| Full name: integrin subunit alpha 3 | Alias Symbol: CD49c|VLA3a|VCA-2|GAP-B3 | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 3675 | HGNC ID: HGNC:6139 | Ensembl Gene: ENSG00000005884 | OMIM ID: 605025 |
| Drug and gene relationship at DGIdb | |||
ITGA3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of ITGA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGA3 | 3675 | 201474_s_at | 1.0508 | 0.0659 | |
| GSE20347 | ITGA3 | 3675 | 201474_s_at | 0.6390 | 0.0042 | |
| GSE23400 | ITGA3 | 3675 | 201474_s_at | 0.8489 | 0.0000 | |
| GSE26886 | ITGA3 | 3675 | 201474_s_at | 2.3008 | 0.0000 | |
| GSE29001 | ITGA3 | 3675 | 201474_s_at | 0.6700 | 0.0126 | |
| GSE38129 | ITGA3 | 3675 | 201474_s_at | 0.7346 | 0.0002 | |
| GSE45670 | ITGA3 | 3675 | 201474_s_at | 1.2890 | 0.0005 | |
| GSE53622 | ITGA3 | 3675 | 51512 | 1.3888 | 0.0000 | |
| GSE53624 | ITGA3 | 3675 | 51512 | 1.4619 | 0.0000 | |
| GSE63941 | ITGA3 | 3675 | 201474_s_at | 1.9802 | 0.0008 | |
| GSE77861 | ITGA3 | 3675 | 201474_s_at | 1.0148 | 0.0125 | |
| GSE97050 | ITGA3 | 3675 | A_23_P55251 | 1.4597 | 0.0556 | |
| SRP007169 | ITGA3 | 3675 | RNAseq | 1.8477 | 0.0000 | |
| SRP008496 | ITGA3 | 3675 | RNAseq | 1.4961 | 0.0000 | |
| SRP064894 | ITGA3 | 3675 | RNAseq | 1.9220 | 0.0000 | |
| SRP133303 | ITGA3 | 3675 | RNAseq | 2.0975 | 0.0000 | |
| SRP159526 | ITGA3 | 3675 | RNAseq | 0.6884 | 0.0799 | |
| SRP193095 | ITGA3 | 3675 | RNAseq | 1.5797 | 0.0000 | |
| TCGA | ITGA3 | 3675 | RNAseq | 0.2439 | 0.0111 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by ITGA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGA3 | 3675 | 5 | 2 | 23 | |
| GSE20123 | ITGA3 | 3675 | 5 | 2 | 23 | |
| GSE43470 | ITGA3 | 3675 | 3 | 2 | 38 | |
| GSE46452 | ITGA3 | 3675 | 32 | 0 | 27 | |
| GSE47630 | ITGA3 | 3675 | 9 | 0 | 31 | |
| GSE54993 | ITGA3 | 3675 | 2 | 4 | 64 | |
| GSE54994 | ITGA3 | 3675 | 9 | 6 | 38 | |
| GSE60625 | ITGA3 | 3675 | 4 | 0 | 7 | |
| GSE74703 | ITGA3 | 3675 | 3 | 2 | 31 | |
| GSE74704 | ITGA3 | 3675 | 4 | 1 | 15 | |
| TCGA | ITGA3 | 3675 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of ITGA3:
Generating mutation plots.
Highly correlated genes for ITGA3:
Showing top 20/1724 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGA3 | A4GALT | 0.832884 | 3 | 0 | 3 |
| ITGA3 | ITGB4 | 0.824169 | 13 | 0 | 13 |
| ITGA3 | PSPC1 | 0.80677 | 3 | 0 | 3 |
| ITGA3 | LARS2 | 0.78384 | 3 | 0 | 3 |
| ITGA3 | RILPL2 | 0.779591 | 3 | 0 | 3 |
| ITGA3 | XPR1 | 0.774765 | 7 | 0 | 7 |
| ITGA3 | WDR81 | 0.773479 | 3 | 0 | 3 |
| ITGA3 | ABCB6 | 0.762852 | 3 | 0 | 3 |
| ITGA3 | PXN | 0.762763 | 12 | 0 | 12 |
| ITGA3 | ARPC1B | 0.758976 | 11 | 0 | 11 |
| ITGA3 | C9orf16 | 0.756536 | 3 | 0 | 3 |
| ITGA3 | FBLIM1 | 0.755746 | 8 | 0 | 7 |
| ITGA3 | PLAU | 0.75569 | 12 | 0 | 12 |
| ITGA3 | GPR153 | 0.755192 | 8 | 0 | 7 |
| ITGA3 | CCM2 | 0.754996 | 8 | 0 | 8 |
| ITGA3 | TESK1 | 0.754966 | 3 | 0 | 3 |
| ITGA3 | SPON2 | 0.751155 | 3 | 0 | 3 |
| ITGA3 | WDR54 | 0.749318 | 7 | 0 | 7 |
| ITGA3 | SDR39U1 | 0.747981 | 3 | 0 | 3 |
| ITGA3 | AGRN | 0.747962 | 13 | 0 | 13 |
For details and further investigation, click here
