NDC80

 

Full name: NDC80 kinetochore complex component Alias Symbol: HEC|HEC1|hsNDC80|TID3
Type: protein-coding gene Cytoband: 18p11.32
Entrez ID: 10403 HGNC ID: HGNC:16909 Ensembl Gene: ENSG00000080986 OMIM ID: 607272
Drug and gene relationship at DGIdb

 

Expression of NDC80:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NDC80 10403 204162_at 1.0765 0.2496
GSE20347 NDC80 10403 204162_at 1.7711 0.0000
GSE23400 NDC80 10403 204162_at 0.9963 0.0000
GSE26886 NDC80 10403 204162_at 0.8273 0.0600
GSE29001 NDC80 10403 204162_at 1.8578 0.0001
GSE38129 NDC80 10403 204162_at 1.9825 0.0000
GSE45670 NDC80 10403 204162_at 1.5878 0.0000
GSE53622 NDC80 10403 26504 1.5212 0.0000
GSE53624 NDC80 10403 26504 1.8419 0.0000
GSE63941 NDC80 10403 204162_at 3.0789 0.0001
GSE77861 NDC80 10403 204162_at 1.0065 0.0343
GSE97050 NDC80 10403 A_23_P50108 1.3239 0.0912
SRP007169 NDC80 10403 RNAseq 2.1372 0.0000
SRP008496 NDC80 10403 RNAseq 1.8467 0.0000
SRP064894 NDC80 10403 RNAseq 2.2178 0.0000
SRP133303 NDC80 10403 RNAseq 1.7241 0.0000
SRP159526 NDC80 10403 RNAseq 1.5920 0.0004
SRP193095 NDC80 10403 RNAseq 0.9973 0.0000
SRP219564 NDC80 10403 RNAseq 0.9590 0.0518
TCGA NDC80 10403 RNAseq 1.3352 0.0000

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by NDC80 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NDC80:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NDC80 10403 7 3 20
GSE20123 NDC80 10403 7 3 20
GSE43470 NDC80 10403 2 5 36
GSE46452 NDC80 10403 3 20 36
GSE47630 NDC80 10403 7 18 15
GSE54993 NDC80 10403 6 3 61
GSE54994 NDC80 10403 12 8 33
GSE60625 NDC80 10403 0 4 7
GSE74703 NDC80 10403 2 3 31
GSE74704 NDC80 10403 5 2 13
TCGA NDC80 10403 36 17 43

Total number of gains: 87; Total number of losses: 86; Total Number of normals: 315.  

 

Somatic mutations of NDC80:

 

Generating mutation plots.

 

Highly correlated genes for NDC80:

 

Showing top 20/1889 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NDC80NUF20.823617909
NDC80TYMS0.81874713013
NDC80BUB10.81444111011
NDC80KIF20A0.8137513013
NDC80ASPM0.81124413013
NDC80CENPF0.81091913012
NDC80TTK0.81018813012
NDC80NEK20.80965413012
NDC80KIF140.80857913012
NDC80MMS22L0.80798303
NDC80ANLN0.807914908
NDC80CEP550.80472913013
NDC80TOP2A0.80172613013
NDC80CDKN30.8004813013
NDC80CDK10.7989712012
NDC80CDC200.7954212011
NDC80KIF2C0.79065113012
NDC80GINS10.78622712012
NDC80HJURP0.78470413011
NDC80AURKA0.78262913013

For details and further investigation, click here