Full name: calpastatin	Alias Symbol:
Type: protein-coding gene	Cytoband: 5q15
Entrez ID: 831	HGNC ID: HGNC:1515	Ensembl Gene: ENSG00000153113	OMIM ID: 114090
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of CAST:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	CAST	831	212586_at	-1.4375	0.0086	Show
GSE20347	CAST	831	207467_x_at	-1.8732	0.0000	Show
GSE23400	CAST	831	212586_at	-1.2519	0.0000	Show
GSE26886	CAST	831	207467_x_at	-1.6198	0.0000	Show
GSE29001	CAST	831	207467_x_at	-1.3600	0.0001	Show
GSE38129	CAST	831	207467_x_at	-1.2951	0.0000	Show
GSE45670	CAST	831	207467_x_at	-0.6418	0.0024	Show
GSE53622	CAST	831	65591	-1.5889	0.0000	Show
GSE53624	CAST	831	65591	-1.7871	0.0000	Show
GSE63941	CAST	831	207467_x_at	-0.0458	0.9437	Show
GSE77861	CAST	831	212586_at	-1.4894	0.0003	Show
GSE97050	CAST	831	A_23_P434352	-0.8980	0.0631	Show
SRP007169	CAST	831	RNAseq	-2.6143	0.0000	Show
SRP008496	CAST	831	RNAseq	-2.5976	0.0000	Show
SRP064894	CAST	831	RNAseq	-2.2568	0.0000	Show
SRP133303	CAST	831	RNAseq	-1.3057	0.0000	Show
SRP159526	CAST	831	RNAseq	-2.1476	0.0000	Show
SRP193095	CAST	831	RNAseq	-1.8610	0.0000	Show
SRP219564	CAST	831	RNAseq	-1.8113	0.0014	Show
TCGA	CAST	831	RNAseq	-0.0599	0.3388	Show

Upregulated datasets: 0; Downregulated datasets: 16.  Download Data

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Survival by CAST expression:

 

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Copy number change of CAST:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	CAST	831	1	13	16	Show
GSE20123	CAST	831	1	13	16	Show
GSE43470	CAST	831	3	9	31	Show
GSE46452	CAST	831	0	28	31	Show
GSE47630	CAST	831	0	20	20	Show
GSE54993	CAST	831	8	1	61	Show
GSE54994	CAST	831	1	18	34	Show
GSE60625	CAST	831	0	0	11	Show
GSE74703	CAST	831	2	7	27	Show
GSE74704	CAST	831	1	7	12	Show
TCGA	CAST	831	3	44	49	Show

Total number of gains: 20; Total number of losses: 160; Total Number of normals: 308.  Download Data

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Somatic mutations of CAST:

 

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Highly correlated genes for CAST:

 

Showing top 20/1997 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
CAST	SFTA2	0.863986	4	0	4
CAST	MPP7	0.856861	7	0	7
CAST	SASH1	0.856715	11	0	11
CAST	CRISP3	0.851908	11	0	11
CAST	GBP6	0.846609	4	0	4
CAST	RAET1E	0.845936	6	0	6
CAST	ENDOU	0.84559	11	0	11
CAST	CPEB3	0.844781	10	0	10
CAST	DOCK9	0.842041	11	0	11
CAST	GYS2	0.841053	10	0	10
CAST	HCG22	0.837707	6	0	6
CAST	PRSS27	0.835888	6	0	6
CAST	MGLL	0.835107	11	0	11
CAST	TRIP10	0.833921	11	0	11
CAST	RANBP9	0.832686	11	0	11
CAST	SPINK7	0.831635	6	0	6
CAST	CA13	0.831333	3	0	3
CAST	C5orf66-AS1	0.830375	6	0	6
CAST	EHD3	0.830158	11	0	11
CAST	KANK1	0.825975	11	0	11

For details and further investigation, click here