| Full name: protein tyrosine phosphatase non-receptor type 21 | Alias Symbol: PTPD1|PTPRL10 | ||
| Type: protein-coding gene | Cytoband: 14q31.3 | ||
| Entrez ID: 11099 | HGNC ID: HGNC:9651 | Ensembl Gene: ENSG00000070778 | OMIM ID: 603271 |
| Drug and gene relationship at DGIdb | |||
Expression of PTPN21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN21 | 11099 | 226380_at | -0.7055 | 0.2261 | |
| GSE20347 | PTPN21 | 11099 | 205438_at | -0.3233 | 0.0018 | |
| GSE23400 | PTPN21 | 11099 | 205438_at | -0.0831 | 0.1502 | |
| GSE26886 | PTPN21 | 11099 | 226380_at | -0.6702 | 0.0407 | |
| GSE29001 | PTPN21 | 11099 | 40524_at | -0.2737 | 0.2460 | |
| GSE38129 | PTPN21 | 11099 | 205438_at | -0.2843 | 0.0191 | |
| GSE45670 | PTPN21 | 11099 | 226380_at | -0.6401 | 0.0016 | |
| GSE63941 | PTPN21 | 11099 | 226380_at | -2.1868 | 0.0033 | |
| GSE77861 | PTPN21 | 11099 | 226380_at | -0.3305 | 0.5699 | |
| GSE97050 | PTPN21 | 11099 | A_33_P3235990 | -0.8878 | 0.0705 | |
| SRP007169 | PTPN21 | 11099 | RNAseq | -0.2247 | 0.6196 | |
| SRP008496 | PTPN21 | 11099 | RNAseq | -0.1150 | 0.7324 | |
| SRP064894 | PTPN21 | 11099 | RNAseq | -0.0976 | 0.6008 | |
| SRP133303 | PTPN21 | 11099 | RNAseq | -0.2301 | 0.3641 | |
| SRP159526 | PTPN21 | 11099 | RNAseq | -1.1312 | 0.0001 | |
| SRP193095 | PTPN21 | 11099 | RNAseq | -0.3560 | 0.0252 | |
| SRP219564 | PTPN21 | 11099 | RNAseq | -0.5439 | 0.0909 | |
| TCGA | PTPN21 | 11099 | RNAseq | -0.4751 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PTPN21 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PTPN21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN21 | 11099 | 7 | 4 | 19 | |
| GSE20123 | PTPN21 | 11099 | 7 | 4 | 19 | |
| GSE43470 | PTPN21 | 11099 | 7 | 3 | 33 | |
| GSE46452 | PTPN21 | 11099 | 16 | 3 | 40 | |
| GSE47630 | PTPN21 | 11099 | 11 | 8 | 21 | |
| GSE54993 | PTPN21 | 11099 | 3 | 8 | 59 | |
| GSE54994 | PTPN21 | 11099 | 19 | 4 | 30 | |
| GSE60625 | PTPN21 | 11099 | 0 | 2 | 9 | |
| GSE74703 | PTPN21 | 11099 | 6 | 3 | 27 | |
| GSE74704 | PTPN21 | 11099 | 4 | 4 | 12 | |
| TCGA | PTPN21 | 11099 | 30 | 21 | 45 |
Total number of gains: 110; Total number of losses: 64; Total Number of normals: 314.
Somatic mutations of PTPN21:
Generating mutation plots.
Highly correlated genes for PTPN21:
Showing top 20/697 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN21 | ADD1 | 0.776297 | 4 | 0 | 4 |
| PTPN21 | TOB2 | 0.761529 | 3 | 0 | 3 |
| PTPN21 | UHRF2 | 0.759048 | 3 | 0 | 3 |
| PTPN21 | RGMB | 0.75323 | 3 | 0 | 3 |
| PTPN21 | DNALI1 | 0.753146 | 3 | 0 | 3 |
| PTPN21 | STX2 | 0.750823 | 3 | 0 | 3 |
| PTPN21 | CEP112 | 0.744259 | 4 | 0 | 4 |
| PTPN21 | ROCK1 | 0.739265 | 3 | 0 | 3 |
| PTPN21 | NFIA | 0.738809 | 4 | 0 | 4 |
| PTPN21 | ZNF407 | 0.735872 | 3 | 0 | 3 |
| PTPN21 | S1PR3 | 0.731763 | 3 | 0 | 3 |
| PTPN21 | SORCS1 | 0.731317 | 3 | 0 | 3 |
| PTPN21 | ANKRD13A | 0.730806 | 3 | 0 | 3 |
| PTPN21 | RYR3 | 0.729194 | 3 | 0 | 3 |
| PTPN21 | SLC25A27 | 0.72651 | 3 | 0 | 3 |
| PTPN21 | AUH | 0.725051 | 3 | 0 | 3 |
| PTPN21 | KLHL21 | 0.72486 | 3 | 0 | 3 |
| PTPN21 | MEIS2 | 0.720395 | 3 | 0 | 3 |
| PTPN21 | MCAM | 0.720311 | 3 | 0 | 3 |
| PTPN21 | SYNC | 0.718365 | 5 | 0 | 5 |
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