| Full name: adenosylhomocysteinase | Alias Symbol: SAHH | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 191 | HGNC ID: HGNC:343 | Ensembl Gene: ENSG00000101444 | OMIM ID: 180960 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AHCY:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AHCY | 191 | 200903_s_at | 0.6275 | 0.1651 | |
| GSE20347 | AHCY | 191 | 200903_s_at | 0.1577 | 0.4476 | |
| GSE23400 | AHCY | 191 | 200903_s_at | 0.0586 | 0.5840 | |
| GSE26886 | AHCY | 191 | 200903_s_at | -0.0486 | 0.8838 | |
| GSE29001 | AHCY | 191 | 200903_s_at | -0.5001 | 0.2074 | |
| GSE38129 | AHCY | 191 | 200903_s_at | 0.4765 | 0.0060 | |
| GSE45670 | AHCY | 191 | 200903_s_at | -0.1469 | 0.4508 | |
| GSE53622 | AHCY | 191 | 52642 | 0.0874 | 0.4886 | |
| GSE53624 | AHCY | 191 | 52642 | -0.1374 | 0.1347 | |
| GSE63941 | AHCY | 191 | 200903_s_at | 0.2457 | 0.6318 | |
| GSE77861 | AHCY | 191 | 200903_s_at | 0.3270 | 0.3721 | |
| GSE97050 | AHCY | 191 | A_24_P57367 | 0.2478 | 0.7130 | |
| SRP007169 | AHCY | 191 | RNAseq | -1.5667 | 0.0000 | |
| SRP008496 | AHCY | 191 | RNAseq | -1.1160 | 0.0000 | |
| SRP064894 | AHCY | 191 | RNAseq | -0.8041 | 0.0007 | |
| SRP133303 | AHCY | 191 | RNAseq | -0.1324 | 0.4032 | |
| SRP159526 | AHCY | 191 | RNAseq | -0.1120 | 0.6604 | |
| SRP193095 | AHCY | 191 | RNAseq | -0.5863 | 0.0008 | |
| SRP219564 | AHCY | 191 | RNAseq | -0.2069 | 0.6397 | |
| TCGA | AHCY | 191 | RNAseq | 0.1360 | 0.0052 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by AHCY expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AHCY:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AHCY | 191 | 16 | 0 | 14 | |
| GSE20123 | AHCY | 191 | 16 | 0 | 14 | |
| GSE43470 | AHCY | 191 | 12 | 0 | 31 | |
| GSE46452 | AHCY | 191 | 29 | 0 | 30 | |
| GSE47630 | AHCY | 191 | 24 | 1 | 15 | |
| GSE54993 | AHCY | 191 | 0 | 18 | 52 | |
| GSE54994 | AHCY | 191 | 25 | 1 | 27 | |
| GSE60625 | AHCY | 191 | 0 | 0 | 11 | |
| GSE74703 | AHCY | 191 | 11 | 0 | 25 | |
| GSE74704 | AHCY | 191 | 11 | 0 | 9 | |
| TCGA | AHCY | 191 | 51 | 1 | 44 |
Total number of gains: 195; Total number of losses: 21; Total Number of normals: 272.
Somatic mutations of AHCY:
Generating mutation plots.
Highly correlated genes for AHCY:
Showing top 20/548 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AHCY | PPIL1 | 0.841965 | 3 | 0 | 3 |
| AHCY | TMED2 | 0.77114 | 4 | 0 | 4 |
| AHCY | ALG1 | 0.760419 | 3 | 0 | 3 |
| AHCY | C8orf76 | 0.759426 | 3 | 0 | 3 |
| AHCY | MTHFD1 | 0.745573 | 4 | 0 | 3 |
| AHCY | YY1 | 0.738502 | 4 | 0 | 4 |
| AHCY | UTP3 | 0.737438 | 3 | 0 | 3 |
| AHCY | HUS1 | 0.721369 | 3 | 0 | 3 |
| AHCY | FAM110A | 0.719477 | 3 | 0 | 3 |
| AHCY | MRPL3 | 0.714025 | 5 | 0 | 4 |
| AHCY | PPP2R5E | 0.713481 | 4 | 0 | 3 |
| AHCY | TRAF7 | 0.713382 | 3 | 0 | 3 |
| AHCY | VPS28 | 0.712622 | 3 | 0 | 3 |
| AHCY | SIVA1 | 0.712213 | 4 | 0 | 3 |
| AHCY | EED | 0.711815 | 3 | 0 | 3 |
| AHCY | PRDM15 | 0.711592 | 3 | 0 | 3 |
| AHCY | LGALS8 | 0.706619 | 3 | 0 | 3 |
| AHCY | SEC61A1 | 0.704448 | 4 | 0 | 3 |
| AHCY | LANCL2 | 0.701123 | 5 | 0 | 5 |
| AHCY | HJURP | 0.699179 | 4 | 0 | 4 |
For details and further investigation, click here
