| Full name: VPS41 subunit of HOPS complex | Alias Symbol: HVSP41 | ||
| Type: protein-coding gene | Cytoband: 7p14.1 | ||
| Entrez ID: 27072 | HGNC ID: HGNC:12713 | Ensembl Gene: ENSG00000006715 | OMIM ID: 605485 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS41:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS41 | 27072 | 210849_s_at | 0.0642 | 0.9006 | |
| GSE20347 | VPS41 | 27072 | 210849_s_at | 0.1784 | 0.1870 | |
| GSE23400 | VPS41 | 27072 | 210849_s_at | 0.0783 | 0.1739 | |
| GSE26886 | VPS41 | 27072 | 210849_s_at | -0.0849 | 0.6977 | |
| GSE29001 | VPS41 | 27072 | 210849_s_at | 0.1285 | 0.5980 | |
| GSE38129 | VPS41 | 27072 | 210849_s_at | 0.2923 | 0.0076 | |
| GSE45670 | VPS41 | 27072 | 210849_s_at | -0.1165 | 0.3368 | |
| GSE53622 | VPS41 | 27072 | 99468 | 0.0477 | 0.5446 | |
| GSE53624 | VPS41 | 27072 | 99468 | 0.1236 | 0.3608 | |
| GSE63941 | VPS41 | 27072 | 210849_s_at | -0.1011 | 0.8298 | |
| GSE77861 | VPS41 | 27072 | 210849_s_at | -0.1673 | 0.4379 | |
| GSE97050 | VPS41 | 27072 | A_23_P215318 | 0.0151 | 0.9728 | |
| SRP007169 | VPS41 | 27072 | RNAseq | -0.5953 | 0.0785 | |
| SRP008496 | VPS41 | 27072 | RNAseq | -0.1989 | 0.4029 | |
| SRP064894 | VPS41 | 27072 | RNAseq | -0.0574 | 0.6762 | |
| SRP133303 | VPS41 | 27072 | RNAseq | 0.3259 | 0.0057 | |
| SRP159526 | VPS41 | 27072 | RNAseq | -0.0411 | 0.8319 | |
| SRP193095 | VPS41 | 27072 | RNAseq | -0.0566 | 0.5665 | |
| SRP219564 | VPS41 | 27072 | RNAseq | -0.1665 | 0.5463 | |
| TCGA | VPS41 | 27072 | RNAseq | -0.0840 | 0.0858 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS41 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS41:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS41 | 27072 | 15 | 0 | 15 | |
| GSE20123 | VPS41 | 27072 | 14 | 0 | 16 | |
| GSE43470 | VPS41 | 27072 | 4 | 0 | 39 | |
| GSE46452 | VPS41 | 27072 | 11 | 1 | 47 | |
| GSE47630 | VPS41 | 27072 | 8 | 1 | 31 | |
| GSE54993 | VPS41 | 27072 | 0 | 7 | 63 | |
| GSE54994 | VPS41 | 27072 | 18 | 3 | 32 | |
| GSE60625 | VPS41 | 27072 | 0 | 0 | 11 | |
| GSE74703 | VPS41 | 27072 | 4 | 0 | 32 | |
| GSE74704 | VPS41 | 27072 | 8 | 0 | 12 | |
| TCGA | VPS41 | 27072 | 53 | 6 | 37 |
Total number of gains: 135; Total number of losses: 18; Total Number of normals: 335.
Somatic mutations of VPS41:
Generating mutation plots.
Highly correlated genes for VPS41:
Showing top 20/169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS41 | MRPS14 | 0.78463 | 3 | 0 | 3 |
| VPS41 | CRCP | 0.779565 | 3 | 0 | 3 |
| VPS41 | ZNF626 | 0.77411 | 3 | 0 | 3 |
| VPS41 | TOP3A | 0.773832 | 3 | 0 | 3 |
| VPS41 | CMC1 | 0.766979 | 3 | 0 | 3 |
| VPS41 | UBR2 | 0.758771 | 3 | 0 | 3 |
| VPS41 | JAG1 | 0.74739 | 3 | 0 | 3 |
| VPS41 | CHCHD4 | 0.746731 | 3 | 0 | 3 |
| VPS41 | DPH5 | 0.728878 | 3 | 0 | 3 |
| VPS41 | ANKRD28 | 0.725321 | 3 | 0 | 3 |
| VPS41 | BTN2A1 | 0.723409 | 3 | 0 | 3 |
| VPS41 | MGMT | 0.716219 | 3 | 0 | 3 |
| VPS41 | MCM8 | 0.71275 | 3 | 0 | 3 |
| VPS41 | MED4 | 0.706991 | 4 | 0 | 4 |
| VPS41 | TSEN34 | 0.705158 | 3 | 0 | 3 |
| VPS41 | POLR2G | 0.704465 | 4 | 0 | 4 |
| VPS41 | LEMD2 | 0.698996 | 3 | 0 | 3 |
| VPS41 | PHB | 0.6958 | 3 | 0 | 3 |
| VPS41 | LIN52 | 0.694266 | 4 | 0 | 4 |
| VPS41 | ZNF546 | 0.693756 | 3 | 0 | 3 |
For details and further investigation, click here
