| Full name: TLE family member 1, transcriptional corepressor | Alias Symbol: ESG1|GRG1|ESG | ||
| Type: protein-coding gene | Cytoband: 9q21.32 | ||
| Entrez ID: 7088 | HGNC ID: HGNC:11837 | Ensembl Gene: ENSG00000196781 | OMIM ID: 600189 |
| Drug and gene relationship at DGIdb | |||
Expression of TLE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLE1 | 7088 | 203221_at | -0.1174 | 0.7954 | |
| GSE20347 | TLE1 | 7088 | 203221_at | 0.2203 | 0.3087 | |
| GSE23400 | TLE1 | 7088 | 203221_at | 0.1346 | 0.0456 | |
| GSE26886 | TLE1 | 7088 | 203221_at | 0.1418 | 0.2666 | |
| GSE29001 | TLE1 | 7088 | 203221_at | 0.4710 | 0.1405 | |
| GSE38129 | TLE1 | 7088 | 203221_at | -0.0047 | 0.9857 | |
| GSE45670 | TLE1 | 7088 | 203221_at | -0.0588 | 0.8339 | |
| GSE53622 | TLE1 | 7088 | 30046 | -1.0958 | 0.0000 | |
| GSE53624 | TLE1 | 7088 | 30046 | -0.4448 | 0.0000 | |
| GSE63941 | TLE1 | 7088 | 203221_at | -0.7858 | 0.3746 | |
| GSE77861 | TLE1 | 7088 | 203221_at | 0.9929 | 0.0116 | |
| GSE97050 | TLE1 | A_19_P00804020 | 0.1116 | 0.6255 | ||
| SRP007169 | TLE1 | 7088 | RNAseq | 1.3957 | 0.0005 | |
| SRP008496 | TLE1 | 7088 | RNAseq | 1.0467 | 0.0040 | |
| SRP064894 | TLE1 | 7088 | RNAseq | 0.2058 | 0.2319 | |
| SRP133303 | TLE1 | 7088 | RNAseq | 0.0486 | 0.8471 | |
| SRP159526 | TLE1 | 7088 | RNAseq | 0.4060 | 0.2121 | |
| SRP193095 | TLE1 | 7088 | RNAseq | 0.2784 | 0.1613 | |
| SRP219564 | TLE1 | 7088 | RNAseq | -0.0314 | 0.9508 | |
| TCGA | TLE1 | 7088 | RNAseq | -0.2983 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by TLE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLE1 | 7088 | 5 | 10 | 15 | |
| GSE20123 | TLE1 | 7088 | 5 | 10 | 15 | |
| GSE43470 | TLE1 | 7088 | 6 | 5 | 32 | |
| GSE46452 | TLE1 | 7088 | 6 | 14 | 39 | |
| GSE47630 | TLE1 | 7088 | 1 | 18 | 21 | |
| GSE54993 | TLE1 | 7088 | 4 | 2 | 64 | |
| GSE54994 | TLE1 | 7088 | 4 | 12 | 37 | |
| GSE60625 | TLE1 | 7088 | 0 | 0 | 11 | |
| GSE74703 | TLE1 | 7088 | 5 | 4 | 27 | |
| GSE74704 | TLE1 | 7088 | 3 | 7 | 10 | |
| TCGA | TLE1 | 7088 | 19 | 29 | 48 |
Total number of gains: 58; Total number of losses: 111; Total Number of normals: 319.
Somatic mutations of TLE1:
Generating mutation plots.
Highly correlated genes for TLE1:
Showing top 20/305 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLE1 | SGTB | 0.782817 | 3 | 0 | 3 |
| TLE1 | C11orf74 | 0.764342 | 3 | 0 | 3 |
| TLE1 | ZFAND3 | 0.734319 | 3 | 0 | 3 |
| TLE1 | HNRNPUL2 | 0.723848 | 3 | 0 | 3 |
| TLE1 | CERK | 0.723269 | 3 | 0 | 3 |
| TLE1 | DOCK11 | 0.721712 | 4 | 0 | 4 |
| TLE1 | ABI2 | 0.715815 | 3 | 0 | 3 |
| TLE1 | UBR1 | 0.710677 | 3 | 0 | 3 |
| TLE1 | USP14 | 0.699194 | 3 | 0 | 3 |
| TLE1 | MSI2 | 0.693152 | 3 | 0 | 3 |
| TLE1 | PIEZO1 | 0.692896 | 3 | 0 | 3 |
| TLE1 | SESTD1 | 0.691569 | 4 | 0 | 4 |
| TLE1 | MOB3A | 0.691158 | 3 | 0 | 3 |
| TLE1 | MYH7 | 0.689862 | 3 | 0 | 3 |
| TLE1 | CLMP | 0.688311 | 3 | 0 | 3 |
| TLE1 | TERF2IP | 0.687957 | 4 | 0 | 4 |
| TLE1 | FIGN | 0.687054 | 3 | 0 | 3 |
| TLE1 | VSTM4 | 0.68525 | 3 | 0 | 3 |
| TLE1 | FUNDC2 | 0.679231 | 3 | 0 | 3 |
| TLE1 | CD93 | 0.678948 | 3 | 0 | 3 |
For details and further investigation, click here
