| Full name: TIMP metallopeptidase inhibitor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p25.2 | ||
| Entrez ID: 7079 | HGNC ID: HGNC:11823 | Ensembl Gene: ENSG00000157150 | OMIM ID: 601915 |
| Drug and gene relationship at DGIdb | |||
Expression of TIMP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIMP4 | 7079 | 206243_at | -1.0620 | 0.3409 | |
| GSE20347 | TIMP4 | 7079 | 206243_at | 0.0066 | 0.9558 | |
| GSE23400 | TIMP4 | 7079 | 206243_at | -0.1868 | 0.0001 | |
| GSE26886 | TIMP4 | 7079 | 206243_at | 0.0811 | 0.5843 | |
| GSE29001 | TIMP4 | 7079 | 206243_at | -0.1034 | 0.4245 | |
| GSE38129 | TIMP4 | 7079 | 206243_at | -0.7306 | 0.0371 | |
| GSE45670 | TIMP4 | 7079 | 206243_at | -0.6054 | 0.0000 | |
| GSE53622 | TIMP4 | 7079 | 1909 | -1.6564 | 0.0000 | |
| GSE53624 | TIMP4 | 7079 | 1909 | -1.1498 | 0.0000 | |
| GSE63941 | TIMP4 | 7079 | 206243_at | -0.6639 | 0.2096 | |
| GSE77861 | TIMP4 | 7079 | 206243_at | 0.0455 | 0.7509 | |
| GSE97050 | TIMP4 | 7079 | A_32_P70315 | -0.1652 | 0.5406 | |
| SRP064894 | TIMP4 | 7079 | RNAseq | 0.6761 | 0.2350 | |
| SRP159526 | TIMP4 | 7079 | RNAseq | -0.8565 | 0.1902 | |
| SRP219564 | TIMP4 | 7079 | RNAseq | -0.5234 | 0.6198 | |
| TCGA | TIMP4 | 7079 | RNAseq | -1.4907 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TIMP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIMP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIMP4 | 7079 | 1 | 17 | 12 | |
| GSE20123 | TIMP4 | 7079 | 1 | 18 | 11 | |
| GSE43470 | TIMP4 | 7079 | 0 | 21 | 22 | |
| GSE46452 | TIMP4 | 7079 | 2 | 17 | 40 | |
| GSE47630 | TIMP4 | 7079 | 2 | 23 | 15 | |
| GSE54993 | TIMP4 | 7079 | 6 | 1 | 63 | |
| GSE54994 | TIMP4 | 7079 | 1 | 33 | 19 | |
| GSE60625 | TIMP4 | 7079 | 5 | 0 | 6 | |
| GSE74703 | TIMP4 | 7079 | 0 | 17 | 19 | |
| GSE74704 | TIMP4 | 7079 | 1 | 10 | 9 | |
| TCGA | TIMP4 | 7079 | 1 | 68 | 27 |
Total number of gains: 20; Total number of losses: 225; Total Number of normals: 243.
Somatic mutations of TIMP4:
Generating mutation plots.
Highly correlated genes for TIMP4:
Showing top 20/1028 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIMP4 | UBXN10 | 0.806096 | 3 | 0 | 3 |
| TIMP4 | CD99L2 | 0.790101 | 3 | 0 | 3 |
| TIMP4 | TNFSF12 | 0.781189 | 3 | 0 | 3 |
| TIMP4 | CYP4V2 | 0.772231 | 3 | 0 | 3 |
| TIMP4 | TCEAL6 | 0.771218 | 3 | 0 | 3 |
| TIMP4 | ABCA6 | 0.766269 | 8 | 0 | 8 |
| TIMP4 | HABP4 | 0.763176 | 5 | 0 | 5 |
| TIMP4 | LRFN5 | 0.758145 | 4 | 0 | 4 |
| TIMP4 | NOVA1 | 0.756524 | 6 | 0 | 6 |
| TIMP4 | AMOTL1 | 0.747351 | 3 | 0 | 3 |
| TIMP4 | FIBIN | 0.745042 | 4 | 0 | 4 |
| TIMP4 | XKR4 | 0.741817 | 5 | 0 | 5 |
| TIMP4 | ZNF583 | 0.740392 | 3 | 0 | 3 |
| TIMP4 | EBF1 | 0.739574 | 5 | 0 | 5 |
| TIMP4 | CCDC88A | 0.739391 | 3 | 0 | 3 |
| TIMP4 | LYVE1 | 0.739021 | 9 | 0 | 8 |
| TIMP4 | RSPO3 | 0.737503 | 5 | 0 | 5 |
| TIMP4 | GDF10 | 0.737403 | 6 | 0 | 6 |
| TIMP4 | MICU3 | 0.734662 | 4 | 0 | 4 |
| TIMP4 | KLF11 | 0.732906 | 4 | 0 | 4 |
For details and further investigation, click here
