TGIF1

 

Full name: TGFB induced factor homeobox 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 18p11.31
Entrez ID: 7050 HGNC ID: HGNC:11776 Ensembl Gene: ENSG00000177426 OMIM ID: 602630
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 29/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TGIF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TGIF1 7050 203313_s_at 0.7448 0.3123
GSE20347 TGIF1 7050 203313_s_at 0.9965 0.0000
GSE23400 TGIF1 7050 203313_s_at 1.0362 0.0000
GSE26886 TGIF1 7050 203313_s_at 1.0391 0.0000
GSE29001 TGIF1 7050 203313_s_at 0.5268 0.1137
GSE38129 TGIF1 7050 203313_s_at 1.1469 0.0000
GSE45670 TGIF1 7050 203313_s_at 0.4656 0.0837
GSE53622 TGIF1 7050 111602 0.1462 0.2442
GSE53624 TGIF1 7050 111602 0.5000 0.0000
GSE63941 TGIF1 7050 203313_s_at 0.8357 0.2677
GSE77861 TGIF1 7050 203313_s_at 1.6602 0.0213
GSE97050 TGIF1 7050 A_33_P3311717 -0.0626 0.8276
SRP007169 TGIF1 7050 RNAseq 0.7032 0.0636
SRP008496 TGIF1 7050 RNAseq 0.4169 0.1335
SRP064894 TGIF1 7050 RNAseq 1.2287 0.0000
SRP133303 TGIF1 7050 RNAseq 1.0439 0.0001
SRP159526 TGIF1 7050 RNAseq 1.4856 0.0001
SRP193095 TGIF1 7050 RNAseq 1.1708 0.0000
SRP219564 TGIF1 7050 RNAseq 0.6231 0.0240
TCGA TGIF1 7050 RNAseq 0.2030 0.0005

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by TGIF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TGIF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TGIF1 7050 8 2 20
GSE20123 TGIF1 7050 8 2 20
GSE43470 TGIF1 7050 4 5 34
GSE46452 TGIF1 7050 3 20 36
GSE47630 TGIF1 7050 8 17 15
GSE54993 TGIF1 7050 5 5 60
GSE54994 TGIF1 7050 11 8 34
GSE60625 TGIF1 7050 0 4 7
GSE74703 TGIF1 7050 3 3 30
GSE74704 TGIF1 7050 6 1 13
TCGA TGIF1 7050 36 17 43

Total number of gains: 92; Total number of losses: 84; Total Number of normals: 312.  

 

Somatic mutations of TGIF1:

 

Generating mutation plots.

 

Highly correlated genes for TGIF1:

 

Showing top 20/598 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TGIF1IL31RA0.737978404
TGIF1ZRANB30.689802303
TGIF1DLGAP1-AS10.689797403
TGIF1POU6F2-AS20.68807403
TGIF1DCBLD20.686683303
TGIF1BLACAT10.682394303
TGIF1FMNL20.678129404
TGIF1AMMECR1L0.677517303
TGIF1ANLN0.677422303
TGIF1NSUN60.674121303
TGIF1GALNT180.673199404
TGIF1C8orf580.671071303
TGIF1MORC20.670198707
TGIF1SLC16A10.666979606
TGIF1DLGAP1-AS20.665538504
TGIF1NDC800.663311807
TGIF1ITGA30.661443505
TGIF1SHC10.657952706
TGIF1ILKAP0.657433303
TGIF1CDCA20.655361303

For details and further investigation, click here