| Full name: intracisternal A particle-promoted polypeptide | Alias Symbol: KLHL27 | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 3652 | HGNC ID: HGNC:6108 | Ensembl Gene: ENSG00000197429 | OMIM ID: 147485 |
| Drug and gene relationship at DGIdb | |||
Expression of IPP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IPP | 3652 | 219843_at | -0.2377 | 0.5425 | |
| GSE20347 | IPP | 3652 | 219843_at | -0.3153 | 0.0172 | |
| GSE23400 | IPP | 3652 | 219843_at | -0.0348 | 0.6525 | |
| GSE26886 | IPP | 3652 | 241434_at | 0.4128 | 0.0655 | |
| GSE29001 | IPP | 3652 | 219843_at | 0.0453 | 0.9122 | |
| GSE38129 | IPP | 3652 | 219843_at | -0.2222 | 0.1449 | |
| GSE45670 | IPP | 3652 | 219843_at | -0.1858 | 0.5065 | |
| GSE53622 | IPP | 3652 | 145939 | -0.1756 | 0.0016 | |
| GSE53624 | IPP | 3652 | 145939 | -0.0727 | 0.2345 | |
| GSE63941 | IPP | 3652 | 1554740_a_at | 0.8611 | 0.0618 | |
| GSE77861 | IPP | 3652 | 219843_at | 0.2723 | 0.4455 | |
| GSE97050 | IPP | 3652 | A_23_P9662 | -0.2109 | 0.4738 | |
| SRP007169 | IPP | 3652 | RNAseq | -1.6832 | 0.0001 | |
| SRP008496 | IPP | 3652 | RNAseq | -1.0265 | 0.0013 | |
| SRP064894 | IPP | 3652 | RNAseq | -0.4947 | 0.0069 | |
| SRP133303 | IPP | 3652 | RNAseq | -0.1625 | 0.2279 | |
| SRP159526 | IPP | 3652 | RNAseq | -0.2246 | 0.3726 | |
| SRP193095 | IPP | 3652 | RNAseq | -0.1670 | 0.0874 | |
| SRP219564 | IPP | 3652 | RNAseq | 0.0381 | 0.9306 | |
| TCGA | IPP | 3652 | RNAseq | -0.2028 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by IPP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IPP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IPP | 3652 | 4 | 3 | 23 | |
| GSE20123 | IPP | 3652 | 4 | 2 | 24 | |
| GSE43470 | IPP | 3652 | 6 | 2 | 35 | |
| GSE46452 | IPP | 3652 | 2 | 1 | 56 | |
| GSE47630 | IPP | 3652 | 8 | 4 | 28 | |
| GSE54993 | IPP | 3652 | 0 | 1 | 69 | |
| GSE54994 | IPP | 3652 | 11 | 2 | 40 | |
| GSE60625 | IPP | 3652 | 0 | 0 | 11 | |
| GSE74703 | IPP | 3652 | 5 | 1 | 30 | |
| GSE74704 | IPP | 3652 | 2 | 0 | 18 | |
| TCGA | IPP | 3652 | 11 | 16 | 69 |
Total number of gains: 53; Total number of losses: 32; Total Number of normals: 403.
Somatic mutations of IPP:
Generating mutation plots.
Highly correlated genes for IPP:
Showing top 20/125 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IPP | GDPD1 | 0.761191 | 4 | 0 | 3 |
| IPP | MYO3B | 0.750512 | 3 | 0 | 3 |
| IPP | FAF2 | 0.743398 | 3 | 0 | 3 |
| IPP | LUC7L2 | 0.741425 | 3 | 0 | 3 |
| IPP | PPP1R15B | 0.709852 | 3 | 0 | 3 |
| IPP | RSRC2 | 0.709748 | 3 | 0 | 3 |
| IPP | TOP3A | 0.697042 | 3 | 0 | 3 |
| IPP | RTN4IP1 | 0.694544 | 3 | 0 | 3 |
| IPP | THAP5 | 0.690246 | 3 | 0 | 3 |
| IPP | FCHSD2 | 0.686949 | 3 | 0 | 3 |
| IPP | WHAMM | 0.681282 | 5 | 0 | 4 |
| IPP | TNRC6A | 0.679773 | 3 | 0 | 3 |
| IPP | DPY19L2 | 0.677749 | 3 | 0 | 3 |
| IPP | ZNF514 | 0.675638 | 3 | 0 | 3 |
| IPP | GPR19 | 0.675612 | 3 | 0 | 3 |
| IPP | ZNF823 | 0.669796 | 3 | 0 | 3 |
| IPP | C7orf50 | 0.668426 | 3 | 0 | 3 |
| IPP | ITGB8 | 0.667611 | 3 | 0 | 3 |
| IPP | DCLRE1C | 0.661808 | 4 | 0 | 3 |
| IPP | LOXL4 | 0.659634 | 3 | 0 | 3 |
For details and further investigation, click here
