| Full name: phenylalanyl-tRNA synthetase 2, mitochondrial | Alias Symbol: dJ236A3.1|mtPheRS | ||
| Type: protein-coding gene | Cytoband: 6p25.1 | ||
| Entrez ID: 10667 | HGNC ID: HGNC:21062 | Ensembl Gene: ENSG00000145982 | OMIM ID: 611592 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FARS2 | 10667 | 204283_at | 0.3102 | 0.4215 | |
| GSE20347 | FARS2 | 10667 | 204282_s_at | 0.0363 | 0.7560 | |
| GSE23400 | FARS2 | 10667 | 204282_s_at | -0.0375 | 0.4434 | |
| GSE26886 | FARS2 | 10667 | 204282_s_at | 0.4976 | 0.0036 | |
| GSE29001 | FARS2 | 10667 | 204282_s_at | 0.2048 | 0.3865 | |
| GSE38129 | FARS2 | 10667 | 204282_s_at | -0.0306 | 0.7416 | |
| GSE45670 | FARS2 | 10667 | 204283_at | 0.0500 | 0.8518 | |
| GSE53622 | FARS2 | 10667 | 39331 | 0.1202 | 0.1149 | |
| GSE53624 | FARS2 | 10667 | 39331 | 0.1452 | 0.1225 | |
| GSE63941 | FARS2 | 10667 | 204283_at | 0.2984 | 0.3768 | |
| GSE77861 | FARS2 | 10667 | 204282_s_at | 0.0128 | 0.9503 | |
| GSE97050 | FARS2 | 10667 | A_23_P33720 | 0.0528 | 0.7908 | |
| SRP007169 | FARS2 | 10667 | RNAseq | -0.1220 | 0.7817 | |
| SRP008496 | FARS2 | 10667 | RNAseq | -0.0311 | 0.9036 | |
| SRP064894 | FARS2 | 10667 | RNAseq | 0.3707 | 0.1303 | |
| SRP133303 | FARS2 | 10667 | RNAseq | -0.0249 | 0.8800 | |
| SRP159526 | FARS2 | 10667 | RNAseq | 0.3296 | 0.2000 | |
| SRP193095 | FARS2 | 10667 | RNAseq | -0.0537 | 0.6061 | |
| SRP219564 | FARS2 | 10667 | RNAseq | -0.0351 | 0.9212 | |
| TCGA | FARS2 | 10667 | RNAseq | -0.0618 | 0.3421 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FARS2 | 10667 | 3 | 6 | 21 | |
| GSE20123 | FARS2 | 10667 | 3 | 6 | 21 | |
| GSE43470 | FARS2 | 10667 | 8 | 2 | 33 | |
| GSE46452 | FARS2 | 10667 | 1 | 10 | 48 | |
| GSE47630 | FARS2 | 10667 | 7 | 8 | 25 | |
| GSE54993 | FARS2 | 10667 | 1 | 1 | 68 | |
| GSE54994 | FARS2 | 10667 | 10 | 3 | 40 | |
| GSE60625 | FARS2 | 10667 | 0 | 1 | 10 | |
| GSE74703 | FARS2 | 10667 | 7 | 2 | 27 | |
| GSE74704 | FARS2 | 10667 | 2 | 2 | 16 | |
| TCGA | FARS2 | 10667 | 13 | 35 | 48 |
Total number of gains: 55; Total number of losses: 76; Total Number of normals: 357.
Somatic mutations of FARS2:
Generating mutation plots.
Highly correlated genes for FARS2:
Showing top 20/437 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FARS2 | IFT52 | 0.825116 | 3 | 0 | 3 |
| FARS2 | PIP4K2C | 0.814045 | 3 | 0 | 3 |
| FARS2 | COMMD2 | 0.81227 | 3 | 0 | 3 |
| FARS2 | CPT1C | 0.80226 | 3 | 0 | 3 |
| FARS2 | LRRC47 | 0.771345 | 3 | 0 | 3 |
| FARS2 | RNPS1 | 0.770953 | 3 | 0 | 3 |
| FARS2 | SLC37A3 | 0.770199 | 3 | 0 | 3 |
| FARS2 | CCT2 | 0.767844 | 3 | 0 | 3 |
| FARS2 | ICAM5 | 0.767232 | 3 | 0 | 3 |
| FARS2 | TRAF7 | 0.766699 | 3 | 0 | 3 |
| FARS2 | GAR1 | 0.766425 | 3 | 0 | 3 |
| FARS2 | TRUB1 | 0.766213 | 3 | 0 | 3 |
| FARS2 | GLB1L | 0.758251 | 3 | 0 | 3 |
| FARS2 | POLR2A | 0.756442 | 3 | 0 | 3 |
| FARS2 | MMP15 | 0.753152 | 4 | 0 | 4 |
| FARS2 | ATIC | 0.747777 | 3 | 0 | 3 |
| FARS2 | DDX54 | 0.745478 | 4 | 0 | 3 |
| FARS2 | KTN1 | 0.745408 | 3 | 0 | 3 |
| FARS2 | CTU2 | 0.743024 | 3 | 0 | 3 |
| FARS2 | CWF19L1 | 0.742708 | 3 | 0 | 3 |
For details and further investigation, click here
