TMED9

 

Full name: transmembrane p24 trafficking protein 9 Alias Symbol: HSGP25L2G|p24alpha2|p24a2
Type: protein-coding gene Cytoband: 5q35.3
Entrez ID: 54732 HGNC ID: HGNC:24878 Ensembl Gene: ENSG00000184840 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TMED9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMED9 54732 208757_at 0.1912 0.6923
GSE20347 TMED9 54732 208757_at -0.3232 0.0010
GSE23400 TMED9 54732 208757_at -0.0021 0.9723
GSE26886 TMED9 54732 208757_at -0.1456 0.1455
GSE29001 TMED9 54732 208757_at -0.2980 0.1440
GSE38129 TMED9 54732 208757_at 0.0315 0.8596
GSE45670 TMED9 54732 208757_at 0.0959 0.5163
GSE53622 TMED9 54732 3965 -0.0591 0.4234
GSE53624 TMED9 54732 3965 0.1020 0.0495
GSE63941 TMED9 54732 208757_at -0.5041 0.1928
GSE77861 TMED9 54732 208757_at -0.0416 0.8707
GSE97050 TMED9 54732 A_23_P70127 0.6624 0.1592
SRP007169 TMED9 54732 RNAseq -0.9854 0.0066
SRP008496 TMED9 54732 RNAseq -0.9126 0.0001
SRP064894 TMED9 54732 RNAseq 0.3064 0.2020
SRP133303 TMED9 54732 RNAseq 0.3022 0.1585
SRP159526 TMED9 54732 RNAseq -0.0035 0.9907
SRP193095 TMED9 54732 RNAseq -0.2600 0.0552
SRP219564 TMED9 54732 RNAseq 0.3731 0.2807
TCGA TMED9 54732 RNAseq 0.0353 0.4546

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TMED9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TMED9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMED9 54732 2 13 15
GSE20123 TMED9 54732 2 13 15
GSE43470 TMED9 54732 1 11 31
GSE46452 TMED9 54732 0 27 32
GSE47630 TMED9 54732 1 20 19
GSE54993 TMED9 54732 10 2 58
GSE54994 TMED9 54732 2 17 34
GSE60625 TMED9 54732 1 0 10
GSE74703 TMED9 54732 1 7 28
GSE74704 TMED9 54732 1 6 13
TCGA TMED9 54732 8 34 54

Total number of gains: 29; Total number of losses: 150; Total Number of normals: 309.  

 

Somatic mutations of TMED9:

 

Generating mutation plots.

 

Highly correlated genes for TMED9:

 

Showing top 20/307 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMED9B9D20.766687303
TMED9SUSD10.752257303
TMED9OLFM20.749788303
TMED9OSTC0.748185403
TMED9FAM110A0.736736303
TMED9TAF120.734665303
TMED9LASP10.725676303
TMED9SEC23B0.721376303
TMED9PRELID10.721318505
TMED9PLEKHA40.716971303
TMED9MCCC20.714332404
TMED9RNF1490.691008404
TMED9JKAMP0.687537303
TMED9ZNF7870.68659303
TMED9TOP3A0.683635303
TMED9ACVRL10.6788303
TMED9SARDH0.673964303
TMED9SYT70.672159303
TMED9KCTD100.671884404
TMED9DHODH0.671059303

For details and further investigation, click here