| Full name: pleckstrin homology domain containing A4 | Alias Symbol: PEPP1 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 57664 | HGNC ID: HGNC:14339 | Ensembl Gene: ENSG00000105559 | OMIM ID: 607769 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHA4 | 57664 | 219011_at | 0.3071 | 0.6112 | |
| GSE20347 | PLEKHA4 | 57664 | 219011_at | 0.2816 | 0.0058 | |
| GSE23400 | PLEKHA4 | 57664 | 219011_at | -0.0436 | 0.4211 | |
| GSE26886 | PLEKHA4 | 57664 | 219011_at | 0.6226 | 0.0004 | |
| GSE29001 | PLEKHA4 | 57664 | 219011_at | 0.1047 | 0.6699 | |
| GSE38129 | PLEKHA4 | 57664 | 219011_at | 0.1139 | 0.4770 | |
| GSE45670 | PLEKHA4 | 57664 | 219011_at | 0.0161 | 0.9279 | |
| GSE53622 | PLEKHA4 | 57664 | 70719 | -0.3596 | 0.0147 | |
| GSE53624 | PLEKHA4 | 57664 | 70719 | 0.0987 | 0.4251 | |
| GSE63941 | PLEKHA4 | 57664 | 219011_at | -1.0903 | 0.0028 | |
| GSE77861 | PLEKHA4 | 57664 | 219011_at | -0.0212 | 0.9219 | |
| GSE97050 | PLEKHA4 | 57664 | A_24_P408047 | 0.1482 | 0.7423 | |
| SRP007169 | PLEKHA4 | 57664 | RNAseq | 1.6161 | 0.0467 | |
| SRP064894 | PLEKHA4 | 57664 | RNAseq | 1.3626 | 0.0001 | |
| SRP133303 | PLEKHA4 | 57664 | RNAseq | -0.1475 | 0.5989 | |
| SRP159526 | PLEKHA4 | 57664 | RNAseq | 0.8009 | 0.1277 | |
| SRP193095 | PLEKHA4 | 57664 | RNAseq | 0.8990 | 0.0001 | |
| SRP219564 | PLEKHA4 | 57664 | RNAseq | 0.1541 | 0.8449 | |
| TCGA | PLEKHA4 | 57664 | RNAseq | -0.1020 | 0.3557 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by PLEKHA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHA4 | 57664 | 4 | 4 | 22 | |
| GSE20123 | PLEKHA4 | 57664 | 4 | 3 | 23 | |
| GSE43470 | PLEKHA4 | 57664 | 4 | 10 | 29 | |
| GSE46452 | PLEKHA4 | 57664 | 45 | 1 | 13 | |
| GSE47630 | PLEKHA4 | 57664 | 9 | 6 | 25 | |
| GSE54993 | PLEKHA4 | 57664 | 17 | 4 | 49 | |
| GSE54994 | PLEKHA4 | 57664 | 4 | 14 | 35 | |
| GSE60625 | PLEKHA4 | 57664 | 9 | 0 | 2 | |
| GSE74703 | PLEKHA4 | 57664 | 4 | 7 | 25 | |
| GSE74704 | PLEKHA4 | 57664 | 4 | 1 | 15 | |
| TCGA | PLEKHA4 | 57664 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of PLEKHA4:
Generating mutation plots.
Highly correlated genes for PLEKHA4:
Showing top 20/793 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHA4 | ELFN1 | 0.866292 | 3 | 0 | 3 |
| PLEKHA4 | BCAS4 | 0.805702 | 4 | 0 | 4 |
| PLEKHA4 | C11orf96 | 0.803762 | 3 | 0 | 3 |
| PLEKHA4 | LINGO1 | 0.797648 | 3 | 0 | 3 |
| PLEKHA4 | STK32B | 0.791962 | 3 | 0 | 3 |
| PLEKHA4 | SLC39A3 | 0.778695 | 4 | 0 | 4 |
| PLEKHA4 | TRIM47 | 0.762827 | 4 | 0 | 4 |
| PLEKHA4 | RILP | 0.762612 | 3 | 0 | 3 |
| PLEKHA4 | UBASH3A | 0.752135 | 3 | 0 | 3 |
| PLEKHA4 | HKDC1 | 0.747484 | 3 | 0 | 3 |
| PLEKHA4 | MMP3 | 0.745506 | 3 | 0 | 3 |
| PLEKHA4 | GDF11 | 0.744635 | 4 | 0 | 4 |
| PLEKHA4 | MED12 | 0.743182 | 4 | 0 | 4 |
| PLEKHA4 | ALDH1L2 | 0.742798 | 3 | 0 | 3 |
| PLEKHA4 | GPR132 | 0.740681 | 3 | 0 | 3 |
| PLEKHA4 | KLRC3 | 0.737791 | 3 | 0 | 3 |
| PLEKHA4 | CPT1C | 0.737067 | 4 | 0 | 4 |
| PLEKHA4 | TEAD2 | 0.73381 | 4 | 0 | 4 |
| PLEKHA4 | FOXP4 | 0.730982 | 3 | 0 | 3 |
| PLEKHA4 | SNAPC4 | 0.723954 | 5 | 0 | 4 |
For details and further investigation, click here
