| Full name: defensin beta 123 | Alias Symbol: DEFB-23 | ||
| Type: protein-coding gene | Cytoband: 20q11.21 | ||
| Entrez ID: 245936 | HGNC ID: HGNC:18103 | Ensembl Gene: ENSG00000180424 | OMIM ID: 616076 |
| Drug and gene relationship at DGIdb | |||
Expression of DEFB123:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFB123 | 245936 | 229772_at | 0.0713 | 0.8004 | |
| GSE26886 | DEFB123 | 245936 | 229772_at | 0.0421 | 0.6930 | |
| GSE45670 | DEFB123 | 245936 | 229772_at | 0.0900 | 0.4525 | |
| GSE53622 | DEFB123 | 245936 | 92477 | 0.3308 | 0.0235 | |
| GSE53624 | DEFB123 | 245936 | 92477 | 0.0623 | 0.5919 | |
| GSE63941 | DEFB123 | 245936 | 229772_at | 0.0522 | 0.7553 | |
| GSE77861 | DEFB123 | 245936 | 229772_at | -0.0445 | 0.7377 | |
| GSE97050 | DEFB123 | 245936 | A_23_P356694 | 0.1201 | 0.5321 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFB123 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEFB123:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFB123 | 245936 | 14 | 0 | 16 | |
| GSE20123 | DEFB123 | 245936 | 14 | 0 | 16 | |
| GSE43470 | DEFB123 | 245936 | 11 | 0 | 32 | |
| GSE46452 | DEFB123 | 245936 | 29 | 0 | 30 | |
| GSE47630 | DEFB123 | 245936 | 24 | 0 | 16 | |
| GSE54993 | DEFB123 | 245936 | 0 | 17 | 53 | |
| GSE54994 | DEFB123 | 245936 | 27 | 1 | 25 | |
| GSE60625 | DEFB123 | 245936 | 0 | 0 | 11 | |
| GSE74703 | DEFB123 | 245936 | 10 | 0 | 26 | |
| GSE74704 | DEFB123 | 245936 | 9 | 0 | 11 | |
| TCGA | DEFB123 | 245936 | 49 | 1 | 46 |
Total number of gains: 187; Total number of losses: 19; Total Number of normals: 282.
Somatic mutations of DEFB123:
Generating mutation plots.
Highly correlated genes for DEFB123:
Showing top 20/176 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFB123 | STRC | 0.762762 | 3 | 0 | 3 |
| DEFB123 | OR2C3 | 0.739324 | 4 | 0 | 4 |
| DEFB123 | MEGF10 | 0.738668 | 3 | 0 | 3 |
| DEFB123 | TLE6 | 0.737365 | 3 | 0 | 3 |
| DEFB123 | CALCA | 0.727151 | 3 | 0 | 3 |
| DEFB123 | OR4D6 | 0.725972 | 3 | 0 | 3 |
| DEFB123 | CIB3 | 0.706632 | 3 | 0 | 3 |
| DEFB123 | CNPY1 | 0.702132 | 5 | 0 | 4 |
| DEFB123 | CCNJL | 0.699448 | 3 | 0 | 3 |
| DEFB123 | LRTM1 | 0.699373 | 3 | 0 | 3 |
| DEFB123 | HOXD9 | 0.69709 | 3 | 0 | 3 |
| DEFB123 | CTSE | 0.694335 | 3 | 0 | 3 |
| DEFB123 | RAX2 | 0.690352 | 3 | 0 | 3 |
| DEFB123 | PNLIPRP1 | 0.689247 | 4 | 0 | 4 |
| DEFB123 | GRIK4 | 0.680244 | 4 | 0 | 3 |
| DEFB123 | LELP1 | 0.67991 | 3 | 0 | 3 |
| DEFB123 | DCDC1 | 0.679098 | 3 | 0 | 3 |
| DEFB123 | ASGR2 | 0.67775 | 3 | 0 | 3 |
| DEFB123 | GRID2 | 0.667706 | 3 | 0 | 3 |
| DEFB123 | ATP2B2 | 0.6677 | 3 | 0 | 3 |
For details and further investigation, click here
