| Full name: tripartite motif containing 8 | Alias Symbol: GERP | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 81603 | HGNC ID: HGNC:15579 | Ensembl Gene: ENSG00000171206 | OMIM ID: 606125 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TRIM8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRIM8 | 81603 | 223132_s_at | 0.1259 | 0.8271 | |
| GSE20347 | TRIM8 | 81603 | 221012_s_at | -0.4696 | 0.0015 | |
| GSE23400 | TRIM8 | 81603 | 221012_s_at | -0.2283 | 0.0099 | |
| GSE26886 | TRIM8 | 81603 | 221012_s_at | 0.7357 | 0.0195 | |
| GSE29001 | TRIM8 | 81603 | 221012_s_at | -0.3950 | 0.1107 | |
| GSE38129 | TRIM8 | 81603 | 221012_s_at | -0.4890 | 0.0011 | |
| GSE45670 | TRIM8 | 81603 | 221012_s_at | -0.7037 | 0.0001 | |
| GSE53622 | TRIM8 | 81603 | 58172 | 0.0152 | 0.8463 | |
| GSE53624 | TRIM8 | 81603 | 58172 | -0.0823 | 0.2622 | |
| GSE63941 | TRIM8 | 81603 | 221012_s_at | -1.7168 | 0.0012 | |
| GSE77861 | TRIM8 | 81603 | 223132_s_at | -0.3310 | 0.1903 | |
| GSE97050 | TRIM8 | 81603 | A_23_P46844 | 0.0857 | 0.7240 | |
| SRP007169 | TRIM8 | 81603 | RNAseq | -1.0462 | 0.0069 | |
| SRP008496 | TRIM8 | 81603 | RNAseq | -1.1088 | 0.0000 | |
| SRP064894 | TRIM8 | 81603 | RNAseq | -0.2030 | 0.2079 | |
| SRP133303 | TRIM8 | 81603 | RNAseq | -0.3240 | 0.0106 | |
| SRP159526 | TRIM8 | 81603 | RNAseq | -0.4015 | 0.1545 | |
| SRP193095 | TRIM8 | 81603 | RNAseq | -0.0081 | 0.9590 | |
| SRP219564 | TRIM8 | 81603 | RNAseq | -0.2043 | 0.5526 | |
| TCGA | TRIM8 | 81603 | RNAseq | -0.2028 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TRIM8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRIM8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRIM8 | 81603 | 2 | 9 | 19 | |
| GSE20123 | TRIM8 | 81603 | 2 | 8 | 20 | |
| GSE43470 | TRIM8 | 81603 | 0 | 8 | 35 | |
| GSE46452 | TRIM8 | 81603 | 0 | 11 | 48 | |
| GSE47630 | TRIM8 | 81603 | 2 | 14 | 24 | |
| GSE54993 | TRIM8 | 81603 | 8 | 0 | 62 | |
| GSE54994 | TRIM8 | 81603 | 1 | 11 | 41 | |
| GSE60625 | TRIM8 | 81603 | 0 | 0 | 11 | |
| GSE74703 | TRIM8 | 81603 | 0 | 5 | 31 | |
| GSE74704 | TRIM8 | 81603 | 1 | 4 | 15 | |
| TCGA | TRIM8 | 81603 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 99; Total Number of normals: 368.
Somatic mutations of TRIM8:
Generating mutation plots.
Highly correlated genes for TRIM8:
Showing top 20/712 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRIM8 | ABHD16A | 0.825743 | 3 | 0 | 3 |
| TRIM8 | NIPAL3 | 0.825397 | 4 | 0 | 4 |
| TRIM8 | ARHGAP31 | 0.825391 | 3 | 0 | 3 |
| TRIM8 | SLC35B3 | 0.820531 | 3 | 0 | 3 |
| TRIM8 | ZNF766 | 0.809645 | 3 | 0 | 3 |
| TRIM8 | ARID2 | 0.798398 | 3 | 0 | 3 |
| TRIM8 | SAMD9L | 0.787854 | 3 | 0 | 3 |
| TRIM8 | EI24 | 0.781386 | 3 | 0 | 3 |
| TRIM8 | ZMAT3 | 0.768475 | 3 | 0 | 3 |
| TRIM8 | CNOT2 | 0.766798 | 3 | 0 | 3 |
| TRIM8 | ARID1B | 0.761915 | 4 | 0 | 3 |
| TRIM8 | MRVI1 | 0.757664 | 3 | 0 | 3 |
| TRIM8 | ERGIC1 | 0.757558 | 3 | 0 | 3 |
| TRIM8 | RFX1 | 0.755825 | 3 | 0 | 3 |
| TRIM8 | CCDC102B | 0.742357 | 3 | 0 | 3 |
| TRIM8 | FIBIN | 0.740508 | 3 | 0 | 3 |
| TRIM8 | ARHGAP35 | 0.738229 | 3 | 0 | 3 |
| TRIM8 | RGS7BP | 0.73744 | 3 | 0 | 3 |
| TRIM8 | ZBTB2 | 0.726752 | 3 | 0 | 3 |
| TRIM8 | IP6K1 | 0.717927 | 5 | 0 | 5 |
For details and further investigation, click here
