| Full name: suppressor of IKBKE 1 | Alias Symbol: FLJ21168|SIKE | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 80143 | HGNC ID: HGNC:26119 | Ensembl Gene: ENSG00000052723 | OMIM ID: 611656 |
| Drug and gene relationship at DGIdb | |||
SIKE1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of SIKE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIKE1 | 80143 | 228026_at | 0.0603 | 0.9293 | |
| GSE20347 | SIKE1 | 80143 | 221705_s_at | -0.0017 | 0.9904 | |
| GSE23400 | SIKE1 | 80143 | 221705_s_at | -0.0981 | 0.0428 | |
| GSE26886 | SIKE1 | 80143 | 228026_at | -0.4454 | 0.0852 | |
| GSE29001 | SIKE1 | 80143 | 221705_s_at | 0.2692 | 0.5519 | |
| GSE38129 | SIKE1 | 80143 | 221705_s_at | 0.0670 | 0.5742 | |
| GSE45670 | SIKE1 | 80143 | 228026_at | 0.0466 | 0.7956 | |
| GSE53622 | SIKE1 | 80143 | 101848 | 0.1026 | 0.1238 | |
| GSE53624 | SIKE1 | 80143 | 6956 | 0.2395 | 0.0022 | |
| GSE63941 | SIKE1 | 80143 | 228026_at | -0.8331 | 0.1831 | |
| GSE77861 | SIKE1 | 80143 | 228026_at | -0.0551 | 0.9144 | |
| GSE97050 | SIKE1 | 80143 | A_33_P3383261 | -0.0206 | 0.9347 | |
| SRP007169 | SIKE1 | 80143 | RNAseq | 0.2072 | 0.5824 | |
| SRP008496 | SIKE1 | 80143 | RNAseq | -0.0983 | 0.6661 | |
| SRP064894 | SIKE1 | 80143 | RNAseq | 0.1048 | 0.5107 | |
| SRP133303 | SIKE1 | 80143 | RNAseq | 0.3102 | 0.0233 | |
| SRP159526 | SIKE1 | 80143 | RNAseq | -0.1680 | 0.6490 | |
| SRP193095 | SIKE1 | 80143 | RNAseq | -0.1138 | 0.2635 | |
| SRP219564 | SIKE1 | 80143 | RNAseq | -0.0422 | 0.9070 | |
| TCGA | SIKE1 | 80143 | RNAseq | 0.0345 | 0.4991 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIKE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIKE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIKE1 | 80143 | 0 | 9 | 21 | |
| GSE20123 | SIKE1 | 80143 | 0 | 9 | 21 | |
| GSE43470 | SIKE1 | 80143 | 0 | 8 | 35 | |
| GSE46452 | SIKE1 | 80143 | 2 | 1 | 56 | |
| GSE47630 | SIKE1 | 80143 | 9 | 5 | 26 | |
| GSE54993 | SIKE1 | 80143 | 0 | 1 | 69 | |
| GSE54994 | SIKE1 | 80143 | 7 | 3 | 43 | |
| GSE60625 | SIKE1 | 80143 | 0 | 0 | 11 | |
| GSE74703 | SIKE1 | 80143 | 0 | 7 | 29 | |
| GSE74704 | SIKE1 | 80143 | 0 | 5 | 15 | |
| TCGA | SIKE1 | 80143 | 13 | 29 | 54 |
Total number of gains: 31; Total number of losses: 77; Total Number of normals: 380.
Somatic mutations of SIKE1:
Generating mutation plots.
Highly correlated genes for SIKE1:
Showing top 20/199 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIKE1 | IREB2 | 0.779822 | 3 | 0 | 3 |
| SIKE1 | TRUB1 | 0.779181 | 3 | 0 | 3 |
| SIKE1 | PALB2 | 0.767926 | 3 | 0 | 3 |
| SIKE1 | PYROXD1 | 0.756013 | 3 | 0 | 3 |
| SIKE1 | C21orf91 | 0.740091 | 3 | 0 | 3 |
| SIKE1 | FAS | 0.729875 | 3 | 0 | 3 |
| SIKE1 | ZNF217 | 0.727857 | 3 | 0 | 3 |
| SIKE1 | HGSNAT | 0.72598 | 4 | 0 | 4 |
| SIKE1 | TMED2 | 0.725505 | 3 | 0 | 3 |
| SIKE1 | ARL5B | 0.721567 | 4 | 0 | 3 |
| SIKE1 | UBE3C | 0.718435 | 4 | 0 | 3 |
| SIKE1 | SLC37A3 | 0.718154 | 3 | 0 | 3 |
| SIKE1 | C5orf24 | 0.713575 | 3 | 0 | 3 |
| SIKE1 | TAS2R19 | 0.710358 | 3 | 0 | 3 |
| SIKE1 | ANKRD13C | 0.709438 | 5 | 0 | 4 |
| SIKE1 | AHCYL2 | 0.709295 | 4 | 0 | 4 |
| SIKE1 | IL10RB | 0.707927 | 3 | 0 | 3 |
| SIKE1 | SGMS1 | 0.705534 | 4 | 0 | 3 |
| SIKE1 | RCN2 | 0.704212 | 3 | 0 | 3 |
| SIKE1 | RC3H1 | 0.703405 | 3 | 0 | 3 |
For details and further investigation, click here
