| Full name: monoglyceride lipase | Alias Symbol: HU-K5|MGL | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 11343 | HGNC ID: HGNC:17038 | Ensembl Gene: ENSG00000074416 | OMIM ID: 609699 |
| Drug and gene relationship at DGIdb | |||
Expression of MGLL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MGLL | 11343 | 211026_s_at | -2.3969 | 0.0171 | |
| GSE20347 | MGLL | 11343 | 211026_s_at | -3.2338 | 0.0000 | |
| GSE23400 | MGLL | 11343 | 211026_s_at | -1.9209 | 0.0000 | |
| GSE26886 | MGLL | 11343 | 225102_at | -3.2597 | 0.0000 | |
| GSE29001 | MGLL | 11343 | 211026_s_at | -2.8396 | 0.0000 | |
| GSE38129 | MGLL | 11343 | 211026_s_at | -2.8463 | 0.0000 | |
| GSE45670 | MGLL | 11343 | 211026_s_at | -1.6439 | 0.0011 | |
| GSE53622 | MGLL | 11343 | 19378 | -2.9364 | 0.0000 | |
| GSE53624 | MGLL | 11343 | 19378 | -3.0425 | 0.0000 | |
| GSE63941 | MGLL | 11343 | 225102_at | -2.9785 | 0.0035 | |
| GSE77861 | MGLL | 11343 | 211026_s_at | -1.8465 | 0.0132 | |
| GSE97050 | MGLL | 11343 | A_24_P226008 | -1.6078 | 0.0828 | |
| SRP007169 | MGLL | 11343 | RNAseq | -3.4574 | 0.0000 | |
| SRP008496 | MGLL | 11343 | RNAseq | -3.5013 | 0.0000 | |
| SRP064894 | MGLL | 11343 | RNAseq | -2.3902 | 0.0000 | |
| SRP133303 | MGLL | 11343 | RNAseq | -2.7011 | 0.0000 | |
| SRP159526 | MGLL | 11343 | RNAseq | -2.7797 | 0.0000 | |
| SRP193095 | MGLL | 11343 | RNAseq | -2.3373 | 0.0000 | |
| SRP219564 | MGLL | 11343 | RNAseq | -2.0489 | 0.0001 | |
| TCGA | MGLL | 11343 | RNAseq | -0.4058 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 18.
Survival by MGLL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MGLL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MGLL | 11343 | 17 | 0 | 13 | |
| GSE20123 | MGLL | 11343 | 17 | 0 | 13 | |
| GSE43470 | MGLL | 11343 | 19 | 0 | 24 | |
| GSE46452 | MGLL | 11343 | 14 | 5 | 40 | |
| GSE47630 | MGLL | 11343 | 17 | 4 | 19 | |
| GSE54993 | MGLL | 11343 | 2 | 7 | 61 | |
| GSE54994 | MGLL | 11343 | 31 | 3 | 19 | |
| GSE60625 | MGLL | 11343 | 0 | 6 | 5 | |
| GSE74703 | MGLL | 11343 | 17 | 0 | 19 | |
| GSE74704 | MGLL | 11343 | 13 | 0 | 7 | |
| TCGA | MGLL | 11343 | 56 | 6 | 34 |
Total number of gains: 203; Total number of losses: 31; Total Number of normals: 254.
Somatic mutations of MGLL:
Generating mutation plots.
Highly correlated genes for MGLL:
Showing top 20/1682 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MGLL | SH3BGRL2 | 0.884257 | 7 | 0 | 7 |
| MGLL | SPINK7 | 0.882243 | 6 | 0 | 6 |
| MGLL | CYSRT1 | 0.881431 | 6 | 0 | 6 |
| MGLL | VSIG10L | 0.877472 | 6 | 0 | 6 |
| MGLL | KRT78 | 0.876032 | 7 | 0 | 7 |
| MGLL | SNORA68 | 0.871269 | 4 | 0 | 4 |
| MGLL | SCNN1B | 0.866138 | 10 | 0 | 10 |
| MGLL | GDPD3 | 0.857798 | 10 | 0 | 10 |
| MGLL | SASH1 | 0.857523 | 12 | 0 | 12 |
| MGLL | FAM214A | 0.85747 | 6 | 0 | 6 |
| MGLL | PPP1R3C | 0.856644 | 12 | 0 | 12 |
| MGLL | CRISP3 | 0.856305 | 11 | 0 | 11 |
| MGLL | MALL | 0.847174 | 10 | 0 | 10 |
| MGLL | TMPRSS11E | 0.843931 | 10 | 0 | 10 |
| MGLL | PLEKHM1 | 0.842216 | 11 | 0 | 11 |
| MGLL | CLIC3 | 0.841403 | 9 | 0 | 9 |
| MGLL | EHD3 | 0.838195 | 12 | 0 | 12 |
| MGLL | GYS2 | 0.837261 | 10 | 0 | 10 |
| MGLL | CLCA4 | 0.835516 | 10 | 0 | 10 |
| MGLL | CAST | 0.835107 | 11 | 0 | 11 |
For details and further investigation, click here
