| Full name: tight junction protein 2 | Alias Symbol: ZO-2|X104|ZO2 | ||
| Type: protein-coding gene | Cytoband: 9q21.11 | ||
| Entrez ID: 9414 | HGNC ID: HGNC:11828 | Ensembl Gene: ENSG00000119139 | OMIM ID: 607709 |
| Drug and gene relationship at DGIdb | |||
TJP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of TJP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TJP2 | 9414 | 202085_at | -0.9121 | 0.0541 | |
| GSE20347 | TJP2 | 9414 | 202085_at | -1.1714 | 0.0000 | |
| GSE23400 | TJP2 | 9414 | 202085_at | -0.9891 | 0.0000 | |
| GSE26886 | TJP2 | 9414 | 202085_at | -1.6776 | 0.0000 | |
| GSE29001 | TJP2 | 9414 | 202085_at | -0.9195 | 0.0166 | |
| GSE38129 | TJP2 | 9414 | 202085_at | -0.9815 | 0.0000 | |
| GSE45670 | TJP2 | 9414 | 202085_at | -0.2742 | 0.1304 | |
| GSE53622 | TJP2 | 9414 | 46736 | -1.4678 | 0.0000 | |
| GSE53624 | TJP2 | 9414 | 23465 | -1.3293 | 0.0000 | |
| GSE63941 | TJP2 | 9414 | 202085_at | 1.2151 | 0.2902 | |
| GSE77861 | TJP2 | 9414 | 202085_at | -0.9010 | 0.0460 | |
| GSE97050 | TJP2 | 9414 | A_23_P9293 | -0.2549 | 0.2308 | |
| SRP007169 | TJP2 | 9414 | RNAseq | -0.6811 | 0.1684 | |
| SRP008496 | TJP2 | 9414 | RNAseq | -1.0492 | 0.0010 | |
| SRP064894 | TJP2 | 9414 | RNAseq | -1.0611 | 0.0000 | |
| SRP133303 | TJP2 | 9414 | RNAseq | -1.0552 | 0.0000 | |
| SRP159526 | TJP2 | 9414 | RNAseq | -1.4934 | 0.0004 | |
| SRP193095 | TJP2 | 9414 | RNAseq | -0.9205 | 0.0000 | |
| SRP219564 | TJP2 | 9414 | RNAseq | -0.9682 | 0.0005 | |
| TCGA | TJP2 | 9414 | RNAseq | -0.2275 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by TJP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TJP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TJP2 | 9414 | 6 | 10 | 14 | |
| GSE20123 | TJP2 | 9414 | 6 | 10 | 14 | |
| GSE43470 | TJP2 | 9414 | 6 | 5 | 32 | |
| GSE46452 | TJP2 | 9414 | 7 | 14 | 38 | |
| GSE47630 | TJP2 | 9414 | 1 | 19 | 20 | |
| GSE54993 | TJP2 | 9414 | 5 | 1 | 64 | |
| GSE54994 | TJP2 | 9414 | 4 | 13 | 36 | |
| GSE60625 | TJP2 | 9414 | 0 | 0 | 11 | |
| GSE74703 | TJP2 | 9414 | 5 | 4 | 27 | |
| GSE74704 | TJP2 | 9414 | 3 | 7 | 10 | |
| TCGA | TJP2 | 9414 | 19 | 28 | 49 |
Total number of gains: 62; Total number of losses: 111; Total Number of normals: 315.
Somatic mutations of TJP2:
Generating mutation plots.
Highly correlated genes for TJP2:
Showing top 20/792 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TJP2 | FAM163B | 0.775913 | 3 | 0 | 3 |
| TJP2 | KRT78 | 0.774177 | 6 | 0 | 6 |
| TJP2 | MYO5B | 0.772046 | 7 | 0 | 7 |
| TJP2 | EPS8L2 | 0.769449 | 12 | 0 | 12 |
| TJP2 | FAM214A | 0.763035 | 6 | 0 | 6 |
| TJP2 | RAB10 | 0.754789 | 6 | 0 | 6 |
| TJP2 | ECM1 | 0.754144 | 11 | 0 | 11 |
| TJP2 | SNORA68 | 0.75177 | 4 | 0 | 4 |
| TJP2 | TP53I3 | 0.751753 | 10 | 0 | 10 |
| TJP2 | NCR1 | 0.748686 | 3 | 0 | 3 |
| TJP2 | NPEPPS | 0.748612 | 10 | 0 | 10 |
| TJP2 | CAST | 0.748547 | 10 | 0 | 10 |
| TJP2 | MXD1 | 0.748143 | 12 | 0 | 12 |
| TJP2 | BCDIN3D | 0.747693 | 3 | 0 | 3 |
| TJP2 | SASH1 | 0.746225 | 10 | 0 | 10 |
| TJP2 | MGLL | 0.746188 | 10 | 0 | 10 |
| TJP2 | VSIG10L | 0.745603 | 7 | 0 | 7 |
| TJP2 | CHP1 | 0.74345 | 10 | 0 | 10 |
| TJP2 | PTK6 | 0.738811 | 12 | 0 | 11 |
| TJP2 | C5orf66-AS1 | 0.737724 | 6 | 0 | 6 |
For details and further investigation, click here
