| Full name: myosin heavy chain 7 | Alias Symbol: CMD1S | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 4625 | HGNC ID: HGNC:7577 | Ensembl Gene: ENSG00000092054 | OMIM ID: 160760 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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MYH7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04530 | Tight junction |
Expression of MYH7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYH7 | 4625 | 216265_x_at | -0.0064 | 0.9857 | |
| GSE20347 | MYH7 | 4625 | 216265_x_at | 0.0397 | 0.5218 | |
| GSE23400 | MYH7 | 4625 | 216265_x_at | -0.1124 | 0.0000 | |
| GSE26886 | MYH7 | 4625 | 216265_x_at | 0.1116 | 0.3804 | |
| GSE29001 | MYH7 | 4625 | 216265_x_at | -0.0800 | 0.5001 | |
| GSE38129 | MYH7 | 4625 | 216265_x_at | -0.0131 | 0.8236 | |
| GSE45670 | MYH7 | 4625 | 216265_x_at | 0.0435 | 0.7278 | |
| GSE53622 | MYH7 | 4625 | 148324 | -0.3189 | 0.0000 | |
| GSE53624 | MYH7 | 4625 | 148324 | -0.4395 | 0.0000 | |
| GSE63941 | MYH7 | 4625 | 216265_x_at | -0.1564 | 0.3589 | |
| GSE77861 | MYH7 | 4625 | 216265_x_at | 0.0383 | 0.6910 | |
| GSE97050 | MYH7 | 4625 | A_33_P3266964 | -1.4091 | 0.1218 | |
| TCGA | MYH7 | 4625 | RNAseq | 1.9647 | 0.1713 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYH7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYH7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYH7 | 4625 | 9 | 1 | 20 | |
| GSE20123 | MYH7 | 4625 | 8 | 1 | 21 | |
| GSE43470 | MYH7 | 4625 | 7 | 2 | 34 | |
| GSE46452 | MYH7 | 4625 | 17 | 2 | 40 | |
| GSE47630 | MYH7 | 4625 | 11 | 10 | 19 | |
| GSE54993 | MYH7 | 4625 | 3 | 11 | 56 | |
| GSE54994 | MYH7 | 4625 | 18 | 5 | 30 | |
| GSE60625 | MYH7 | 4625 | 0 | 2 | 9 | |
| GSE74703 | MYH7 | 4625 | 6 | 2 | 28 | |
| GSE74704 | MYH7 | 4625 | 3 | 1 | 16 | |
| TCGA | MYH7 | 4625 | 27 | 14 | 55 |
Total number of gains: 109; Total number of losses: 51; Total Number of normals: 328.
Somatic mutations of MYH7:
Generating mutation plots.
Highly correlated genes for MYH7:
Showing top 20/174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYH7 | NELL1 | 0.743079 | 3 | 0 | 3 |
| MYH7 | STAC | 0.715534 | 3 | 0 | 3 |
| MYH7 | LACTBL1 | 0.699256 | 3 | 0 | 3 |
| MYH7 | NT5M | 0.695083 | 3 | 0 | 3 |
| MYH7 | SGCA | 0.69308 | 3 | 0 | 3 |
| MYH7 | AKAP7 | 0.692116 | 3 | 0 | 3 |
| MYH7 | CITED1 | 0.69115 | 3 | 0 | 3 |
| MYH7 | TLE1 | 0.689862 | 3 | 0 | 3 |
| MYH7 | ABCA6 | 0.688395 | 3 | 0 | 3 |
| MYH7 | RNF224 | 0.68113 | 3 | 0 | 3 |
| MYH7 | NKX6-1 | 0.675922 | 3 | 0 | 3 |
| MYH7 | ANGPTL7 | 0.667913 | 3 | 0 | 3 |
| MYH7 | LAMC3 | 0.665381 | 3 | 0 | 3 |
| MYH7 | RFTN2 | 0.661896 | 3 | 0 | 3 |
| MYH7 | LSM11 | 0.656591 | 3 | 0 | 3 |
| MYH7 | SYNE1 | 0.655489 | 3 | 0 | 3 |
| MYH7 | FZR1 | 0.652442 | 3 | 0 | 3 |
| MYH7 | ST8SIA5 | 0.651542 | 4 | 0 | 3 |
| MYH7 | SYDE1 | 0.647964 | 4 | 0 | 4 |
| MYH7 | RAPGEF1 | 0.645871 | 4 | 0 | 4 |
For details and further investigation, click here
