0 | 3 |
| HHLA3 | CDH7 | 0.663489 | 3 | 0 | 3 |
| HHLA3 | RTN4R | 0.66096 | 3 | 0 | 3 |
| HHLA3 | PRKCSH | 0.660112 | 3 | 0 | 3 |
For details and further investigation, click here
