| Full name: HD domain containing 3 | Alias Symbol: MGC45386 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 374659 | HGNC ID: HGNC:30522 | Ensembl Gene: ENSG00000184508 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of HDDC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HDDC3 | 374659 | 227008_at | -0.0111 | 0.9851 | |
| GSE26886 | HDDC3 | 374659 | 227008_at | 0.3548 | 0.0638 | |
| GSE45670 | HDDC3 | 374659 | 227008_at | 0.2637 | 0.1452 | |
| GSE53622 | HDDC3 | 374659 | 14436 | 0.1644 | 0.0534 | |
| GSE53624 | HDDC3 | 374659 | 14436 | 0.0459 | 0.6796 | |
| GSE63941 | HDDC3 | 374659 | 227008_at | 0.6528 | 0.2396 | |
| GSE77861 | HDDC3 | 374659 | 227008_at | 0.0931 | 0.5898 | |
| GSE97050 | HDDC3 | 374659 | A_23_P65830 | 0.1080 | 0.6921 | |
| SRP007169 | HDDC3 | 374659 | RNAseq | -0.2258 | 0.5998 | |
| SRP008496 | HDDC3 | 374659 | RNAseq | -0.0559 | 0.8782 | |
| SRP064894 | HDDC3 | 374659 | RNAseq | 0.1674 | 0.5931 | |
| SRP133303 | HDDC3 | 374659 | RNAseq | -0.0083 | 0.9678 | |
| SRP159526 | HDDC3 | 374659 | RNAseq | 0.5981 | 0.0030 | |
| SRP193095 | HDDC3 | 374659 | RNAseq | -0.1843 | 0.1608 | |
| SRP219564 | HDDC3 | 374659 | RNAseq | 0.8825 | 0.0912 | |
| TCGA | HDDC3 | 374659 | RNAseq | -0.0925 | 0.3432 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HDDC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HDDC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HDDC3 | 374659 | 8 | 2 | 20 | |
| GSE20123 | HDDC3 | 374659 | 8 | 2 | 20 | |
| GSE43470 | HDDC3 | 374659 | 5 | 5 | 33 | |
| GSE46452 | HDDC3 | 374659 | 3 | 7 | 49 | |
| GSE47630 | HDDC3 | 374659 | 8 | 11 | 21 | |
| GSE54993 | HDDC3 | 374659 | 4 | 6 | 60 | |
| GSE54994 | HDDC3 | 374659 | 7 | 7 | 39 | |
| GSE60625 | HDDC3 | 374659 | 4 | 0 | 7 | |
| GSE74703 | HDDC3 | 374659 | 4 | 4 | 28 | |
| GSE74704 | HDDC3 | 374659 | 4 | 2 | 14 | |
| TCGA | HDDC3 | 374659 | 18 | 12 | 66 |
Total number of gains: 73; Total number of losses: 58; Total Number of normals: 357.
Somatic mutations of HDDC3:
Generating mutation plots.
Highly correlated genes for HDDC3:
Showing top 20/263 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HDDC3 | DRAM2 | 0.739677 | 3 | 0 | 3 |
| HDDC3 | CDC42SE2 | 0.733564 | 3 | 0 | 3 |
| HDDC3 | NAT10 | 0.730534 | 4 | 0 | 3 |
| HDDC3 | TADA3 | 0.724982 | 3 | 0 | 3 |
| HDDC3 | RRM1 | 0.72326 | 3 | 0 | 3 |
| HDDC3 | GAS2L1 | 0.71942 | 3 | 0 | 3 |
| HDDC3 | THOP1 | 0.711454 | 3 | 0 | 3 |
| HDDC3 | MRPS34 | 0.708433 | 4 | 0 | 4 |
| HDDC3 | LGALS8 | 0.708227 | 3 | 0 | 3 |
| HDDC3 | SNAP23 | 0.704981 | 3 | 0 | 3 |
| HDDC3 | RP9 | 0.699109 | 3 | 0 | 3 |
| HDDC3 | BTBD6 | 0.697997 | 3 | 0 | 3 |
| HDDC3 | ABCF1 | 0.696636 | 3 | 0 | 3 |
| HDDC3 | ATIC | 0.696518 | 3 | 0 | 3 |
| HDDC3 | USP42 | 0.694133 | 3 | 0 | 3 |
| HDDC3 | C9orf40 | 0.690503 | 3 | 0 | 3 |
| HDDC3 | CCNB1IP1 | 0.687954 | 3 | 0 | 3 |
| HDDC3 | ETS2 | 0.68585 | 3 | 0 | 3 |
| HDDC3 | ACYP1 | 0.679033 | 3 | 0 | 3 |
| HDDC3 | AKIP1 | 0.677261 | 3 | 0 | 3 |
For details and further investigation, click here
