| Full name: dihydroorotate dehydrogenase (quinone) | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q22.2 | ||
| Entrez ID: 1723 | HGNC ID: HGNC:2867 | Ensembl Gene: ENSG00000102967 | OMIM ID: 126064 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DHODH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHODH | 1723 | 213632_at | 0.7419 | 0.0805 | |
| GSE20347 | DHODH | 1723 | 213632_at | 0.2559 | 0.0055 | |
| GSE23400 | DHODH | 1723 | 213632_at | -0.0424 | 0.3636 | |
| GSE26886 | DHODH | 1723 | 213632_at | 0.2160 | 0.1181 | |
| GSE29001 | DHODH | 1723 | 213632_at | 0.3029 | 0.2073 | |
| GSE38129 | DHODH | 1723 | 213632_at | 0.2746 | 0.0013 | |
| GSE45670 | DHODH | 1723 | 213632_at | 0.2304 | 0.1030 | |
| GSE53622 | DHODH | 1723 | 74766 | 0.1790 | 0.0192 | |
| GSE53624 | DHODH | 1723 | 74766 | 0.6525 | 0.0000 | |
| GSE63941 | DHODH | 1723 | 213632_at | 0.6892 | 0.1458 | |
| GSE77861 | DHODH | 1723 | 213632_at | -0.0868 | 0.4304 | |
| GSE97050 | DHODH | 1723 | A_23_P15202 | 0.2927 | 0.2332 | |
| SRP007169 | DHODH | 1723 | RNAseq | 0.9664 | 0.0879 | |
| SRP008496 | DHODH | 1723 | RNAseq | 0.2440 | 0.4792 | |
| SRP064894 | DHODH | 1723 | RNAseq | 0.0175 | 0.8868 | |
| SRP133303 | DHODH | 1723 | RNAseq | 0.0752 | 0.6330 | |
| SRP159526 | DHODH | 1723 | RNAseq | 0.2232 | 0.3994 | |
| SRP193095 | DHODH | 1723 | RNAseq | 0.1556 | 0.1503 | |
| SRP219564 | DHODH | 1723 | RNAseq | 0.0238 | 0.9281 | |
| TCGA | DHODH | 1723 | RNAseq | 0.1905 | 0.0263 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DHODH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHODH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHODH | 1723 | 4 | 0 | 26 | |
| GSE20123 | DHODH | 1723 | 4 | 0 | 26 | |
| GSE43470 | DHODH | 1723 | 2 | 8 | 33 | |
| GSE46452 | DHODH | 1723 | 38 | 2 | 19 | |
| GSE47630 | DHODH | 1723 | 11 | 8 | 21 | |
| GSE54993 | DHODH | 1723 | 2 | 4 | 64 | |
| GSE54994 | DHODH | 1723 | 8 | 10 | 35 | |
| GSE60625 | DHODH | 1723 | 4 | 0 | 7 | |
| GSE74703 | DHODH | 1723 | 2 | 5 | 29 | |
| GSE74704 | DHODH | 1723 | 2 | 0 | 18 | |
| TCGA | DHODH | 1723 | 27 | 13 | 56 |
Total number of gains: 104; Total number of losses: 50; Total Number of normals: 334.
Somatic mutations of DHODH:
Generating mutation plots.
Highly correlated genes for DHODH:
Showing top 20/525 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHODH | RNF2 | 0.780352 | 3 | 0 | 3 |
| DHODH | LINC00328 | 0.764074 | 3 | 0 | 3 |
| DHODH | HELB | 0.75769 | 3 | 0 | 3 |
| DHODH | HSDL1 | 0.748895 | 3 | 0 | 3 |
| DHODH | DNTTIP1 | 0.735994 | 4 | 0 | 4 |
| DHODH | LMBR1 | 0.724661 | 3 | 0 | 3 |
| DHODH | PDE7A | 0.716191 | 3 | 0 | 3 |
| DHODH | HSPB11 | 0.714238 | 3 | 0 | 3 |
| DHODH | UTP23 | 0.708355 | 3 | 0 | 3 |
| DHODH | ZNF90 | 0.706326 | 3 | 0 | 3 |
| DHODH | MED10 | 0.705619 | 3 | 0 | 3 |
| DHODH | PDRG1 | 0.697054 | 4 | 0 | 3 |
| DHODH | IL18RAP | 0.696584 | 3 | 0 | 3 |
| DHODH | ARL13B | 0.695608 | 3 | 0 | 3 |
| DHODH | NUDT4 | 0.692724 | 4 | 0 | 3 |
| DHODH | ATRIP | 0.690939 | 3 | 0 | 3 |
| DHODH | RAB11FIP3 | 0.684368 | 3 | 0 | 3 |
| DHODH | DNAJC19 | 0.681313 | 3 | 0 | 3 |
| DHODH | ROMO1 | 0.680059 | 4 | 0 | 3 |
| DHODH | ELP2 | 0.676925 | 4 | 0 | 3 |
For details and further investigation, click here
