| Full name: TLE family member 6, subcortical maternal complex member | Alias Symbol: FLJ14009|GRG6 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 79816 | HGNC ID: HGNC:30788 | Ensembl Gene: ENSG00000104953 | OMIM ID: 612399 |
| Drug and gene relationship at DGIdb | |||
Expression of TLE6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLE6 | 79816 | 222219_s_at | -0.0304 | 0.9204 | |
| GSE20347 | TLE6 | 79816 | 222219_s_at | -0.0344 | 0.7271 | |
| GSE23400 | TLE6 | 79816 | 222219_s_at | -0.0798 | 0.0207 | |
| GSE26886 | TLE6 | 79816 | 222219_s_at | 0.1285 | 0.3188 | |
| GSE29001 | TLE6 | 79816 | 222219_s_at | -0.1113 | 0.3875 | |
| GSE38129 | TLE6 | 79816 | 222219_s_at | -0.0284 | 0.8184 | |
| GSE45670 | TLE6 | 79816 | 222219_s_at | 0.0005 | 0.9972 | |
| GSE53622 | TLE6 | 79816 | 29044 | 0.2871 | 0.0014 | |
| GSE53624 | TLE6 | 79816 | 29044 | 0.2544 | 0.0002 | |
| GSE63941 | TLE6 | 79816 | 222219_s_at | 0.4005 | 0.0360 | |
| GSE77861 | TLE6 | 79816 | 222219_s_at | -0.0007 | 0.9972 | |
| GSE97050 | TLE6 | 79816 | A_23_P208937 | 0.2736 | 0.2992 | |
| SRP159526 | TLE6 | 79816 | RNAseq | 0.7184 | 0.1216 | |
| SRP219564 | TLE6 | 79816 | RNAseq | 1.1259 | 0.0481 | |
| TCGA | TLE6 | 79816 | RNAseq | 0.2176 | 0.6852 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TLE6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLE6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLE6 | 79816 | 4 | 4 | 22 | |
| GSE20123 | TLE6 | 79816 | 3 | 4 | 23 | |
| GSE43470 | TLE6 | 79816 | 1 | 9 | 33 | |
| GSE46452 | TLE6 | 79816 | 47 | 1 | 11 | |
| GSE47630 | TLE6 | 79816 | 5 | 7 | 28 | |
| GSE54993 | TLE6 | 79816 | 16 | 3 | 51 | |
| GSE54994 | TLE6 | 79816 | 8 | 16 | 29 | |
| GSE60625 | TLE6 | 79816 | 9 | 0 | 2 | |
| GSE74703 | TLE6 | 79816 | 1 | 6 | 29 | |
| GSE74704 | TLE6 | 79816 | 1 | 3 | 16 | |
| TCGA | TLE6 | 79816 | 8 | 22 | 66 |
Total number of gains: 103; Total number of losses: 75; Total Number of normals: 310.
Somatic mutations of TLE6:
Generating mutation plots.
Highly correlated genes for TLE6:
Showing top 20/694 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLE6 | OSBPL5 | 0.753891 | 3 | 0 | 3 |
| TLE6 | DEFB123 | 0.737365 | 3 | 0 | 3 |
| TLE6 | FMR1NB | 0.700226 | 4 | 0 | 4 |
| TLE6 | MFSD6L | 0.695182 | 3 | 0 | 3 |
| TLE6 | RAX | 0.694688 | 4 | 0 | 4 |
| TLE6 | SEC14L4 | 0.691911 | 5 | 0 | 5 |
| TLE6 | KCP | 0.676542 | 4 | 0 | 4 |
| TLE6 | MGAT5B | 0.674133 | 4 | 0 | 4 |
| TLE6 | DUOXA2 | 0.673906 | 4 | 0 | 3 |
| TLE6 | GPR150 | 0.672299 | 3 | 0 | 3 |
| TLE6 | COL20A1 | 0.666493 | 4 | 0 | 3 |
| TLE6 | CLTCL1 | 0.665916 | 4 | 0 | 4 |
| TLE6 | CALHM3 | 0.664663 | 3 | 0 | 3 |
| TLE6 | AMN | 0.662877 | 8 | 0 | 8 |
| TLE6 | DUSP9 | 0.662825 | 3 | 0 | 3 |
| TLE6 | WDR60 | 0.65512 | 3 | 0 | 3 |
| TLE6 | ANKFN1 | 0.653144 | 4 | 0 | 3 |
| TLE6 | FAM71F1 | 0.652142 | 4 | 0 | 3 |
| TLE6 | HGD | 0.649196 | 7 | 0 | 6 |
| TLE6 | TNP1 | 0.644361 | 5 | 0 | 4 |
For details and further investigation, click here
