| Full name: LIM and SH3 protein 1 | Alias Symbol: MLN50|Lasp-1 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 3927 | HGNC ID: HGNC:6513 | Ensembl Gene: ENSG00000002834 | OMIM ID: 602920 |
| Drug and gene relationship at DGIdb | |||
Expression of LASP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LASP1 | 3927 | 200618_at | 0.6751 | 0.1071 | |
| GSE20347 | LASP1 | 3927 | 200618_at | 0.3609 | 0.0055 | |
| GSE23400 | LASP1 | 3927 | 200618_at | 0.4366 | 0.0000 | |
| GSE26886 | LASP1 | 3927 | 200618_at | -0.0308 | 0.8838 | |
| GSE29001 | LASP1 | 3927 | 200618_at | 0.0735 | 0.7037 | |
| GSE38129 | LASP1 | 3927 | 200618_at | 0.3718 | 0.0006 | |
| GSE45670 | LASP1 | 3927 | 200618_at | 0.3062 | 0.0305 | |
| GSE53622 | LASP1 | 3927 | 86612 | 0.6891 | 0.0000 | |
| GSE53624 | LASP1 | 3927 | 86612 | 0.6820 | 0.0000 | |
| GSE63941 | LASP1 | 3927 | 200618_at | -0.3644 | 0.4535 | |
| GSE77861 | LASP1 | 3927 | 200618_at | 0.1439 | 0.5548 | |
| GSE97050 | LASP1 | 3927 | A_23_P89187 | 0.5404 | 0.1887 | |
| SRP007169 | LASP1 | 3927 | RNAseq | 0.6287 | 0.0983 | |
| SRP008496 | LASP1 | 3927 | RNAseq | 0.3279 | 0.1213 | |
| SRP064894 | LASP1 | 3927 | RNAseq | 0.6899 | 0.0000 | |
| SRP133303 | LASP1 | 3927 | RNAseq | 0.4787 | 0.0052 | |
| SRP159526 | LASP1 | 3927 | RNAseq | 0.0739 | 0.6759 | |
| SRP193095 | LASP1 | 3927 | RNAseq | -0.0223 | 0.9267 | |
| SRP219564 | LASP1 | 3927 | RNAseq | 0.3774 | 0.3088 | |
| TCGA | LASP1 | 3927 | RNAseq | -0.0783 | 0.0480 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LASP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LASP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LASP1 | 3927 | 7 | 1 | 22 | |
| GSE20123 | LASP1 | 3927 | 7 | 1 | 22 | |
| GSE43470 | LASP1 | 3927 | 1 | 1 | 41 | |
| GSE46452 | LASP1 | 3927 | 34 | 0 | 25 | |
| GSE47630 | LASP1 | 3927 | 8 | 1 | 31 | |
| GSE54993 | LASP1 | 3927 | 3 | 4 | 63 | |
| GSE54994 | LASP1 | 3927 | 8 | 5 | 40 | |
| GSE60625 | LASP1 | 3927 | 4 | 0 | 7 | |
| GSE74703 | LASP1 | 3927 | 1 | 0 | 35 | |
| GSE74704 | LASP1 | 3927 | 4 | 1 | 15 | |
| TCGA | LASP1 | 3927 | 19 | 8 | 69 |
Total number of gains: 96; Total number of losses: 22; Total Number of normals: 370.
Somatic mutations of LASP1:
Generating mutation plots.
Highly correlated genes for LASP1:
Showing top 20/1021 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LASP1 | WIPI1 | 0.763339 | 3 | 0 | 3 |
| LASP1 | CLPTM1L | 0.761082 | 4 | 0 | 4 |
| LASP1 | PPP1R9B | 0.735712 | 3 | 0 | 3 |
| LASP1 | PDIA5 | 0.728505 | 3 | 0 | 3 |
| LASP1 | SLC30A7 | 0.728312 | 4 | 0 | 3 |
| LASP1 | TMED9 | 0.725676 | 3 | 0 | 3 |
| LASP1 | CDCA2 | 0.722661 | 3 | 0 | 3 |
| LASP1 | SLC35B2 | 0.714969 | 3 | 0 | 3 |
| LASP1 | HAS3 | 0.713764 | 3 | 0 | 3 |
| LASP1 | B3GALT6 | 0.705405 | 4 | 0 | 4 |
| LASP1 | SPON2 | 0.702716 | 3 | 0 | 3 |
| LASP1 | ADAM10 | 0.700864 | 4 | 0 | 4 |
| LASP1 | XPR1 | 0.695288 | 5 | 0 | 5 |
| LASP1 | TXNDC9 | 0.695218 | 4 | 0 | 4 |
| LASP1 | PI4K2A | 0.695117 | 3 | 0 | 3 |
| LASP1 | ARHGEF18 | 0.693572 | 3 | 0 | 3 |
| LASP1 | RACGAP1 | 0.691103 | 5 | 0 | 5 |
| LASP1 | RSPRY1 | 0.688522 | 3 | 0 | 3 |
| LASP1 | FAM89A | 0.684365 | 3 | 0 | 3 |
| LASP1 | HOXC13 | 0.68358 | 3 | 0 | 3 |
For details and further investigation, click here
