TGFB1

 

Full name: transforming growth factor beta 1 Alias Symbol: CED|TGFbeta
Type: protein-coding gene Cytoband: 19q13.2
Entrez ID: 7040 HGNC ID: HGNC:11766 Ensembl Gene: ENSG00000105329 OMIM ID: 190180
Drug and gene relationship at DGIdb

 

TGFB1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa04380Osteoclast differentiation
hsa04390Hippo signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa05321Inflammatory bowel disease (IBD)

 

Expression of TGFB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TGFB1 7040 203085_s_at 0.8901 0.1568
GSE20347 TGFB1 7040 203085_s_at 0.5923 0.0290
GSE23400 TGFB1 7040 203085_s_at 0.5989 0.0000
GSE26886 TGFB1 7040 203084_at 0.1874 0.0768
GSE29001 TGFB1 7040 203084_at -0.2087 0.0752
GSE38129 TGFB1 7040 203085_s_at 0.6385 0.0022
GSE45670 TGFB1 7040 203085_s_at 0.6171 0.0144
GSE63941 TGFB1 7040 203085_s_at 0.5802 0.4992
GSE77861 TGFB1 7040 203085_s_at 1.0017 0.0982
GSE97050 TGFB1 7040 A_24_P79054 1.2063 0.0781
SRP007169 TGFB1 7040 RNAseq 0.1141 0.7965
SRP008496 TGFB1 7040 RNAseq -0.4655 0.2019
SRP064894 TGFB1 7040 RNAseq 0.4340 0.0734
SRP133303 TGFB1 7040 RNAseq 0.9109 0.0001
SRP159526 TGFB1 7040 RNAseq 0.6597 0.0563
SRP193095 TGFB1 7040 RNAseq 0.3712 0.1275
SRP219564 TGFB1 7040 RNAseq 0.3967 0.3414
TCGA TGFB1 7040 RNAseq 0.4098 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TGFB1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of TGFB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TGFB1 7040 4 4 22
GSE20123 TGFB1 7040 4 3 23
GSE43470 TGFB1 7040 3 11 29
GSE46452 TGFB1 7040 48 1 10
GSE47630 TGFB1 7040 9 5 26
GSE54993 TGFB1 7040 17 4 49
GSE54994 TGFB1 7040 7 11 35
GSE60625 TGFB1 7040 9 0 2
GSE74703 TGFB1 7040 3 7 26
GSE74704 TGFB1 7040 4 1 15
TCGA TGFB1 7040 14 16 66

Total number of gains: 122; Total number of losses: 63; Total Number of normals: 303.  

 

Somatic mutations of TGFB1:

 

Generating mutation plots.

 

Highly correlated genes for TGFB1:

 

Showing top 20/529 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TGFB1ZDHHC90.775722303
TGFB1DCBLD10.775494404
TGFB1CDC25C0.774226303
TGFB1MOB3A0.766711303
TGFB1PPP1R9B0.763613303
TGFB1LMNB10.749819303
TGFB1XPR10.747159404
TGFB1OAF0.740608303
TGFB1HOXA70.723301303
TGFB1LARP10.720742404
TGFB1SH3PXD2B0.714679504
TGFB1C11orf800.705989303
TGFB1CTSH0.704935303
TGFB1TMEM540.704715404
TGFB1MICALCL0.703139303
TGFB1CAMKK10.702966303
TGFB1THOP10.70269303
TGFB1TNK10.702613404
TGFB1IKBKG0.69985303
TGFB1BCAR10.69836404

For details and further investigation, click here