| Full name: SEC23 homolog B, coat complex II component | Alias Symbol: CDA-II|CDAII|HEMPAS | ||
| Type: protein-coding gene | Cytoband: 20p11.23 | ||
| Entrez ID: 10483 | HGNC ID: HGNC:10702 | Ensembl Gene: ENSG00000101310 | OMIM ID: 610512 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SEC23B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC23B | 10483 | 210293_s_at | 0.2957 | 0.7372 | |
| GSE20347 | SEC23B | 10483 | 210293_s_at | -0.3112 | 0.0115 | |
| GSE23400 | SEC23B | 10483 | 201583_s_at | -0.2670 | 0.0004 | |
| GSE26886 | SEC23B | 10483 | 210293_s_at | -0.3296 | 0.0514 | |
| GSE29001 | SEC23B | 10483 | 210293_s_at | -0.0889 | 0.6958 | |
| GSE38129 | SEC23B | 10483 | 210293_s_at | 0.0976 | 0.5606 | |
| GSE45670 | SEC23B | 10483 | 210293_s_at | 0.1881 | 0.2601 | |
| GSE53622 | SEC23B | 10483 | 125872 | 0.0852 | 0.3618 | |
| GSE53624 | SEC23B | 10483 | 125872 | -0.2676 | 0.0001 | |
| GSE63941 | SEC23B | 10483 | 210293_s_at | 0.5310 | 0.1280 | |
| GSE77861 | SEC23B | 10483 | 210293_s_at | -0.4194 | 0.0292 | |
| GSE97050 | SEC23B | 10483 | A_24_P690924 | 1.1409 | 0.0828 | |
| SRP007169 | SEC23B | 10483 | RNAseq | -1.0957 | 0.0011 | |
| SRP008496 | SEC23B | 10483 | RNAseq | -0.9709 | 0.0000 | |
| SRP064894 | SEC23B | 10483 | RNAseq | -0.2764 | 0.1626 | |
| SRP133303 | SEC23B | 10483 | RNAseq | -0.0104 | 0.9331 | |
| SRP159526 | SEC23B | 10483 | RNAseq | -0.0812 | 0.8117 | |
| SRP193095 | SEC23B | 10483 | RNAseq | -0.3896 | 0.0015 | |
| SRP219564 | SEC23B | 10483 | RNAseq | -0.1310 | 0.7749 | |
| TCGA | SEC23B | 10483 | RNAseq | -0.0792 | 0.0920 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SEC23B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC23B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC23B | 10483 | 12 | 2 | 16 | |
| GSE20123 | SEC23B | 10483 | 12 | 2 | 16 | |
| GSE43470 | SEC23B | 10483 | 11 | 1 | 31 | |
| GSE46452 | SEC23B | 10483 | 27 | 1 | 31 | |
| GSE47630 | SEC23B | 10483 | 17 | 4 | 19 | |
| GSE54993 | SEC23B | 10483 | 0 | 15 | 55 | |
| GSE54994 | SEC23B | 10483 | 26 | 2 | 25 | |
| GSE60625 | SEC23B | 10483 | 0 | 0 | 11 | |
| GSE74703 | SEC23B | 10483 | 8 | 1 | 27 | |
| GSE74704 | SEC23B | 10483 | 7 | 2 | 11 | |
| TCGA | SEC23B | 10483 | 44 | 10 | 42 |
Total number of gains: 164; Total number of losses: 40; Total Number of normals: 284.
Somatic mutations of SEC23B:
Generating mutation plots.
Highly correlated genes for SEC23B:
Showing top 20/391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC23B | TMED9 | 0.721376 | 3 | 0 | 3 |
| SEC23B | CDV3 | 0.709613 | 3 | 0 | 3 |
| SEC23B | PTBP3 | 0.703467 | 6 | 0 | 5 |
| SEC23B | GINS3 | 0.682893 | 4 | 0 | 3 |
| SEC23B | CD2 | 0.68214 | 3 | 0 | 3 |
| SEC23B | MAPK13 | 0.660641 | 6 | 0 | 5 |
| SEC23B | TMX1 | 0.657084 | 4 | 0 | 3 |
| SEC23B | FAM107B | 0.652031 | 3 | 0 | 3 |
| SEC23B | AP1S3 | 0.641155 | 5 | 0 | 4 |
| SEC23B | TXNDC17 | 0.639289 | 3 | 0 | 3 |
| SEC23B | BAIAP2L1 | 0.638237 | 5 | 0 | 3 |
| SEC23B | ZNF485 | 0.637987 | 4 | 0 | 3 |
| SEC23B | POLR3B | 0.629485 | 9 | 0 | 8 |
| SEC23B | TMEM144 | 0.628508 | 3 | 0 | 3 |
| SEC23B | FAM110A | 0.625017 | 6 | 0 | 4 |
| SEC23B | DSC3 | 0.624437 | 4 | 0 | 4 |
| SEC23B | EIF6 | 0.623869 | 8 | 0 | 7 |
| SEC23B | TIFA | 0.622457 | 4 | 0 | 3 |
| SEC23B | SORD | 0.620123 | 4 | 0 | 3 |
| SEC23B | SLC22A18 | 0.616499 | 4 | 0 | 4 |
For details and further investigation, click here
