| Full name: tissue factor pathway inhibitor | Alias Symbol: EPI|TFI|TFPI1 | ||
| Type: protein-coding gene | Cytoband: 2q32.1 | ||
| Entrez ID: 7035 | HGNC ID: HGNC:11760 | Ensembl Gene: ENSG00000003436 | OMIM ID: 152310 |
| Drug and gene relationship at DGIdb | |||
TFPI involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of TFPI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TFPI | 7035 | 213258_at | -1.4038 | 0.1021 | |
| GSE20347 | TFPI | 7035 | 213258_at | -0.4199 | 0.3658 | |
| GSE23400 | TFPI | 7035 | 213258_at | -0.4704 | 0.0044 | |
| GSE26886 | TFPI | 7035 | 213258_at | -0.1348 | 0.8329 | |
| GSE29001 | TFPI | 7035 | 210664_s_at | -0.3690 | 0.5058 | |
| GSE38129 | TFPI | 7035 | 213258_at | -0.8740 | 0.0396 | |
| GSE45670 | TFPI | 7035 | 213258_at | -1.9827 | 0.0000 | |
| GSE53622 | TFPI | 7035 | 134621 | -1.2286 | 0.0000 | |
| GSE53624 | TFPI | 7035 | 134621 | -0.8472 | 0.0000 | |
| GSE63941 | TFPI | 7035 | 213258_at | -5.8339 | 0.0101 | |
| GSE77861 | TFPI | 7035 | 210664_s_at | 0.2886 | 0.6532 | |
| GSE97050 | TFPI | 7035 | A_33_P3258274 | -0.2022 | 0.4132 | |
| SRP007169 | TFPI | 7035 | RNAseq | 2.1806 | 0.0004 | |
| SRP008496 | TFPI | 7035 | RNAseq | 1.7184 | 0.0001 | |
| SRP064894 | TFPI | 7035 | RNAseq | 0.0179 | 0.9611 | |
| SRP133303 | TFPI | 7035 | RNAseq | -0.8053 | 0.0004 | |
| SRP159526 | TFPI | 7035 | RNAseq | -0.0938 | 0.8773 | |
| SRP193095 | TFPI | 7035 | RNAseq | 0.1277 | 0.6749 | |
| SRP219564 | TFPI | 7035 | RNAseq | -0.2154 | 0.6636 | |
| TCGA | TFPI | 7035 | RNAseq | -0.3041 | 0.0119 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by TFPI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TFPI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TFPI | 7035 | 7 | 1 | 22 | |
| GSE20123 | TFPI | 7035 | 7 | 1 | 22 | |
| GSE43470 | TFPI | 7035 | 3 | 1 | 39 | |
| GSE46452 | TFPI | 7035 | 1 | 4 | 54 | |
| GSE47630 | TFPI | 7035 | 4 | 5 | 31 | |
| GSE54993 | TFPI | 7035 | 0 | 5 | 65 | |
| GSE54994 | TFPI | 7035 | 12 | 6 | 35 | |
| GSE60625 | TFPI | 7035 | 0 | 3 | 8 | |
| GSE74703 | TFPI | 7035 | 2 | 1 | 33 | |
| GSE74704 | TFPI | 7035 | 3 | 1 | 16 | |
| TCGA | TFPI | 7035 | 24 | 6 | 66 |
Total number of gains: 63; Total number of losses: 34; Total Number of normals: 391.
Somatic mutations of TFPI:
Generating mutation plots.
Highly correlated genes for TFPI:
Showing top 20/924 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TFPI | GIMAP5 | 0.80839 | 3 | 0 | 3 |
| TFPI | LINC01279 | 0.799648 | 4 | 0 | 4 |
| TFPI | BHLHE22 | 0.777178 | 5 | 0 | 5 |
| TFPI | ZNF583 | 0.761178 | 3 | 0 | 3 |
| TFPI | TNFSF12 | 0.758107 | 3 | 0 | 3 |
| TFPI | GIMAP1 | 0.757732 | 5 | 0 | 5 |
| TFPI | CNRIP1 | 0.750858 | 7 | 0 | 6 |
| TFPI | GNG11 | 0.749401 | 11 | 0 | 10 |
| TFPI | MMRN1 | 0.747934 | 8 | 0 | 7 |
| TFPI | CLEC3B | 0.746965 | 3 | 0 | 3 |
| TFPI | PTPRB | 0.746111 | 8 | 0 | 7 |
| TFPI | SMPD1 | 0.744792 | 4 | 0 | 4 |
| TFPI | TPSD1 | 0.740933 | 4 | 0 | 4 |
| TFPI | CCNDBP1 | 0.736086 | 3 | 0 | 3 |
| TFPI | C11orf96 | 0.730122 | 4 | 0 | 4 |
| TFPI | BMX | 0.728997 | 6 | 0 | 6 |
| TFPI | C9orf72 | 0.725574 | 4 | 0 | 3 |
| TFPI | LRRN4CL | 0.724645 | 7 | 0 | 6 |
| TFPI | MAML2 | 0.724381 | 3 | 0 | 3 |
| TFPI | APOLD1 | 0.721764 | 8 | 0 | 8 |
For details and further investigation, click here
