| Full name: TNF superfamily member 11 | Alias Symbol: TRANCE|RANKL|OPGL|ODF|CD254 | ||
| Type: protein-coding gene | Cytoband: 13q14 | ||
| Entrez ID: 8600 | HGNC ID: HGNC:11926 | Ensembl Gene: ENSG00000120659 | OMIM ID: 602642 |
| Drug and gene relationship at DGIdb | |||
TNFSF11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04380 | Osteoclast differentiation | |
| hsa04917 | Prolactin signaling pathway |
Expression of TNFSF11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFSF11 | 8600 | 211153_s_at | 0.0119 | 0.9813 | |
| GSE20347 | TNFSF11 | 8600 | 211153_s_at | -0.0582 | 0.4636 | |
| GSE23400 | TNFSF11 | 8600 | 211153_s_at | -0.1260 | 0.0019 | |
| GSE26886 | TNFSF11 | 8600 | 211153_s_at | 0.1373 | 0.2829 | |
| GSE29001 | TNFSF11 | 8600 | 211153_s_at | -0.0881 | 0.5441 | |
| GSE38129 | TNFSF11 | 8600 | 211153_s_at | -0.0546 | 0.4595 | |
| GSE45670 | TNFSF11 | 8600 | 211153_s_at | 0.0618 | 0.5128 | |
| GSE53622 | TNFSF11 | 8600 | 15355 | 0.2622 | 0.0003 | |
| GSE53624 | TNFSF11 | 8600 | 15355 | 0.5243 | 0.0000 | |
| GSE63941 | TNFSF11 | 8600 | 211153_s_at | 0.2726 | 0.1178 | |
| GSE77861 | TNFSF11 | 8600 | 211153_s_at | 0.0067 | 0.9671 | |
| GSE97050 | TNFSF11 | 8600 | A_23_P99386 | 0.1499 | 0.5102 | |
| SRP133303 | TNFSF11 | 8600 | RNAseq | 1.2477 | 0.0005 | |
| TCGA | TNFSF11 | 8600 | RNAseq | 1.5312 | 0.0002 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TNFSF11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFSF11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFSF11 | 8600 | 0 | 13 | 17 | |
| GSE20123 | TNFSF11 | 8600 | 0 | 12 | 18 | |
| GSE43470 | TNFSF11 | 8600 | 3 | 13 | 27 | |
| GSE46452 | TNFSF11 | 8600 | 0 | 33 | 26 | |
| GSE47630 | TNFSF11 | 8600 | 2 | 27 | 11 | |
| GSE54993 | TNFSF11 | 8600 | 12 | 2 | 56 | |
| GSE54994 | TNFSF11 | 8600 | 1 | 16 | 36 | |
| GSE60625 | TNFSF11 | 8600 | 0 | 3 | 8 | |
| GSE74703 | TNFSF11 | 8600 | 3 | 10 | 23 | |
| GSE74704 | TNFSF11 | 8600 | 0 | 9 | 11 | |
| TCGA | TNFSF11 | 8600 | 8 | 40 | 48 |
Total number of gains: 29; Total number of losses: 178; Total Number of normals: 281.
Somatic mutations of TNFSF11:
Generating mutation plots.
Highly correlated genes for TNFSF11:
Showing top 20/925 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFSF11 | ALPL | 0.764129 | 3 | 0 | 3 |
| TNFSF11 | AQP10 | 0.757143 | 3 | 0 | 3 |
| TNFSF11 | KRTAP4-8 | 0.754979 | 3 | 0 | 3 |
| TNFSF11 | ABCB9 | 0.737136 | 3 | 0 | 3 |
| TNFSF11 | BMF | 0.729847 | 3 | 0 | 3 |
| TNFSF11 | ZGLP1 | 0.728315 | 3 | 0 | 3 |
| TNFSF11 | CARNS1 | 0.72568 | 3 | 0 | 3 |
| TNFSF11 | SLC22A12 | 0.724774 | 3 | 0 | 3 |
| TNFSF11 | FOLH1 | 0.723136 | 5 | 0 | 5 |
| TNFSF11 | SHANK1 | 0.722601 | 3 | 0 | 3 |
| TNFSF11 | PHF7 | 0.716881 | 5 | 0 | 5 |
| TNFSF11 | TEKT2 | 0.715126 | 4 | 0 | 3 |
| TNFSF11 | SEC14L4 | 0.711101 | 4 | 0 | 4 |
| TNFSF11 | C7orf61 | 0.710005 | 3 | 0 | 3 |
| TNFSF11 | ACSM5 | 0.705734 | 4 | 0 | 3 |
| TNFSF11 | TCTE3 | 0.705221 | 4 | 0 | 4 |
| TNFSF11 | TRIM43 | 0.703428 | 3 | 0 | 3 |
| TNFSF11 | FSTL4 | 0.699377 | 5 | 0 | 4 |
| TNFSF11 | AMBN | 0.699368 | 7 | 0 | 7 |
| TNFSF11 | UMOD | 0.699085 | 5 | 0 | 5 |
For details and further investigation, click here
