| Full name: DNA topoisomerase III alpha | Alias Symbol: ZGRF7 | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 7156 | HGNC ID: HGNC:11992 | Ensembl Gene: ENSG00000177302 | OMIM ID: 601243 |
| Drug and gene relationship at DGIdb | |||
TOP3A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of TOP3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOP3A | 7156 | 204946_s_at | 0.3560 | 0.2751 | |
| GSE20347 | TOP3A | 7156 | 204946_s_at | 0.0268 | 0.8024 | |
| GSE23400 | TOP3A | 7156 | 204946_s_at | -0.1182 | 0.0255 | |
| GSE26886 | TOP3A | 7156 | 214299_at | 0.4241 | 0.0120 | |
| GSE29001 | TOP3A | 7156 | 214299_at | 0.6521 | 0.0465 | |
| GSE38129 | TOP3A | 7156 | 204946_s_at | 0.1793 | 0.0232 | |
| GSE45670 | TOP3A | 7156 | 204946_s_at | 0.5620 | 0.0000 | |
| GSE53622 | TOP3A | 7156 | 20989 | 0.4440 | 0.0000 | |
| GSE53624 | TOP3A | 7156 | 20989 | 0.6166 | 0.0000 | |
| GSE63941 | TOP3A | 7156 | 204946_s_at | 1.3064 | 0.0166 | |
| GSE77861 | TOP3A | 7156 | 214299_at | -0.0090 | 0.9439 | |
| GSE97050 | TOP3A | 7156 | A_23_P15829 | 0.1878 | 0.3962 | |
| SRP007169 | TOP3A | 7156 | RNAseq | 1.5556 | 0.0009 | |
| SRP008496 | TOP3A | 7156 | RNAseq | 1.5630 | 0.0000 | |
| SRP064894 | TOP3A | 7156 | RNAseq | 1.0036 | 0.0000 | |
| SRP133303 | TOP3A | 7156 | RNAseq | 0.4330 | 0.0000 | |
| SRP159526 | TOP3A | 7156 | RNAseq | 1.0266 | 0.0225 | |
| SRP193095 | TOP3A | 7156 | RNAseq | 0.4360 | 0.0000 | |
| SRP219564 | TOP3A | 7156 | RNAseq | 0.8770 | 0.0127 | |
| TCGA | TOP3A | 7156 | RNAseq | 0.1003 | 0.0674 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by TOP3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOP3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOP3A | 7156 | 3 | 3 | 24 | |
| GSE20123 | TOP3A | 7156 | 3 | 4 | 23 | |
| GSE43470 | TOP3A | 7156 | 1 | 5 | 37 | |
| GSE46452 | TOP3A | 7156 | 34 | 1 | 24 | |
| GSE47630 | TOP3A | 7156 | 7 | 1 | 32 | |
| GSE54993 | TOP3A | 7156 | 3 | 3 | 64 | |
| GSE54994 | TOP3A | 7156 | 6 | 6 | 41 | |
| GSE60625 | TOP3A | 7156 | 4 | 0 | 7 | |
| GSE74703 | TOP3A | 7156 | 1 | 2 | 33 | |
| GSE74704 | TOP3A | 7156 | 2 | 1 | 17 | |
| TCGA | TOP3A | 7156 | 20 | 22 | 54 |
Total number of gains: 84; Total number of losses: 48; Total Number of normals: 356.
Somatic mutations of TOP3A:
Generating mutation plots.
Highly correlated genes for TOP3A:
Showing top 20/780 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOP3A | ROMO1 | 0.797609 | 3 | 0 | 3 |
| TOP3A | VPS41 | 0.773832 | 3 | 0 | 3 |
| TOP3A | SPATA5 | 0.729412 | 4 | 0 | 4 |
| TOP3A | XPNPEP1 | 0.728414 | 4 | 0 | 3 |
| TOP3A | SLC29A1 | 0.714988 | 3 | 0 | 3 |
| TOP3A | ECSIT | 0.707648 | 3 | 0 | 3 |
| TOP3A | INTS9 | 0.705652 | 4 | 0 | 4 |
| TOP3A | CENPBD1 | 0.704563 | 3 | 0 | 3 |
| TOP3A | TRIM62 | 0.702283 | 5 | 0 | 5 |
| TOP3A | NAA38 | 0.700856 | 3 | 0 | 3 |
| TOP3A | MYCN | 0.700134 | 3 | 0 | 3 |
| TOP3A | IPP | 0.697042 | 3 | 0 | 3 |
| TOP3A | DOCK5 | 0.696709 | 4 | 0 | 3 |
| TOP3A | NENF | 0.696693 | 3 | 0 | 3 |
| TOP3A | SUGP2 | 0.692906 | 3 | 0 | 3 |
| TOP3A | FARS2 | 0.687789 | 4 | 0 | 3 |
| TOP3A | NF1 | 0.687289 | 3 | 0 | 3 |
| TOP3A | SLC25A44 | 0.685947 | 4 | 0 | 4 |
| TOP3A | CKLF | 0.685807 | 3 | 0 | 3 |
| TOP3A | TMED9 | 0.683635 | 3 | 0 | 3 |
For details and further investigation, click here
