| Full name: transmembrane 7 superfamily member 2 | Alias Symbol: ANG1|DHCR14A|NET47 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 7108 | HGNC ID: HGNC:11863 | Ensembl Gene: ENSG00000149809 | OMIM ID: 603414 |
| Drug and gene relationship at DGIdb | |||
Expression of TM7SF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TM7SF2 | 7108 | 210130_s_at | -0.6132 | 0.4067 | |
| GSE20347 | TM7SF2 | 7108 | 210130_s_at | -1.5676 | 0.0000 | |
| GSE23400 | TM7SF2 | 7108 | 210130_s_at | -1.0720 | 0.0000 | |
| GSE26886 | TM7SF2 | 7108 | 210130_s_at | -2.4646 | 0.0000 | |
| GSE29001 | TM7SF2 | 7108 | 210130_s_at | -1.8317 | 0.0000 | |
| GSE38129 | TM7SF2 | 7108 | 210130_s_at | -1.2458 | 0.0000 | |
| GSE45670 | TM7SF2 | 7108 | 210130_s_at | -0.3239 | 0.3110 | |
| GSE53622 | TM7SF2 | 7108 | 60815 | -1.6625 | 0.0000 | |
| GSE53624 | TM7SF2 | 7108 | 60815 | -2.0095 | 0.0000 | |
| GSE63941 | TM7SF2 | 7108 | 210130_s_at | 2.7829 | 0.0075 | |
| GSE77861 | TM7SF2 | 7108 | 210130_s_at | -0.8266 | 0.0138 | |
| GSE97050 | TM7SF2 | 7108 | A_23_P116037 | -0.4808 | 0.1791 | |
| SRP007169 | TM7SF2 | 7108 | RNAseq | -3.2949 | 0.0000 | |
| SRP008496 | TM7SF2 | 7108 | RNAseq | -2.8224 | 0.0000 | |
| SRP064894 | TM7SF2 | 7108 | RNAseq | -1.5836 | 0.0000 | |
| SRP133303 | TM7SF2 | 7108 | RNAseq | -1.7143 | 0.0001 | |
| SRP159526 | TM7SF2 | 7108 | RNAseq | -1.3153 | 0.0006 | |
| SRP193095 | TM7SF2 | 7108 | RNAseq | -1.7700 | 0.0000 | |
| SRP219564 | TM7SF2 | 7108 | RNAseq | -2.5053 | 0.0000 | |
| TCGA | TM7SF2 | 7108 | RNAseq | -0.5708 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 14.
Survival by TM7SF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TM7SF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TM7SF2 | 7108 | 7 | 6 | 17 | |
| GSE20123 | TM7SF2 | 7108 | 7 | 6 | 17 | |
| GSE43470 | TM7SF2 | 7108 | 2 | 3 | 38 | |
| GSE46452 | TM7SF2 | 7108 | 11 | 3 | 45 | |
| GSE47630 | TM7SF2 | 7108 | 5 | 6 | 29 | |
| GSE54993 | TM7SF2 | 7108 | 3 | 0 | 67 | |
| GSE54994 | TM7SF2 | 7108 | 6 | 5 | 42 | |
| GSE60625 | TM7SF2 | 7108 | 0 | 3 | 8 | |
| GSE74703 | TM7SF2 | 7108 | 2 | 1 | 33 | |
| GSE74704 | TM7SF2 | 7108 | 5 | 4 | 11 | |
| TCGA | TM7SF2 | 7108 | 23 | 7 | 66 |
Total number of gains: 71; Total number of losses: 44; Total Number of normals: 373.
Somatic mutations of TM7SF2:
Generating mutation plots.
Highly correlated genes for TM7SF2:
Showing top 20/1477 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TM7SF2 | ANXA9 | 0.825296 | 11 | 0 | 11 |
| TM7SF2 | SLURP1 | 0.815583 | 10 | 0 | 10 |
| TM7SF2 | ENDOU | 0.810284 | 11 | 0 | 11 |
| TM7SF2 | MPZL3 | 0.806961 | 8 | 0 | 8 |
| TM7SF2 | TOM1 | 0.805951 | 11 | 0 | 11 |
| TM7SF2 | GLTP | 0.803014 | 9 | 0 | 9 |
| TM7SF2 | ZDHHC13 | 0.798194 | 11 | 0 | 11 |
| TM7SF2 | CEACAM7 | 0.796958 | 10 | 0 | 10 |
| TM7SF2 | SULT2B1 | 0.795852 | 9 | 0 | 9 |
| TM7SF2 | EPS8L2 | 0.795529 | 10 | 0 | 10 |
| TM7SF2 | TTC9 | 0.794015 | 12 | 0 | 11 |
| TM7SF2 | ULK3 | 0.791238 | 8 | 0 | 7 |
| TM7SF2 | PCBP1-AS1 | 0.784654 | 3 | 0 | 3 |
| TM7SF2 | PRSS2 | 0.783343 | 8 | 0 | 8 |
| TM7SF2 | CWH43 | 0.781162 | 9 | 0 | 9 |
| TM7SF2 | USP6NL | 0.781131 | 11 | 0 | 11 |
| TM7SF2 | RANBP9 | 0.779046 | 11 | 0 | 11 |
| TM7SF2 | NLRX1 | 0.777712 | 11 | 0 | 11 |
| TM7SF2 | PRSS3 | 0.777587 | 11 | 0 | 11 |
| TM7SF2 | VSIG10L | 0.777287 | 6 | 0 | 6 |
For details and further investigation, click here
