| Full name: cytosolic iron-sulfur assembly component 1 | Alias Symbol: CIA1 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 9391 | HGNC ID: HGNC:14280 | Ensembl Gene: ENSG00000144021 | OMIM ID: 604333 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CIAO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CIAO1 | 9391 | 203536_s_at | 0.6838 | 0.0474 | |
| GSE20347 | CIAO1 | 9391 | 203536_s_at | 0.4637 | 0.0017 | |
| GSE23400 | CIAO1 | 9391 | 203536_s_at | 0.5111 | 0.0000 | |
| GSE26886 | CIAO1 | 9391 | 203536_s_at | 0.3497 | 0.0115 | |
| GSE29001 | CIAO1 | 9391 | 217501_at | 0.1148 | 0.5784 | |
| GSE38129 | CIAO1 | 9391 | 217501_at | 0.1735 | 0.0714 | |
| GSE45670 | CIAO1 | 9391 | 217501_at | 0.0800 | 0.5290 | |
| GSE63941 | CIAO1 | 9391 | 203536_s_at | 1.0210 | 0.0306 | |
| GSE77861 | CIAO1 | 9391 | 217501_at | 0.4206 | 0.0151 | |
| GSE97050 | CIAO1 | 9391 | A_33_P3306397 | -0.1434 | 0.5036 | |
| SRP007169 | CIAO1 | 9391 | RNAseq | 0.1805 | 0.6649 | |
| SRP008496 | CIAO1 | 9391 | RNAseq | 0.4928 | 0.0453 | |
| SRP064894 | CIAO1 | 9391 | RNAseq | 0.1418 | 0.1433 | |
| SRP133303 | CIAO1 | 9391 | RNAseq | 0.2898 | 0.0003 | |
| SRP159526 | CIAO1 | 9391 | RNAseq | 0.3564 | 0.0763 | |
| SRP193095 | CIAO1 | 9391 | RNAseq | 0.0718 | 0.2948 | |
| SRP219564 | CIAO1 | 9391 | RNAseq | 0.5812 | 0.2890 | |
| TCGA | CIAO1 | 9391 | RNAseq | -0.0163 | 0.7180 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CIAO1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CIAO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CIAO1 | 9391 | 6 | 2 | 22 | |
| GSE20123 | CIAO1 | 9391 | 6 | 2 | 22 | |
| GSE43470 | CIAO1 | 9391 | 2 | 3 | 38 | |
| GSE46452 | CIAO1 | 9391 | 2 | 3 | 54 | |
| GSE47630 | CIAO1 | 9391 | 7 | 0 | 33 | |
| GSE54993 | CIAO1 | 9391 | 0 | 6 | 64 | |
| GSE54994 | CIAO1 | 9391 | 11 | 0 | 42 | |
| GSE60625 | CIAO1 | 9391 | 0 | 3 | 8 | |
| GSE74703 | CIAO1 | 9391 | 2 | 2 | 32 | |
| GSE74704 | CIAO1 | 9391 | 4 | 1 | 15 | |
| TCGA | CIAO1 | 9391 | 35 | 3 | 58 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of CIAO1:
Generating mutation plots.
Highly correlated genes for CIAO1:
Showing top 20/1030 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CIAO1 | DHX33 | 0.841 | 3 | 0 | 3 |
| CIAO1 | CPNE8 | 0.824288 | 3 | 0 | 3 |
| CIAO1 | MAP4K4 | 0.815046 | 3 | 0 | 3 |
| CIAO1 | TMEM138 | 0.804514 | 3 | 0 | 3 |
| CIAO1 | DNAH14 | 0.792976 | 3 | 0 | 3 |
| CIAO1 | CCM2 | 0.792904 | 3 | 0 | 3 |
| CIAO1 | FOXN2 | 0.782719 | 3 | 0 | 3 |
| CIAO1 | YWHAG | 0.775449 | 4 | 0 | 3 |
| CIAO1 | GNA13 | 0.77113 | 3 | 0 | 3 |
| CIAO1 | MZT1 | 0.765269 | 3 | 0 | 3 |
| CIAO1 | CMTM4 | 0.76064 | 4 | 0 | 4 |
| CIAO1 | LRRC58 | 0.759517 | 3 | 0 | 3 |
| CIAO1 | SAMD1 | 0.759296 | 4 | 0 | 4 |
| CIAO1 | TRMT6 | 0.759148 | 4 | 0 | 4 |
| CIAO1 | THOP1 | 0.754324 | 4 | 0 | 4 |
| CIAO1 | BUB1 | 0.750079 | 5 | 0 | 5 |
| CIAO1 | ARL13B | 0.744686 | 3 | 0 | 3 |
| CIAO1 | OCIAD1 | 0.744185 | 3 | 0 | 3 |
| CIAO1 | CYP27C1 | 0.738094 | 3 | 0 | 3 |
| CIAO1 | ZNF577 | 0.737649 | 3 | 0 | 3 |
For details and further investigation, click here
