| Full name: RAB10, member RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 10890 | HGNC ID: HGNC:9759 | Ensembl Gene: ENSG00000084733 | OMIM ID: 612672 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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RAB10 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway |
Expression of RAB10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB10 | 10890 | 222980_at | -0.5957 | 0.3031 | |
| GSE26886 | RAB10 | 10890 | 222980_at | -1.3082 | 0.0000 | |
| GSE45670 | RAB10 | 10890 | 222981_s_at | -0.1666 | 0.4659 | |
| GSE53622 | RAB10 | 10890 | 13659 | -1.3644 | 0.0000 | |
| GSE53624 | RAB10 | 10890 | 13659 | -1.4023 | 0.0000 | |
| GSE63941 | RAB10 | 10890 | 222980_at | -0.1130 | 0.7228 | |
| GSE77861 | RAB10 | 10890 | 222980_at | -0.7656 | 0.0098 | |
| GSE97050 | RAB10 | 10890 | A_23_P165879 | -0.8897 | 0.1107 | |
| SRP007169 | RAB10 | 10890 | RNAseq | -3.0909 | 0.0000 | |
| SRP008496 | RAB10 | 10890 | RNAseq | -2.4930 | 0.0000 | |
| SRP064894 | RAB10 | 10890 | RNAseq | -1.8143 | 0.0000 | |
| SRP133303 | RAB10 | 10890 | RNAseq | -1.1757 | 0.0000 | |
| SRP159526 | RAB10 | 10890 | RNAseq | -1.4195 | 0.0002 | |
| SRP193095 | RAB10 | 10890 | RNAseq | -1.3708 | 0.0000 | |
| SRP219564 | RAB10 | 10890 | RNAseq | -1.5578 | 0.0059 | |
| TCGA | RAB10 | 10890 | RNAseq | 0.1045 | 0.0483 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by RAB10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB10 | 10890 | 11 | 2 | 17 | |
| GSE20123 | RAB10 | 10890 | 11 | 2 | 17 | |
| GSE43470 | RAB10 | 10890 | 3 | 1 | 39 | |
| GSE46452 | RAB10 | 10890 | 3 | 4 | 52 | |
| GSE47630 | RAB10 | 10890 | 8 | 0 | 32 | |
| GSE54993 | RAB10 | 10890 | 0 | 6 | 64 | |
| GSE54994 | RAB10 | 10890 | 10 | 0 | 43 | |
| GSE60625 | RAB10 | 10890 | 0 | 3 | 8 | |
| GSE74703 | RAB10 | 10890 | 3 | 0 | 33 | |
| GSE74704 | RAB10 | 10890 | 9 | 1 | 10 | |
| TCGA | RAB10 | 10890 | 36 | 3 | 57 |
Total number of gains: 94; Total number of losses: 22; Total Number of normals: 372.
Somatic mutations of RAB10:
Generating mutation plots.
Highly correlated genes for RAB10:
Showing top 20/1444 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB10 | CYSRT1 | 0.888095 | 6 | 0 | 6 |
| RAB10 | KRT78 | 0.853088 | 7 | 0 | 7 |
| RAB10 | GDPD3 | 0.852771 | 7 | 0 | 7 |
| RAB10 | TMOD3 | 0.846028 | 7 | 0 | 7 |
| RAB10 | ENDOU | 0.840314 | 7 | 0 | 7 |
| RAB10 | PRAMEF10 | 0.830146 | 3 | 0 | 3 |
| RAB10 | APOBEC1 | 0.829304 | 3 | 0 | 3 |
| RAB10 | MUC15 | 0.828143 | 7 | 0 | 7 |
| RAB10 | MPZL3 | 0.827484 | 7 | 0 | 7 |
| RAB10 | FRMD4B | 0.82656 | 6 | 0 | 6 |
| RAB10 | VSIG10L | 0.825232 | 7 | 0 | 7 |
| RAB10 | SERPINB1 | 0.824624 | 8 | 0 | 7 |
| RAB10 | EPS8L1 | 0.824439 | 7 | 0 | 7 |
| RAB10 | PPL | 0.824092 | 8 | 0 | 7 |
| RAB10 | TGM3 | 0.823888 | 7 | 0 | 7 |
| RAB10 | CHP1 | 0.823194 | 6 | 0 | 6 |
| RAB10 | TMPRSS11E | 0.82274 | 7 | 0 | 7 |
| RAB10 | ANXA9 | 0.818433 | 7 | 0 | 7 |
| RAB10 | SLC35C1 | 0.817748 | 6 | 0 | 6 |
| RAB10 | FLG | 0.817705 | 7 | 0 | 7 |
For details and further investigation, click here
