NPEPPS

 

Full name: aminopeptidase puromycin sensitive Alias Symbol: PSA|MP100
Type: protein-coding gene Cytoband: 17q21.32
Entrez ID: 9520 HGNC ID: HGNC:7900 Ensembl Gene: ENSG00000141279 OMIM ID: 606793
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of NPEPPS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NPEPPS 9520 201454_s_at -0.9357 0.0559
GSE20347 NPEPPS 9520 201454_s_at -1.6767 0.0000
GSE23400 NPEPPS 9520 201454_s_at -1.3039 0.0000
GSE26886 NPEPPS 9520 201454_s_at -2.7706 0.0000
GSE29001 NPEPPS 9520 201454_s_at -1.6038 0.0007
GSE38129 NPEPPS 9520 201454_s_at -1.1009 0.0000
GSE45670 NPEPPS 9520 201454_s_at -0.3062 0.1801
GSE53622 NPEPPS 9520 23918 -1.0094 0.0000
GSE53624 NPEPPS 9520 81335 -1.2000 0.0000
GSE63941 NPEPPS 9520 201455_s_at -0.3033 0.4934
GSE77861 NPEPPS 9520 201455_s_at -0.6504 0.0106
GSE97050 NPEPPS 9520 A_24_P409346 -0.3941 0.2989
SRP007169 NPEPPS 9520 RNAseq -2.2781 0.0000
SRP008496 NPEPPS 9520 RNAseq -2.4588 0.0000
SRP064894 NPEPPS 9520 RNAseq -1.6108 0.0000
SRP133303 NPEPPS 9520 RNAseq -1.2196 0.0000
SRP159526 NPEPPS 9520 RNAseq -1.5149 0.0000
SRP193095 NPEPPS 9520 RNAseq -1.5149 0.0000
SRP219564 NPEPPS 9520 RNAseq -1.7780 0.0001
TCGA NPEPPS 9520 RNAseq -0.0322 0.5382

Upregulated datasets: 0; Downregulated datasets: 14.  

 

Survival by NPEPPS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NPEPPS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NPEPPS 9520 5 2 23
GSE20123 NPEPPS 9520 5 2 23
GSE43470 NPEPPS 9520 1 2 40
GSE46452 NPEPPS 9520 32 0 27
GSE47630 NPEPPS 9520 9 0 31
GSE54993 NPEPPS 9520 2 4 64
GSE54994 NPEPPS 9520 11 5 37
GSE60625 NPEPPS 9520 4 0 7
GSE74703 NPEPPS 9520 1 1 34
GSE74704 NPEPPS 9520 4 1 15
TCGA NPEPPS 9520 27 6 63

Total number of gains: 101; Total number of losses: 23; Total Number of normals: 364.  

 

Somatic mutations of NPEPPS:

 

Generating mutation plots.

 

Highly correlated genes for NPEPPS:

 

Showing top 20/1796 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NPEPPSRAET1E0.832496606
NPEPPSENDOU0.82780511011
NPEPPSTP53I30.82621511011
NPEPPSGYS20.82444210010
NPEPPSBNIPL0.822038707
NPEPPSSFTA20.821242404
NPEPPSKRT780.820483707
NPEPPSTMOD30.81993711011
NPEPPSMPZL30.815407707
NPEPPSCAPN140.81338606
NPEPPSEHD30.81244911011
NPEPPSEPS8L20.81166510010
NPEPPSEPS8L10.81120811011
NPEPPSPHACTR40.80829311011
NPEPPSNAGK0.80747611011
NPEPPSPTK60.80627710010
NPEPPSECM10.80563111010
NPEPPSGRPEL20.80395707
NPEPPSCLIC30.8034281009
NPEPPSC18orf250.80321411011

For details and further investigation, click here