| Full name: AF4/FMR2 family member 1 | Alias Symbol: AF-4|AF4 | ||
| Type: protein-coding gene | Cytoband: 4q21.3-q22.1 | ||
| Entrez ID: 4299 | HGNC ID: HGNC:7135 | Ensembl Gene: ENSG00000172493 | OMIM ID: 159557 |
| Drug and gene relationship at DGIdb | |||
Expression of AFF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AFF1 | 4299 | 201924_at | -0.3494 | 0.4262 | |
| GSE20347 | AFF1 | 4299 | 201924_at | -0.7920 | 0.0000 | |
| GSE23400 | AFF1 | 4299 | 201924_at | -0.3099 | 0.0002 | |
| GSE26886 | AFF1 | 4299 | 201924_at | 0.3499 | 0.1101 | |
| GSE29001 | AFF1 | 4299 | 201924_at | -0.6632 | 0.0133 | |
| GSE38129 | AFF1 | 4299 | 201924_at | -0.8336 | 0.0000 | |
| GSE45670 | AFF1 | 4299 | 201924_at | -0.7111 | 0.0000 | |
| GSE53622 | AFF1 | 4299 | 173646 | -0.6077 | 0.0000 | |
| GSE53624 | AFF1 | 4299 | 173646 | -0.5077 | 0.0000 | |
| GSE63941 | AFF1 | 4299 | 201924_at | -1.4595 | 0.0440 | |
| GSE77861 | AFF1 | 4299 | 201924_at | -0.2830 | 0.4084 | |
| GSE97050 | AFF1 | 4299 | A_33_P3242373 | -0.3902 | 0.1888 | |
| SRP007169 | AFF1 | 4299 | RNAseq | -0.2736 | 0.4725 | |
| SRP008496 | AFF1 | 4299 | RNAseq | -0.1539 | 0.5150 | |
| SRP064894 | AFF1 | 4299 | RNAseq | -0.5655 | 0.0334 | |
| SRP133303 | AFF1 | 4299 | RNAseq | -0.4295 | 0.0360 | |
| SRP159526 | AFF1 | 4299 | RNAseq | -1.2419 | 0.0003 | |
| SRP193095 | AFF1 | 4299 | RNAseq | -0.4545 | 0.0000 | |
| SRP219564 | AFF1 | 4299 | RNAseq | -0.5686 | 0.0457 | |
| TCGA | AFF1 | 4299 | RNAseq | -0.2524 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by AFF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AFF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AFF1 | 4299 | 3 | 12 | 15 | |
| GSE20123 | AFF1 | 4299 | 3 | 12 | 15 | |
| GSE43470 | AFF1 | 4299 | 0 | 13 | 30 | |
| GSE46452 | AFF1 | 4299 | 2 | 35 | 22 | |
| GSE47630 | AFF1 | 4299 | 0 | 20 | 20 | |
| GSE54993 | AFF1 | 4299 | 8 | 0 | 62 | |
| GSE54994 | AFF1 | 4299 | 1 | 9 | 43 | |
| GSE60625 | AFF1 | 4299 | 0 | 0 | 11 | |
| GSE74703 | AFF1 | 4299 | 0 | 11 | 25 | |
| GSE74704 | AFF1 | 4299 | 2 | 7 | 11 | |
| TCGA | AFF1 | 4299 | 12 | 36 | 48 |
Total number of gains: 31; Total number of losses: 155; Total Number of normals: 302.
Somatic mutations of AFF1:
Generating mutation plots.
Highly correlated genes for AFF1:
Showing top 20/1058 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AFF1 | EPHA3 | 0.764891 | 3 | 0 | 3 |
| AFF1 | MACROD2 | 0.764005 | 3 | 0 | 3 |
| AFF1 | GGA3 | 0.738574 | 3 | 0 | 3 |
| AFF1 | SNRK | 0.73008 | 7 | 0 | 7 |
| AFF1 | CRBN | 0.729576 | 7 | 0 | 6 |
| AFF1 | RBM20 | 0.725814 | 4 | 0 | 4 |
| AFF1 | DENND4C | 0.724458 | 6 | 0 | 6 |
| AFF1 | NFIA | 0.721927 | 6 | 0 | 5 |
| AFF1 | GHR | 0.720036 | 3 | 0 | 3 |
| AFF1 | SCAF8 | 0.713299 | 3 | 0 | 3 |
| AFF1 | AK3 | 0.712899 | 4 | 0 | 3 |
| AFF1 | MICA | 0.711876 | 3 | 0 | 3 |
| AFF1 | PRELP | 0.704819 | 4 | 0 | 4 |
| AFF1 | TSNARE1 | 0.703995 | 3 | 0 | 3 |
| AFF1 | KIAA1109 | 0.701365 | 11 | 0 | 10 |
| AFF1 | NMT2 | 0.696443 | 3 | 0 | 3 |
| AFF1 | THBS4 | 0.692031 | 3 | 0 | 3 |
| AFF1 | ZMAT1 | 0.690862 | 5 | 0 | 4 |
| AFF1 | BRD8 | 0.690366 | 3 | 0 | 3 |
| AFF1 | OMD | 0.686785 | 4 | 0 | 4 |
For details and further investigation, click here
