| Full name: HEXIM P-TEFb complex subunit 1 | Alias Symbol: CLP-1|HIS1|MAQ1|EDG1 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 10614 | HGNC ID: HGNC:24953 | Ensembl Gene: ENSG00000186834 | OMIM ID: 607328 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HEXIM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HEXIM1 | 10614 | 202814_s_at | -0.3638 | 0.4626 | |
| GSE20347 | HEXIM1 | 10614 | 202814_s_at | -0.3124 | 0.0122 | |
| GSE23400 | HEXIM1 | 10614 | 202815_s_at | -0.1437 | 0.0014 | |
| GSE26886 | HEXIM1 | 10614 | 202814_s_at | -0.8510 | 0.0001 | |
| GSE29001 | HEXIM1 | 10614 | 202814_s_at | -0.1447 | 0.6364 | |
| GSE38129 | HEXIM1 | 10614 | 202814_s_at | -0.2284 | 0.0368 | |
| GSE45670 | HEXIM1 | 10614 | 202814_s_at | 0.1428 | 0.3241 | |
| GSE53622 | HEXIM1 | 10614 | 21417 | -0.4619 | 0.0000 | |
| GSE53624 | HEXIM1 | 10614 | 21417 | -0.3469 | 0.0000 | |
| GSE63941 | HEXIM1 | 10614 | 202814_s_at | 0.4838 | 0.3529 | |
| GSE77861 | HEXIM1 | 10614 | 202814_s_at | -0.1414 | 0.6082 | |
| GSE97050 | HEXIM1 | 10614 | A_24_P356601 | -0.8854 | 0.0706 | |
| SRP007169 | HEXIM1 | 10614 | RNAseq | -0.6576 | 0.1401 | |
| SRP008496 | HEXIM1 | 10614 | RNAseq | -0.7317 | 0.0115 | |
| SRP064894 | HEXIM1 | 10614 | RNAseq | -0.4102 | 0.0011 | |
| SRP133303 | HEXIM1 | 10614 | RNAseq | -0.4505 | 0.0004 | |
| SRP159526 | HEXIM1 | 10614 | RNAseq | -0.4635 | 0.0967 | |
| SRP193095 | HEXIM1 | 10614 | RNAseq | -0.5088 | 0.0000 | |
| SRP219564 | HEXIM1 | 10614 | RNAseq | -0.1827 | 0.5032 | |
| TCGA | HEXIM1 | 10614 | RNAseq | -0.1221 | 0.0124 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HEXIM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HEXIM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HEXIM1 | 10614 | 6 | 2 | 22 | |
| GSE20123 | HEXIM1 | 10614 | 6 | 2 | 22 | |
| GSE43470 | HEXIM1 | 10614 | 3 | 2 | 38 | |
| GSE46452 | HEXIM1 | 10614 | 32 | 0 | 27 | |
| GSE47630 | HEXIM1 | 10614 | 9 | 0 | 31 | |
| GSE54993 | HEXIM1 | 10614 | 3 | 4 | 63 | |
| GSE54994 | HEXIM1 | 10614 | 9 | 5 | 39 | |
| GSE60625 | HEXIM1 | 10614 | 4 | 0 | 7 | |
| GSE74703 | HEXIM1 | 10614 | 2 | 1 | 33 | |
| GSE74704 | HEXIM1 | 10614 | 4 | 1 | 15 | |
| TCGA | HEXIM1 | 10614 | 26 | 7 | 63 |
Total number of gains: 104; Total number of losses: 24; Total Number of normals: 360.
Somatic mutations of HEXIM1:
Generating mutation plots.
Highly correlated genes for HEXIM1:
Showing top 20/624 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HEXIM1 | SLC35A1 | 0.804799 | 3 | 0 | 3 |
| HEXIM1 | TOB2 | 0.730765 | 3 | 0 | 3 |
| HEXIM1 | SLMAP | 0.724439 | 3 | 0 | 3 |
| HEXIM1 | KLHDC8B | 0.712274 | 4 | 0 | 4 |
| HEXIM1 | CCNYL1 | 0.708781 | 3 | 0 | 3 |
| HEXIM1 | TBC1D23 | 0.704619 | 3 | 0 | 3 |
| HEXIM1 | B3GAT2 | 0.700052 | 3 | 0 | 3 |
| HEXIM1 | GPR108 | 0.697448 | 3 | 0 | 3 |
| HEXIM1 | TEAD1 | 0.696694 | 3 | 0 | 3 |
| HEXIM1 | THUMPD3 | 0.694576 | 3 | 0 | 3 |
| HEXIM1 | GOT1 | 0.690835 | 3 | 0 | 3 |
| HEXIM1 | SLC12A6 | 0.690808 | 4 | 0 | 4 |
| HEXIM1 | ZFYVE1 | 0.69069 | 4 | 0 | 3 |
| HEXIM1 | ELMOD2 | 0.686589 | 3 | 0 | 3 |
| HEXIM1 | ANKRD13A | 0.685121 | 4 | 0 | 3 |
| HEXIM1 | ATP6V0E1 | 0.684702 | 3 | 0 | 3 |
| HEXIM1 | MRPS7 | 0.684147 | 3 | 0 | 3 |
| HEXIM1 | CTTNBP2NL | 0.683874 | 4 | 0 | 4 |
| HEXIM1 | UBQLN1 | 0.683852 | 3 | 0 | 3 |
| HEXIM1 | MBOAT2 | 0.68248 | 3 | 0 | 3 |
For details and further investigation, click here
