| Full name: serine protease 3 | Alias Symbol: TRY3|TRY4 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 5646 | HGNC ID: HGNC:9486 | Ensembl Gene: ENSG00000010438 | OMIM ID: 613578 |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRSS3 | 5646 | 213421_x_at | -2.0276 | 0.2197 | |
| GSE20347 | PRSS3 | 5646 | 213421_x_at | -2.5486 | 0.0000 | |
| GSE23400 | PRSS3 | 5646 | 213421_x_at | -2.4453 | 0.0000 | |
| GSE26886 | PRSS3 | 5646 | 213421_x_at | -3.5280 | 0.0000 | |
| GSE29001 | PRSS3 | 5646 | 213421_x_at | -3.0680 | 0.0000 | |
| GSE38129 | PRSS3 | 5646 | 213421_x_at | -2.1057 | 0.0000 | |
| GSE45670 | PRSS3 | 5646 | 213421_x_at | -0.9740 | 0.1421 | |
| GSE53622 | PRSS3 | 5646 | 15159 | -2.8482 | 0.0000 | |
| GSE53624 | PRSS3 | 5646 | 15159 | -3.3441 | 0.0000 | |
| GSE63941 | PRSS3 | 5646 | 213421_x_at | -0.2128 | 0.8655 | |
| GSE77861 | PRSS3 | 5646 | 213421_x_at | -1.8048 | 0.0046 | |
| GSE97050 | PRSS3 | 5646 | A_23_P135257 | 0.2036 | 0.8277 | |
| SRP007169 | PRSS3 | 5646 | RNAseq | -4.8583 | 0.0000 | |
| SRP008496 | PRSS3 | 5646 | RNAseq | -4.1840 | 0.0000 | |
| SRP064894 | PRSS3 | 5646 | RNAseq | -3.6426 | 0.0000 | |
| SRP133303 | PRSS3 | 5646 | RNAseq | -3.3847 | 0.0000 | |
| SRP159526 | PRSS3 | 5646 | RNAseq | -4.3596 | 0.0000 | |
| SRP193095 | PRSS3 | 5646 | RNAseq | -3.3589 | 0.0000 | |
| TCGA | PRSS3 | 5646 | RNAseq | -0.6360 | 0.1786 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by PRSS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRSS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS3 | 5646 | 3 | 14 | 13 | |
| GSE20123 | PRSS3 | 5646 | 3 | 14 | 13 | |
| GSE43470 | PRSS3 | 5646 | 3 | 10 | 30 | |
| GSE46452 | PRSS3 | 5646 | 6 | 15 | 38 | |
| GSE47630 | PRSS3 | 5646 | 1 | 20 | 19 | |
| GSE54993 | PRSS3 | 5646 | 6 | 0 | 64 | |
| GSE54994 | PRSS3 | 5646 | 6 | 12 | 35 | |
| GSE60625 | PRSS3 | 5646 | 0 | 0 | 11 | |
| GSE74703 | PRSS3 | 5646 | 2 | 7 | 27 | |
| GSE74704 | PRSS3 | 5646 | 0 | 11 | 9 | |
| TCGA | PRSS3 | 5646 | 16 | 45 | 35 |
Total number of gains: 46; Total number of losses: 148; Total Number of normals: 294.
Somatic mutations of PRSS3:
Generating mutation plots.
Highly correlated genes for PRSS3:
Showing top 20/1724 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS3 | PRSS2 | 0.901122 | 11 | 0 | 11 |
| PRSS3 | CYSRT1 | 0.894128 | 6 | 0 | 6 |
| PRSS3 | TMPRSS11E | 0.881789 | 11 | 0 | 11 |
| PRSS3 | CLIC3 | 0.859627 | 10 | 0 | 10 |
| PRSS3 | PRSS1 | 0.855415 | 3 | 0 | 3 |
| PRSS3 | SCEL | 0.854908 | 12 | 0 | 12 |
| PRSS3 | KLK13 | 0.852553 | 12 | 0 | 12 |
| PRSS3 | GDPD3 | 0.851773 | 12 | 0 | 11 |
| PRSS3 | EPS8L1 | 0.850291 | 12 | 0 | 11 |
| PRSS3 | IL36A | 0.847904 | 11 | 0 | 11 |
| PRSS3 | HOPX | 0.846247 | 12 | 0 | 11 |
| PRSS3 | SLURP1 | 0.84461 | 12 | 0 | 11 |
| PRSS3 | CXCR2 | 0.8439 | 10 | 0 | 10 |
| PRSS3 | SPINK5 | 0.84272 | 12 | 0 | 12 |
| PRSS3 | PADI1 | 0.840803 | 8 | 0 | 8 |
| PRSS3 | PSCA | 0.840763 | 8 | 0 | 8 |
| PRSS3 | TMEM40 | 0.840632 | 12 | 0 | 11 |
| PRSS3 | TTC9 | 0.83867 | 11 | 0 | 11 |
| PRSS3 | ECM1 | 0.836595 | 12 | 0 | 12 |
| PRSS3 | GYS2 | 0.835896 | 10 | 0 | 10 |
For details and further investigation, click here
