| Full name: partner and localizer of BRCA2 | Alias Symbol: FLJ21816|FANCN | ||
| Type: protein-coding gene | Cytoband: 16p12.2 | ||
| Entrez ID: 79728 | HGNC ID: HGNC:26144 | Ensembl Gene: ENSG00000083093 | OMIM ID: 610355 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PALB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of PALB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PALB2 | 79728 | 219530_at | 0.4395 | 0.4992 | |
| GSE20347 | PALB2 | 79728 | 219530_at | 0.3477 | 0.0001 | |
| GSE23400 | PALB2 | 79728 | 219530_at | 0.5537 | 0.0000 | |
| GSE26886 | PALB2 | 79728 | 219530_at | -0.4167 | 0.0804 | |
| GSE29001 | PALB2 | 79728 | 219530_at | 0.4928 | 0.0061 | |
| GSE38129 | PALB2 | 79728 | 219530_at | 0.5364 | 0.0000 | |
| GSE45670 | PALB2 | 79728 | 219530_at | 0.3828 | 0.0001 | |
| GSE53622 | PALB2 | 79728 | 148374 | 0.4035 | 0.0000 | |
| GSE53624 | PALB2 | 79728 | 148374 | 0.4465 | 0.0000 | |
| GSE63941 | PALB2 | 79728 | 219530_at | 0.0959 | 0.7442 | |
| GSE77861 | PALB2 | 79728 | 219530_at | 0.3871 | 0.1617 | |
| GSE97050 | PALB2 | 79728 | A_23_P129569 | 0.2707 | 0.3618 | |
| SRP007169 | PALB2 | 79728 | RNAseq | 0.7795 | 0.0876 | |
| SRP008496 | PALB2 | 79728 | RNAseq | 0.6839 | 0.0100 | |
| SRP064894 | PALB2 | 79728 | RNAseq | 0.1575 | 0.5150 | |
| SRP133303 | PALB2 | 79728 | RNAseq | 0.5929 | 0.0005 | |
| SRP159526 | PALB2 | 79728 | RNAseq | 0.3718 | 0.0651 | |
| SRP193095 | PALB2 | 79728 | RNAseq | 0.3446 | 0.0022 | |
| SRP219564 | PALB2 | 79728 | RNAseq | 0.1973 | 0.6306 | |
| TCGA | PALB2 | 79728 | RNAseq | 0.3760 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PALB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PALB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PALB2 | 79728 | 6 | 4 | 20 | |
| GSE20123 | PALB2 | 79728 | 6 | 3 | 21 | |
| GSE43470 | PALB2 | 79728 | 3 | 3 | 37 | |
| GSE46452 | PALB2 | 79728 | 38 | 1 | 20 | |
| GSE47630 | PALB2 | 79728 | 11 | 6 | 23 | |
| GSE54993 | PALB2 | 79728 | 3 | 5 | 62 | |
| GSE54994 | PALB2 | 79728 | 4 | 8 | 41 | |
| GSE60625 | PALB2 | 79728 | 4 | 0 | 7 | |
| GSE74703 | PALB2 | 79728 | 3 | 2 | 31 | |
| GSE74704 | PALB2 | 79728 | 3 | 1 | 16 | |
| TCGA | PALB2 | 79728 | 19 | 14 | 63 |
Total number of gains: 100; Total number of losses: 47; Total Number of normals: 341.
Somatic mutations of PALB2:
Generating mutation plots.
Highly correlated genes for PALB2:
Showing top 20/1184 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PALB2 | TRAF7 | 0.863574 | 4 | 0 | 4 |
| PALB2 | TMED2 | 0.807376 | 3 | 0 | 3 |
| PALB2 | PLEKHM3 | 0.793556 | 3 | 0 | 3 |
| PALB2 | SFT2D3 | 0.790115 | 3 | 0 | 3 |
| PALB2 | ALG10 | 0.770683 | 4 | 0 | 4 |
| PALB2 | SIKE1 | 0.767926 | 3 | 0 | 3 |
| PALB2 | USP38 | 0.766385 | 3 | 0 | 3 |
| PALB2 | DUSP18 | 0.764666 | 3 | 0 | 3 |
| PALB2 | SLC37A3 | 0.756371 | 3 | 0 | 3 |
| PALB2 | DDX20 | 0.754062 | 3 | 0 | 3 |
| PALB2 | FBXL19 | 0.752827 | 3 | 0 | 3 |
| PALB2 | VCPIP1 | 0.752433 | 3 | 0 | 3 |
| PALB2 | GK5 | 0.747538 | 3 | 0 | 3 |
| PALB2 | MGMT | 0.741319 | 3 | 0 | 3 |
| PALB2 | WIPI1 | 0.737134 | 3 | 0 | 3 |
| PALB2 | MIS18BP1 | 0.737126 | 3 | 0 | 3 |
| PALB2 | CCDC126 | 0.733601 | 3 | 0 | 3 |
| PALB2 | SND1 | 0.733488 | 3 | 0 | 3 |
| PALB2 | RAD18 | 0.72741 | 3 | 0 | 3 |
| PALB2 | PRPF38A | 0.726441 | 3 | 0 | 3 |
For details and further investigation, click here
