| Full name: choline O-acetyltransferase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q11.23 | ||
| Entrez ID: 1103 | HGNC ID: HGNC:1912 | Ensembl Gene: ENSG00000070748 | OMIM ID: 118490 |
| Drug and gene relationship at DGIdb | |||
Expression of CHAT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHAT | 1103 | 221197_s_at | 0.2429 | 0.3205 | |
| GSE20347 | CHAT | 1103 | 221197_s_at | 0.0255 | 0.8014 | |
| GSE23400 | CHAT | 1103 | 221197_s_at | -0.0511 | 0.1385 | |
| GSE26886 | CHAT | 1103 | 221197_s_at | -0.0201 | 0.8680 | |
| GSE29001 | CHAT | 1103 | 221197_s_at | -0.0725 | 0.6516 | |
| GSE38129 | CHAT | 1103 | 221197_s_at | -0.0286 | 0.7463 | |
| GSE45670 | CHAT | 1103 | 221197_s_at | 0.2105 | 0.0121 | |
| GSE53622 | CHAT | 1103 | 44786 | 0.0729 | 0.3621 | |
| GSE53624 | CHAT | 1103 | 12901 | 0.5672 | 0.0033 | |
| GSE63941 | CHAT | 1103 | 221197_s_at | 0.0664 | 0.6825 | |
| GSE77861 | CHAT | 1103 | 221197_s_at | -0.0219 | 0.8169 | |
| TCGA | CHAT | 1103 | RNAseq | -0.8684 | 0.5423 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHAT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHAT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHAT | 1103 | 2 | 5 | 23 | |
| GSE20123 | CHAT | 1103 | 2 | 5 | 23 | |
| GSE43470 | CHAT | 1103 | 2 | 6 | 35 | |
| GSE46452 | CHAT | 1103 | 0 | 13 | 46 | |
| GSE47630 | CHAT | 1103 | 4 | 12 | 24 | |
| GSE54993 | CHAT | 1103 | 9 | 0 | 61 | |
| GSE54994 | CHAT | 1103 | 2 | 10 | 41 | |
| GSE60625 | CHAT | 1103 | 0 | 0 | 11 | |
| GSE74703 | CHAT | 1103 | 2 | 3 | 31 | |
| GSE74704 | CHAT | 1103 | 1 | 4 | 15 | |
| TCGA | CHAT | 1103 | 12 | 22 | 62 |
Total number of gains: 36; Total number of losses: 80; Total Number of normals: 372.
Somatic mutations of CHAT:
Generating mutation plots.
Highly correlated genes for CHAT:
Showing top 20/695 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHAT | NEUROD2 | 0.753089 | 4 | 0 | 4 |
| CHAT | ATG10 | 0.746986 | 4 | 0 | 4 |
| CHAT | IFNA14 | 0.733888 | 4 | 0 | 4 |
| CHAT | BCAN | 0.733595 | 5 | 0 | 5 |
| CHAT | BRS3 | 0.732577 | 3 | 0 | 3 |
| CHAT | HAND1 | 0.727146 | 4 | 0 | 4 |
| CHAT | SYT13 | 0.727102 | 3 | 0 | 3 |
| CHAT | CPA2 | 0.725816 | 3 | 0 | 3 |
| CHAT | NTNG1 | 0.717216 | 4 | 0 | 4 |
| CHAT | C8A | 0.703306 | 4 | 0 | 4 |
| CHAT | CDON | 0.702424 | 4 | 0 | 4 |
| CHAT | CDH7 | 0.701588 | 3 | 0 | 3 |
| CHAT | MTAP | 0.70136 | 4 | 0 | 4 |
| CHAT | TSHR | 0.700849 | 4 | 0 | 4 |
| CHAT | TMPRSS5 | 0.697224 | 5 | 0 | 5 |
| CHAT | RHPN1-AS1 | 0.694162 | 5 | 0 | 5 |
| CHAT | PRSS50 | 0.69254 | 3 | 0 | 3 |
| CHAT | CLCNKB | 0.69011 | 3 | 0 | 3 |
| CHAT | ZMAT4 | 0.68894 | 3 | 0 | 3 |
| CHAT | PPP1R14D | 0.686966 | 4 | 0 | 3 |
For details and further investigation, click here
