Full name: dyskerin pseudouridine synthase 1	Alias Symbol: XAP101|dyskerin|NAP57|NOLA4|Cbf5
Type: protein-coding gene	Cytoband: Xq28
Entrez ID: 1736	HGNC ID: HGNC:2890	Ensembl Gene: ENSG00000130826	OMIM ID: 300126
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of DKC1:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE53622	DKC1	1736	34518	0.7982	0.0000	Show
GSE53624	DKC1	1736	34518	0.9675	0.0000	Show
GSE97050	DKC1	1736	A_23_P137143	0.5867	0.1930	Show
SRP007169	DKC1	1736	RNAseq	1.5982	0.0007	Show
SRP008496	DKC1	1736	RNAseq	1.6635	0.0000	Show
SRP064894	DKC1	1736	RNAseq	0.7335	0.0012	Show
SRP133303	DKC1	1736	RNAseq	1.1522	0.0000	Show
SRP159526	DKC1	1736	RNAseq	0.8501	0.0023	Show
SRP193095	DKC1	1736	RNAseq	0.5563	0.0003	Show
SRP219564	DKC1	1736	RNAseq	0.9151	0.0578	Show
TCGA	DKC1	1736	RNAseq	0.3678	0.0000	Show

Upregulated datasets: 3; Downregulated datasets: 0.  Download Data

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Survival by DKC1 expression:

 

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Copy number change of DKC1:

 

No record found for this gene.

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Somatic mutations of DKC1:

 

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Highly correlated genes for DKC1:

 

Showing top 20/693 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
DKC1	BLM	0.823618	3	0	3
DKC1	BIRC5	0.821495	3	0	3
DKC1	TTK	0.813786	3	0	3
DKC1	DDX39A	0.811564	3	0	3
DKC1	NOP2	0.806874	3	0	3
DKC1	GINS1	0.805936	3	0	3
DKC1	UBE2C	0.803963	3	0	3
DKC1	RUVBL1	0.80242	3	0	3
DKC1	CENPN	0.801192	3	0	3
DKC1	NLN	0.798765	3	0	3
DKC1	DCAF13	0.792192	3	0	3
DKC1	HJURP	0.791885	3	0	3
DKC1	CEP55	0.789929	3	0	3
DKC1	SKA1	0.789494	3	0	3
DKC1	CCNF	0.788333	3	0	3
DKC1	CDT1	0.786305	3	0	3
DKC1	TOP1MT	0.784535	3	0	3
DKC1	NEK2	0.784285	3	0	3
DKC1	CCNA2	0.783404	3	0	3
DKC1	CEP85	0.782971	3	0	3

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